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Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.1 Publication

Temperature dependencei

Optimum temperature is 75 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21ATP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei276ATPBy similarity1
Binding sitei341ATPBy similarity1
Binding sitei413ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 68ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease ATPase subunit HslU
Alternative name(s):
Unfoldase HslU
Gene namesi
Name:hslU
Ordered Locus Names:TM_0522
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001605551 – 463ATP-dependent protease ATPase subunit HslUAdd BLAST463

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP (By similarity).By similarity

Protein-protein interaction databases

STRINGi243274.TM0522

Structurei

3D structure databases

ProteinModelPortaliQ9WYZ2
SMRiQ9WYZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family. HslU subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C4N Bacteria
COG1220 LUCA
InParanoidiQ9WYZ2
KOiK03667
OMAiKYGMIKT

Family and domain databases

HAMAPiMF_00249 HslU, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004491 HslU
IPR027417 P-loop_NTPase
PANTHERiPTHR43815 PTHR43815, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF07724 AAA_2, 1 hit
PF10431 ClpB_D2-small, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01086 ClpB_D2-small, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00390 hslU, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WYZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSFDEMTPK EIVQELDKYI VGQYEAKKAV AIAVRNRIRR QKLPEEWRKE
60 70 80 90 100
VLPKNILMIG PTGVGKTEIA RRLAQLSGSP FLKVEATRFT EVGYVGKNVD
110 120 130 140 150
SMIRDLVEIS VNMVKQEKIK EVERQAEELV EERILDALVP ESKAMPVVTN
160 170 180 190 200
PFINLITGGQ QQQYTPEDRR RFRAKREEMR EKLRKGELED EEIEIELEET
210 220 230 240 250
VSPFMGIFGP GMEDLGIEIT NMFSGMLPKR KKKRKMKVSE ARKVLLPLEA
260 270 280 290 300
EKLIDMDKVV QEALDRAQNR GIIFIDEIDK IAGKESAVGP DVSRQGVQRD
310 320 330 340 350
LLPIVEGTTI MTKYGPVRTD FILFIAAGAF HVSRPSDLIP ELQGRFPIRV
360 370 380 390 400
ELSPLTEEDF VRILKEPENA IIKQYQALLS TEGVELVFTE DGIREMARIA
410 420 430 440 450
YQLNQRLENI GARRLYTVAE KVLEEISFEA PDIPEKRVVV DAEYVRRRLE
460
KIVQDEDLSA YIL
Length:463
Mass (Da):53,052
Last modified:November 1, 1999 - v1
Checksum:iF871CD909FCBA5CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD35607.1
PIRiH72365
RefSeqiNP_228332.1, NC_000853.1
WP_004081401.1, NZ_CP011107.1

Genome annotation databases

EnsemblBacteriaiAAD35607; AAD35607; TM_0522
GeneIDi897573
KEGGitma:TM0522

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD35607.1
PIRiH72365
RefSeqiNP_228332.1, NC_000853.1
WP_004081401.1, NZ_CP011107.1

3D structure databases

ProteinModelPortaliQ9WYZ2
SMRiQ9WYZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0522

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35607; AAD35607; TM_0522
GeneIDi897573
KEGGitma:TM0522

Phylogenomic databases

eggNOGiENOG4105C4N Bacteria
COG1220 LUCA
InParanoidiQ9WYZ2
KOiK03667
OMAiKYGMIKT

Family and domain databases

HAMAPiMF_00249 HslU, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004491 HslU
IPR027417 P-loop_NTPase
PANTHERiPTHR43815 PTHR43815, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF07724 AAA_2, 1 hit
PF10431 ClpB_D2-small, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01086 ClpB_D2-small, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00390 hslU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSLU_THEMA
AccessioniPrimary (citable) accession number: Q9WYZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 10, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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