UniProtKB - Q9X0L4 (PTAS_THEMA)
Protein
Phosphate acetyltransferase
Gene
pta
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Functioni
In addition to acetyl-CoA (100%), the enzyme accepts propionyl-CoA (60%) and butyryl-CoA (30%).
Catalytic activityi
- EC:2.3.1.8
Temperature dependencei
Optimum temperature is 90 degrees Celsius.
: acetyl-CoA biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- Acetate kinase (ackA), Acetate kinase (ackA)
- Phosphate acetyltransferase (pta)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.
GO - Molecular functioni
- phosphate acetyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER-427 |
UniPathwayi | UPA00340;UER00459 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pta Ordered Locus Names:TM_1130 |
Organismi | Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) |
Taxonomic identifieri | 243274 [NCBI] |
Taxonomic lineagei | Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000179149 | 1 – 294 | Phosphate acetyltransferaseAdd BLAST | 294 |
Interactioni
Subunit structurei
Homotetramer.
Protein-protein interaction databases
DIPi | DIP-2900N |
STRINGi | 243274.THEMA_08695 |
Family & Domainsi
Sequence similaritiesi
Belongs to the phosphate acetyltransferase and butyryltransferase family.Curated
Phylogenomic databases
eggNOGi | COG0280, Bacteria |
InParanoidi | Q9X0L4 |
OMAi | CIVDGPF |
OrthoDBi | 1301815at2 |
Family and domain databases
InterProi | View protein in InterPro IPR012147, P_Ac_Bu_trans IPR002505, PTA_PTB |
Pfami | View protein in Pfam PF01515, PTA_PTB, 1 hit |
PIRSFi | PIRSF000428, P_Ac_trans, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9X0L4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLEKLVEMA RGKGKKLAVA AANDDHVIEA VYRAWRERVC EPVLFGPEEE
60 70 80 90 100
ITRIIEELVP EWKNPQIIDC PPEEAGRLAV EAVSKGECDF LMKGKIKTGD
110 120 130 140 150
LMKIYLDERY GLRTGKTMAM VSVMEIPDFP RPLIISDPGM LISPTLEQKV
160 170 180 190 200
DMIEHCVRVA NVMGLETPKV AVVGAIEVVN PKMPITMEAA ILSKMNQRGQ
210 220 230 240 250
IKGCIVDGPF ALDNVVSEEA AKKKGIQSPV AGKADILILP DIEAANILYK
260 270 280 290
ALVFLAKAKS ASTILGGKVP VVLTSRADSE ETKFYSIALS AVFA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | R → Y AA sequence (PubMed:10074080).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000512 Genomic DNA Translation: AAD36206.1 |
PIRi | G72293 |
RefSeqi | NP_228936.1, NC_000853.1 WP_004080280.1, NZ_CP011107.1 |
Genome annotation databases
EnsemblBacteriai | AAD36206; AAD36206; TM_1130 |
KEGGi | tma:TM1130 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000512 Genomic DNA Translation: AAD36206.1 |
PIRi | G72293 |
RefSeqi | NP_228936.1, NC_000853.1 WP_004080280.1, NZ_CP011107.1 |
3D structure databases
SMRi | Q9X0L4 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-2900N |
STRINGi | 243274.THEMA_08695 |
Genome annotation databases
EnsemblBacteriai | AAD36206; AAD36206; TM_1130 |
KEGGi | tma:TM1130 |
Phylogenomic databases
eggNOGi | COG0280, Bacteria |
InParanoidi | Q9X0L4 |
OMAi | CIVDGPF |
OrthoDBi | 1301815at2 |
Enzyme and pathway databases
UniPathwayi | UPA00340;UER00459 |
BioCyci | MetaCyc:MONOMER-427 |
Family and domain databases
InterProi | View protein in InterPro IPR012147, P_Ac_Bu_trans IPR002505, PTA_PTB |
Pfami | View protein in Pfam PF01515, PTA_PTB, 1 hit |
PIRSFi | PIRSF000428, P_Ac_trans, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTAS_THEMA | |
Accessioni | Q9X0L4Primary (citable) accession number: Q9X0L4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families