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Protein

Transaldolase

Gene

tal

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Does not show fructose-6-P aldolase activity.1 Publication

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.1 Publication

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable transaldolase (tal), Transaldolase (tal)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPentose shunt
LigandSchiff base

Enzyme and pathway databases

BRENDAi2.2.1.2 6331
UniPathwayi
UPA00115;UER00414

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:tal
Ordered Locus Names:TM_0295
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001736871 – 218TransaldolaseAdd BLAST218

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0295

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9WYD1
SMRiQ9WYD1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WYD1

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 3B subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CW3 Bacteria
COG0176 LUCA
InParanoidiQ9WYD1
KOiK00616
OMAiVRHPMHV

Family and domain databases

CDDicd00956 Transaldolase_FSA, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00494 Transaldolase_3b, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR022999 Transaldolase_3B
IPR004731 Transaldolase_3B/F6P_aldolase
IPR018225 Transaldolase_AS
IPR033919 TSA/FSA_arc/bac
PANTHERiPTHR10683 PTHR10683, 2 hits
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00875 fsa_talC_mipB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WYD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIFLDTANL EEIKKGVEWG IVDGVTTNPT LISKEGAEFK QRVKEICDLV
60 70 80 90 100
KGPVSAEVVS LDYEGMVREA RELAQISEYV VIKIPMTPDG IKAVKTLSAE
110 120 130 140 150
GIKTNVTLVF SPAQAILAAK AGATYVSPFV GRMDDLSNDG MRMLGEIVEI
160 170 180 190 200
YNNYGFETEI IAASIRHPMH VVEAALMGVD IVTMPFAVLE KLFKHPMTDL
210
GIERFMEDWK KYLENLKK
Length:218
Mass (Da):24,213
Last modified:November 1, 1999 - v1
Checksum:i3FF8B0A85CFA6EFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD35383.1
PIRiG72394
RefSeqiNP_228107.1, NC_000853.1
WP_004083013.1, NZ_CP011107.1

Genome annotation databases

EnsemblBacteriaiAAD35383; AAD35383; TM_0295
GeneIDi897220
KEGGitma:TM0295

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000512 Genomic DNA Translation: AAD35383.1
PIRiG72394
RefSeqiNP_228107.1, NC_000853.1
WP_004083013.1, NZ_CP011107.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VPXX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T1-218[»]
ProteinModelPortaliQ9WYD1
SMRiQ9WYD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0295

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35383; AAD35383; TM_0295
GeneIDi897220
KEGGitma:TM0295

Phylogenomic databases

eggNOGiENOG4105CW3 Bacteria
COG0176 LUCA
InParanoidiQ9WYD1
KOiK00616
OMAiVRHPMHV

Enzyme and pathway databases

UniPathwayi
UPA00115;UER00414

BRENDAi2.2.1.2 6331

Miscellaneous databases

EvolutionaryTraceiQ9WYD1

Family and domain databases

CDDicd00956 Transaldolase_FSA, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00494 Transaldolase_3b, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR022999 Transaldolase_3B
IPR004731 Transaldolase_3B/F6P_aldolase
IPR018225 Transaldolase_AS
IPR033919 TSA/FSA_arc/bac
PANTHERiPTHR10683 PTHR10683, 2 hits
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00875 fsa_talC_mipB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAL_THEMA
AccessioniPrimary (citable) accession number: Q9WYD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: November 1, 1999
Last modified: October 10, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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