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Protein

Aspartate aminotransferase

Gene

aspC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37Aspartate; via amide nitrogenBy similarity1
Binding sitei123AspartateBy similarity1
Binding sitei173AspartateBy similarity1
Binding sitei353AspartateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aspC
Ordered Locus Names:TM_1255
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238571 – 377Aspartate aminotransferaseAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234N6-(pyridoxal phosphate)lysine1

Proteomic databases

PRIDEiQ9X0Y2

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi243274.TM1255

Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9X0Y2
SMRiQ9X0Y2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9X0Y2

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM Bacteria
COG0436 LUCA
InParanoidiQ9X0Y2
KOiK00812
OMAiFYLYADV

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9X0Y2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSRRISEIP ISKTMELDAK AKALIKKGED VINLTAGEPD FPTPEPVVEE
60 70 80 90 100
AVRFLQKGEV KYTDPRGIYE LREGIAKRIG ERYKKDISPD QVVVTNGAKQ
110 120 130 140 150
ALFNAFMALL DPGDEVIVFS PVWVSYIPQI ILAGGTVNVV ETFMSKNFQP
160 170 180 190 200
SLEEVEGLLV GKTKAVLINS PNNPTGVVYR REFLEGLVRL AKKRNFYIIS
210 220 230 240 250
DEVYDSLVYT DEFTSILDVS EGFDRIVYIN GFSKSHSMTG WRVGYLISSE
260 270 280 290 300
KVATAVSKIQ SHTTSCINTV AQYAALKALE VDNSYMVQTF KERKNFVVER
310 320 330 340 350
LKKMGVKFVE PEGAFYLFFK VRGDDVKFCE RLLEEKKVAL VPGSAFLKPG
360 370
FVRLSFATSI ERLTEALDRI EDFLNSR
Length:377
Mass (Da):42,421
Last modified:November 1, 1999 - v1
Checksum:i4EB507704C45E221
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD36330.1
PIRiB72275
RefSeqiNP_229060.1, NC_000853.1
WP_004080007.1, NZ_CP011107.1

Genome annotation databases

EnsemblBacteriaiAAD36330; AAD36330; TM_1255
GeneIDi898228
KEGGitma:TM1255

Similar proteinsi

Entry informationi

Entry nameiAAT_THEMA
AccessioniPrimary (citable) accession number: Q9X0Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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