UniProtKB - Q9X1B7 (CDSA_THEMA)
Protein
Phosphatidate cytidylyltransferase
Gene
cdsA
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Functioni
Catalytic activityi
- EC:2.7.7.41
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- no protein annotated in this organism
- no protein annotated in this organism
- Phosphatidate cytidylyltransferase (Tmari_1404), Phosphatidate cytidylyltransferase (cdsA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- phosphatidate cytidylyltransferase activity Source: GO_Central
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidate cytidylyltransferase (EC:2.7.7.41)Alternative name(s): CDP-DAG synthase CDP-DG synthase CDP-diacylglycerol synthase Short name: CDS CDP-diglyceride pyrophosphorylase CDP-diglyceride synthase CTP:phosphatidate cytidylyltransferase |
Gene namesi | Name:cdsA Ordered Locus Names:TM_1397 |
Organismi | Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) |
Taxonomic identifieri | 243274 [NCBI] |
Taxonomic lineagei | Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 55 – 75 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 104 – 124 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 170 – 190 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 193 – 213 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 248 – 268 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090758 | 1 – 270 | Phosphatidate cytidylyltransferaseAdd BLAST | 270 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9X1B7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the CDS family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0575, Bacteria |
InParanoidi | Q9X1B7 |
OMAi | GCIFLTM |
OrthoDBi | 1533756at2 |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9X1B7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDLKTRVIT ASVVAPFVVL CFVSYESLIG LVSAILILAG YELITLEMKE
60 70 80 90 100
RDARFFYVIL LALYPVLYGL VFEEPTQPLS ILFITGVVFS LITDKDPSQV
110 120 130 140 150
FKTVAAFSIA LIYVTFFLSF FLPIYRDFGA ANALLVLTST WVFDSFAYFT
160 170 180 190 200
GLKFGRTRIS PRYSPRKSLE GVIGGFLGVV IYTFLYRLVV NDLLSVNVIS
210 220 230 240 250
FRTFLPFAAT VAIMDTFGDI FESALKRHYG VKDSGKTLPG HGGMLDRIDG
260 270
LLFVAPVSYI VFKILEGVVR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000512 Genomic DNA Translation: AAD36468.1 |
PIRi | F72259 |
RefSeqi | NP_229198.1, NC_000853.1 WP_004081613.1, NZ_CP011107.1 |
Genome annotation databases
EnsemblBacteriai | AAD36468; AAD36468; TM_1397 |
KEGGi | tma:TM1397 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000512 Genomic DNA Translation: AAD36468.1 |
PIRi | F72259 |
RefSeqi | NP_229198.1, NC_000853.1 WP_004081613.1, NZ_CP011107.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4Q2E | X-ray | 3.40 | A/B | 1-270 | [»] | |
4Q2G | X-ray | 3.40 | A/B | 1-270 | [»] | |
SMRi | Q9X1B7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 243274.THEMA_07330 |
Genome annotation databases
EnsemblBacteriai | AAD36468; AAD36468; TM_1397 |
KEGGi | tma:TM1397 |
Phylogenomic databases
eggNOGi | COG0575, Bacteria |
InParanoidi | Q9X1B7 |
OMAi | GCIFLTM |
OrthoDBi | 1533756at2 |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDSA_THEMA | |
Accessioni | Q9X1B7Primary (citable) accession number: Q9X1B7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families