UniProtKB - Q9X013 (MTNA_THEMA)
Protein
Methylthioribose-1-phosphate isomerase
Gene
mtnA
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Functioni
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation
Catalytic activityi
- EC:5.3.1.23UniRule annotation
: L-methionine biosynthesis via salvage pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotationProteins known to be involved in the 6 steps of the subpathway in this organism are:
- Methylthioribose-1-phosphate isomerase (mtnA), Methylthioribose-1-phosphate isomerase (mtnA)
- no protein annotated in this organism
- no protein annotated in this organism
- no protein annotated in this organism
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 88 | Substrate | 1 | |
Sitei | 154 | Transition state stabilizerUniRule annotation | 1 | |
Binding sitei | 193 | SubstrateUniRule annotation | 1 | |
Active sitei | 234 | Proton donorUniRule annotation | 1 |
GO - Molecular functioni
- S-methyl-5-thioribose-1-phosphate isomerase activity Source: GO_Central
GO - Biological processi
- L-methionine salvage from methylthioadenosine Source: GO_Central
- L-methionine salvage from S-adenosylmethionine Source: UniProtKB-UniRule
Keywordsi
Molecular function | Isomerase |
Biological process | Amino-acid biosynthesis, Methionine biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00904;UER00874 |
Names & Taxonomyi
Protein namesi | Recommended name: Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)Short name: M1PiUniRule annotation Short name: MTR-1-P isomeraseUniRule annotation Alternative name(s): S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation |
Gene namesi | Name:mtnAUniRule annotation Ordered Locus Names:TM_0911 |
Organismi | Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) |
Taxonomic identifieri | 243274 [NCBI] |
Taxonomic lineagei | Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156094 | 1 – 343 | Methylthioribose-1-phosphate isomeraseAdd BLAST | 343 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9X013 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9X013 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 48 – 50 | Substrate binding | 3 | |
Regioni | 244 – 245 | Substrate binding | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0182, Bacteria |
InParanoidi | Q9X013 |
OMAi | CETRPLN |
OrthoDBi | 1290468at2 |
Family and domain databases
Gene3Di | 1.20.120.420, 1 hit 3.40.50.10470, 1 hit |
HAMAPi | MF_01678, Salvage_MtnA, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR005251, IF-M1Pi IPR042529, IF_2B-like_C IPR011559, Initiation_fac_2B_a/b/d IPR027363, M1Pi_N IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00524, eIF-2B_rel, 1 hit TIGR00512, salvage_mtnA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9X013-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLKTKTMEW SGNSLKLLDQ RKLPFIEEYV ECKTHEEVAH AIKEMIVRGA
60 70 80 90 100
PAIGVAAAFG YVLGLRDYKT GSLTDWMKQV KETLARTRPT AVNLFWALNR
110 120 130 140 150
MEKVFFENAD RENLFEILEN EALKMAYEDI EVNKAIGKNG AQLIKDGSTI
160 170 180 190 200
LTHCNAGALA TVDYGTALGV IRAAVESGKR IRVFADETRP YLQGARLTAW
210 220 230 240 250
ELMKDGIEVY VITDNMAGWL MKRGLIDAVV VGADRIALNG DTANKIGTYS
260 270 280 290 300
LAVLAKRNNI PFYVAAPVST IDPTIRSGEE IPIEERRPEE VTHCGGNRIA
310 320 330 340
PEGVKVLNPA FDVTENTLIT AIITEKGVIR PPFEENIKKI LEV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000512 Genomic DNA Translation: AAD35992.1 |
PIRi | F72319 |
RefSeqi | NP_228719.1, NC_000853.1 WP_004080652.1, NZ_CP011107.1 |
Genome annotation databases
EnsemblBacteriai | AAD35992; AAD35992; TM_0911 |
KEGGi | tma:TM0911 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000512 Genomic DNA Translation: AAD35992.1 |
PIRi | F72319 |
RefSeqi | NP_228719.1, NC_000853.1 WP_004080652.1, NZ_CP011107.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1T9K | X-ray | 2.60 | A/B/C/D | 1-343 | [»] | |
SMRi | Q9X013 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 243274.THEMA_00080 |
Genome annotation databases
EnsemblBacteriai | AAD35992; AAD35992; TM_0911 |
KEGGi | tma:TM0911 |
Phylogenomic databases
eggNOGi | COG0182, Bacteria |
InParanoidi | Q9X013 |
OMAi | CETRPLN |
OrthoDBi | 1290468at2 |
Enzyme and pathway databases
UniPathwayi | UPA00904;UER00874 |
Miscellaneous databases
EvolutionaryTracei | Q9X013 |
Family and domain databases
Gene3Di | 1.20.120.420, 1 hit 3.40.50.10470, 1 hit |
HAMAPi | MF_01678, Salvage_MtnA, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR005251, IF-M1Pi IPR042529, IF_2B-like_C IPR011559, Initiation_fac_2B_a/b/d IPR027363, M1Pi_N IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00524, eIF-2B_rel, 1 hit TIGR00512, salvage_mtnA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTNA_THEMA | |
Accessioni | Q9X013Primary (citable) accession number: Q9X013 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families