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UniProtKB - Q9X105 (MUTS2_THEMA)

Entry version 137 (02 Dec 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Endonuclease MutS2

Gene

mutS2

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity (Probable). Has ATPase activity. Binds to DNA.UniRule annotationCurated1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Nuclease activity is stimulated by interaction with MutL and inhibited in the presence of non-hydrolytic ATP (ADPnP). ATPase activity is stimulated by DNA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi321 – 328ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endonuclease MutS2UniRule annotation (EC:3.1.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mutS2UniRule annotation
Synonyms:mutSB
Ordered Locus Names:TM_1278
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243274 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008183 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001152381 – 757Endonuclease MutS2Add BLAST757

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with MutL.

UniRule annotation1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		243274.THEMA_07945

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9X105

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini681 – 756SmrUniRule annotationAdd BLAST76

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains an N-terminal DNA-binding domain, followed by a dimerization domain and a C-terminal domain, called the small MutS-related (Smr) domain, which is absent from MutS and contains the endonuclease activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1193, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9X105

Identification of Orthologs from Complete Genome Data

More...OMAi		IHAIIND

Database of Orthologous Groups

More...OrthoDBi		256392at2

Family and domain databases

Conserved Domains Database

More...CDDi		cd03280, ABC_MutS2, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00092, MutS2, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000432, DNA_mismatch_repair_MutS_C
IPR007696, DNA_mismatch_repair_MutS_core
IPR036187, DNA_mismatch_repair_MutS_sf
IPR005747, MutS2
IPR027417, P-loop_NTPase
IPR002625, Smr_dom
IPR036063, Smr_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11361:SF14, PTHR11361:SF14, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00488, MutS_V, 1 hit
PF01713, Smr, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005814, MutS_YshD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit
SM00463, SMR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF160443, SSF160443, 1 hit
SSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01069, mutS2, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit
PS50828, SMR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9X105-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYLESLDFP KVVEIVKKYA LSDLGRKHLD TLKPTVNPWD ELELVEELLN 
        60         70         80         90        100
YFNRWGEPPI KGLNDISQEV EKVKSGSPLE PWELLRVSVF LEGCDILKKE 
       110        120        130        140        150
FEKREYSRLK ETFSRLSSFR EFVEEVNRCI EQDGEISDRA SPRLREIRTE 
       160        170        180        190        200
KKRLSSEIKR KADDFVRTHS QILQEQMYVY RDGRYLFPVK ASMKNAVRGI 
       210        220        230        240        250
VHHLSSSGAT VFLEPDEFVE LNNRVRLLEE EERLEISRIL RQLTNILLSR 
       260        270        280        290        300
LNDLERNVEL IARFDSLYAR VKFAREFNGT VVKPSSRIRL VNARHPLIPK 
       310        320        330        340        350
ERVVPINLEL PPNKRGFIIT GPNMGGKTVT VKTVGLFTAL MMSGFPLPCD 
       360        370        380        390        400
EGTELKVFPK IMADIGEEQS IEQSLSTFSS HMKKIVEIVK NADSDSLVIL 
       410        420        430        440        450
DELGSGTDPV EGAALAIAII EDLLEKGATI FVTTHLTPVK VFAMNHPLLL 
       460        470        480        490        500
NASMEFDPET LSPTYRVLVG VPGGSHAFQI AEKLGLDKRI IENARSRLSR 
       510        520        530        540        550
EEMELEGLIR SLHEKISLLE EEKRKLQKER EEYMKLREKY EEDYKKLRRM 
       560        570        580        590        600
KIEEFDKELR ELNDYIRKVK KELDQAIHVA KTGSVDEMRE AVKTIEKEKK 
       610        620        630        640        650
DLEQKRIEEA TEEEIKPGDH VKMEGGTSVG KVVEVKSGTA LVDFGFLRLK 
       660        670        680        690        700
VPVSKLRKTK KEEKKETSTF SYKPSSFRTE IDIRGMTVEE AEPVVKKFID 
       710        720        730        740        750
DLMMNGISKG YIIHGKGTGK LASGVWEILR KDKRVVSFRF GTPSEGGTGV 

TVVEVKV
Length:757
Mass (Da):86,626
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i818F8C4F5C20426B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD36353.1

Protein sequence database of the Protein Information Resource

More...PIRi		B72273

NCBI Reference Sequences

More...RefSeqi		NP_229083.1, NC_000853.1
WP_004079958.1, NZ_CP011107.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAD36353; AAD36353; TM_1278

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		tma:TM1278

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD36353.1
PIRiB72273
RefSeqiNP_229083.1, NC_000853.1
WP_004079958.1, NZ_CP011107.1

3D structure databases

SMRiQ9X105
ModBaseiSearch...

Protein-protein interaction databases

STRINGi243274.THEMA_07945

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		898205

Genome annotation databases

EnsemblBacteriaiAAD36353; AAD36353; TM_1278
KEGGitma:TM1278

Phylogenomic databases

eggNOGiCOG1193, Bacteria
InParanoidiQ9X105
OMAiIHAIIND
OrthoDBi256392at2

Family and domain databases

CDDicd03280, ABC_MutS2, 1 hit
HAMAPiMF_00092, MutS2, 1 hit
InterProiView protein in InterPro
IPR000432, DNA_mismatch_repair_MutS_C
IPR007696, DNA_mismatch_repair_MutS_core
IPR036187, DNA_mismatch_repair_MutS_sf
IPR005747, MutS2
IPR027417, P-loop_NTPase
IPR002625, Smr_dom
IPR036063, Smr_dom_sf
PANTHERiPTHR11361:SF14, PTHR11361:SF14, 1 hit
PfamiView protein in Pfam
PF00488, MutS_V, 1 hit
PF01713, Smr, 1 hit
PIRSFiPIRSF005814, MutS_YshD, 1 hit
SMARTiView protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit
SM00463, SMR, 1 hit
SUPFAMiSSF160443, SSF160443, 1 hit
SSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR01069, mutS2, 1 hit
PROSITEiView protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit
PS50828, SMR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUTS2_THEMA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9X105
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: December 2, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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