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Protein

Inducible T-cell costimulator

Gene

Icos

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).By similarity3 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-388841 Costimulation by the CD28 family
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Inducible T-cell costimulator
Alternative name(s):
Activation-inducible lymphocyte immunomediatory molecule
CD28 and CTLA-4-like protein
Short name:
CCLP
CD28-related protein 1
Short name:
CRP-1
CD_antigen: CD278
Gene namesi
Name:Icos
Synonyms:Ailim
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1858745 Icos

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 144ExtracellularSequence analysisAdd BLAST124
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 200CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001480721 – 200Inducible T-cell costimulatorAdd BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi42 ↔ 109By similarity
Disulfide bondi63 ↔ 83By similarity
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9WVS0
PaxDbiQ9WVS0
PRIDEiQ9WVS0

PTM databases

iPTMnetiQ9WVS0
PhosphoSitePlusiQ9WVS0

Expressioni

Tissue specificityi

Expressed on activated T-cells and resting memory T-cells. High expression seen in the thymic medulla and in the germinal centers and T-cell zones of lymph nodes and Peyer patches. Expressed at low levels in the spleen.3 Publications

Gene expression databases

BgeeiENSMUSG00000026009 Expressed in 57 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_ICOS
ExpressionAtlasiQ9WVS0 baseline and differential
GenevisibleiQ9WVS0 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Pik3r1P264502EBI-16721736,EBI-641764

Protein-protein interaction databases

IntActiQ9WVS0, 2 interactors
STRINGi10090.ENSMUSP00000099891

Structurei

3D structure databases

ProteinModelPortaliQ9WVS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 133Ig-like V-typeAdd BLAST104

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J005 Eukaryota
ENOG41117EH LUCA
GeneTreeiENSGT00390000000801
HOGENOMiHOG000112996
HOVERGENiHBG052079
InParanoidiQ9WVS0
KOiK06713
TreeFamiTF335679

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF15910 V-set_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WVS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPYFCRVFV FCFLIRLLTG EINGSADHRM FSFHNGGVQI SCKYPETVQQ
60 70 80 90 100
LKMRLFRERE VLCELTKTKG SGNAVSIKNP MLCLYHLSNN SVSFFLNNPD
110 120 130 140 150
SSQGSYYFCS LSIFDPPPFQ ERNLSGGYLH IYESQLCCQL KLWLPVGCAA
160 170 180 190 200
FVVVLLFGCI LIIWFSKKKY GSSVHDPNSE YMFMAAVNTN KKSRLAGVTS
Length:200
Mass (Da):22,709
Last modified:July 19, 2004 - v2
Checksum:i87D97F0DC44ADCA7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SUZ8Q5SUZ8_MOUSE
Inducible T-cell costimulator
Icos
223Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7R → H (PubMed:11006126).Curated1
Sequence conflicti7R → H (PubMed:10760791).Curated1
Sequence conflicti7R → H (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216748 mRNA Translation: AAF45150.1
AB023132 mRNA Translation: BAA82126.1
AJ250559 mRNA Translation: CAB71153.1
AF327185, AF327184 Genomic DNA Translation: AAG48732.1
AF257230 mRNA Translation: AAF70099.1
BC034852 mRNA Translation: AAH34852.1
CCDSiCCDS14994.1
RefSeqiNP_059508.2, NM_017480.2
XP_006496201.1, XM_006496138.1
XP_006496202.1, XM_006496139.1
UniGeneiMm.42044

Genome annotation databases

EnsembliENSMUST00000102827; ENSMUSP00000099891; ENSMUSG00000026009
GeneIDi54167
KEGGimmu:54167
UCSCiuc011wlz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216748 mRNA Translation: AAF45150.1
AB023132 mRNA Translation: BAA82126.1
AJ250559 mRNA Translation: CAB71153.1
AF327185, AF327184 Genomic DNA Translation: AAG48732.1
AF257230 mRNA Translation: AAF70099.1
BC034852 mRNA Translation: AAH34852.1
CCDSiCCDS14994.1
RefSeqiNP_059508.2, NM_017480.2
XP_006496201.1, XM_006496138.1
XP_006496202.1, XM_006496139.1
UniGeneiMm.42044

3D structure databases

ProteinModelPortaliQ9WVS0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVS0, 2 interactors
STRINGi10090.ENSMUSP00000099891

PTM databases

iPTMnetiQ9WVS0
PhosphoSitePlusiQ9WVS0

Proteomic databases

EPDiQ9WVS0
PaxDbiQ9WVS0
PRIDEiQ9WVS0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102827; ENSMUSP00000099891; ENSMUSG00000026009
GeneIDi54167
KEGGimmu:54167
UCSCiuc011wlz.2 mouse

Organism-specific databases

CTDi29851
MGIiMGI:1858745 Icos

Phylogenomic databases

eggNOGiENOG410J005 Eukaryota
ENOG41117EH LUCA
GeneTreeiENSGT00390000000801
HOGENOMiHOG000112996
HOVERGENiHBG052079
InParanoidiQ9WVS0
KOiK06713
TreeFamiTF335679

Enzyme and pathway databases

ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-388841 Costimulation by the CD28 family
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

PROiPR:Q9WVS0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026009 Expressed in 57 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_ICOS
ExpressionAtlasiQ9WVS0 baseline and differential
GenevisibleiQ9WVS0 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF15910 V-set_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiICOS_MOUSE
AccessioniPrimary (citable) accession number: Q9WVS0
Secondary accession number(s): Q9JL17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 10, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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