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Entry version 131 (10 Apr 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Riboflavin biosynthesis protein

Gene

TM_0857

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: FAD biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FAD from FMN.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin biosynthesis protein (Tmari_0859), Riboflavin biosynthesis protein (TM_0857)
This subpathway is part of the pathway FAD biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FAD from FMN, the pathway FAD biosynthesis and in Cofactor biosynthesis.

Pathwayi: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (ATP route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin biosynthesis protein (Tmari_0859), Riboflavin biosynthesis protein (TM_0857)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (ATP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei135AMP; via carbonyl oxygenCombined sources1
Binding sitei215FMNCombined sources1
Binding sitei264FMNCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi7 – 8AMPCombined sources2
Nucleotide bindingi12 – 15AMPCombined sources4
Nucleotide bindingi99 – 101AMPCombined sources3
Nucleotide bindingi127 – 128AMPCombined sources2
Nucleotide bindingi179 – 182ADPCombined sources4
Nucleotide bindingi231 – 242ADPCombined sourcesAdd BLAST12
Nucleotide bindingi255 – 258FMNCombined sources4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • FMN adenylyltransferase activity Source: UniProtKB-UniRule
  • riboflavin kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationImported, NucleotidyltransferaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, FADUniRule annotation, Flavoprotein, FMNUniRule annotationCombined sources, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
TMAR243274:G1H0Q-70-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00276;UER00406

UPA00277;UER00407

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Riboflavin biosynthesis proteinUniRule annotation
Including the following 2 domains:
Riboflavin kinaseUniRule annotation (EC:2.7.1.26UniRule annotation)
Alternative name(s):
FlavokinaseUniRule annotation
FMN adenylyltransferaseUniRule annotation (EC:2.7.7.2UniRule annotation)
Alternative name(s):
FAD pyrophosphorylaseUniRule annotation
FAD synthaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:TM_0857Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243274 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008183 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB04345 7,8-dimethylalloxazine
DB04272 Citric Acid
DB03247 Flavin mononucleotide

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MRZX-ray1.90A/B1-293[»]
1S4MX-ray2.10A/B1-293[»]
1T6XX-ray2.29A/B1-293[»]
1T6YX-ray2.80A/B1-293[»]
1T6ZX-ray2.40A/B1-293[»]
2I1LX-ray2.50A/B1-293[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9WZW1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ribF family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DTN Bacteria
COG0196 LUCA

KEGG Orthology (KO)

More...
KOi
K11753

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRGHQAI

Database of Orthologous Groups

More...
OrthoDBi
1504821at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02064 FAD_synthetase_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.30.30, 1 hit
3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015864 FAD_synthase
IPR023468 Riboflavin_kinase
IPR002606 Riboflavin_kinase_bac
IPR015865 Riboflavin_kinase_bac/euk
IPR023465 Riboflavin_kinase_dom_sf
IPR014729 Rossmann-like_a/b/a_fold

The PANTHER Classification System

More...
PANTHERi
PTHR22749 PTHR22749, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06574 FAD_syn, 1 hit
PF01687 Flavokinase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004491 FAD_Synth, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00904 Flavokinase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82114 SSF82114, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00083 ribF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9WZW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVSIGVFDG VHIGHQKVLR TMKEIAFFRK DDSLIYTISY PPEYFLPDFP
60 70 80 90 100
GLLMTVESRV EMLSRYARTV VLDFFRIKDL TPEGFVERYL SGVSAVVVGR
110 120 130 140 150
DFRFGKNASG NASFLRKKGV EVYEIEDVVV QGKRVSSSLI RNLVQEGRVE
160 170 180 190 200
EIPAYLGRYF EIEGIVHKDR EFGRKLGFPT ANIDRGNEKL VDLKRGVYLV
210 220 230 240 250
RVHLPDGKKK FGVMNVGFRP TVGDARNVKY EVYILDFEGD LYGQRLKLEV
260 270 280 290
LKFMRDEKKF DSIEELKAAI DQDVKSARNM IDDIINSKFE KEG
Length:293
Mass (Da):33,614
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42B56B582C03BEB4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD35939.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B72325

NCBI Reference Sequences

More...
RefSeqi
NP_228666.1, NC_000853.1
WP_004080749.1, NZ_CP011107.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD35939; AAD35939; TM_0857
AGL49784; AGL49784; Tmari_0859

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
898530

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tma:TM0857
tmi:THEMA_00350
tmw:THMA_0879

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|243274.17.peg.858

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD35939.1
PIRiB72325
RefSeqiNP_228666.1, NC_000853.1
WP_004080749.1, NZ_CP011107.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MRZX-ray1.90A/B1-293[»]
1S4MX-ray2.10A/B1-293[»]
1T6XX-ray2.29A/B1-293[»]
1T6YX-ray2.80A/B1-293[»]
1T6ZX-ray2.40A/B1-293[»]
2I1LX-ray2.50A/B1-293[»]
SMRiQ9WZW1
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB04345 7,8-dimethylalloxazine
DB04272 Citric Acid
DB03247 Flavin mononucleotide

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35939; AAD35939; TM_0857
AGL49784; AGL49784; Tmari_0859
GeneIDi898530
KEGGitma:TM0857
tmi:THEMA_00350
tmw:THMA_0879
PATRICifig|243274.17.peg.858

Phylogenomic databases

eggNOGiENOG4105DTN Bacteria
COG0196 LUCA
KOiK11753
OMAiHRGHQAI
OrthoDBi1504821at2

Enzyme and pathway databases

UniPathwayi
UPA00276;UER00406

UPA00277;UER00407

BioCyciTMAR243274:G1H0Q-70-MONOMER

Family and domain databases

CDDicd02064 FAD_synthetase_N, 1 hit
Gene3Di2.40.30.30, 1 hit
3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR015864 FAD_synthase
IPR023468 Riboflavin_kinase
IPR002606 Riboflavin_kinase_bac
IPR015865 Riboflavin_kinase_bac/euk
IPR023465 Riboflavin_kinase_dom_sf
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR22749 PTHR22749, 1 hit
PfamiView protein in Pfam
PF06574 FAD_syn, 1 hit
PF01687 Flavokinase, 1 hit
PIRSFiPIRSF004491 FAD_Synth, 1 hit
SMARTiView protein in SMART
SM00904 Flavokinase, 1 hit
SUPFAMiSSF82114 SSF82114, 1 hit
TIGRFAMsiTIGR00083 ribF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9WZW1_THEMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WZW1
Secondary accession number(s): G4FCW7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: April 10, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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