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Protein

Fragile X mental retardation syndrome-related protein 2

Gene

Fxr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fragile X mental retardation syndrome-related protein 2
Gene namesi
Name:Fxr2
Synonyms:Fxr2h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1346074 Fxr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501111 – 673Fragile X mental retardation syndrome-related protein 2Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphotyrosineBy similarity1
Modified residuei192PhosphoserineBy similarity1
Modified residuei413PhosphothreonineCombined sources1
Modified residuei452PhosphoserineBy similarity1
Modified residuei455PhosphoserineBy similarity1
Modified residuei465PhosphoserineBy similarity1
Modified residuei534PhosphoserineBy similarity1
Modified residuei567PhosphoserineBy similarity1
Modified residuei581PhosphoserineBy similarity1
Modified residuei599PhosphothreonineBy similarity1
Modified residuei602PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WVR4
MaxQBiQ9WVR4
PaxDbiQ9WVR4
PeptideAtlasiQ9WVR4
PRIDEiQ9WVR4

PTM databases

iPTMnetiQ9WVR4
PhosphoSitePlusiQ9WVR4

Expressioni

Gene expression databases

CleanExiMM_FXR2

Interactioni

Subunit structurei

Interacts with FMR1 (By similarity). Interacts with FXR1 (By similarity). Interacts with TDRD3 (By similarity). Interacts with HABP4 (By similarity). Interacts with CYFIP2 but not with CYFIP1 (PubMed:11438699).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WVR4, 7 interactors
MINTiQ9WVR4
STRINGi10090.ENSMUSP00000018909

Structurei

3D structure databases

ProteinModelPortaliQ9WVR4
SMRiQ9WVR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 60Agenet-like 1PROSITE-ProRule annotationAdd BLAST47
Domaini73 – 125Agenet-like 2PROSITE-ProRule annotationAdd BLAST53
Domaini228 – 276KH 1PROSITE-ProRule annotationAdd BLAST49
Domaini291 – 340KH 2PROSITE-ProRule annotationAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi416 – 420Poly-Ser5
Compositional biasi483 – 486Poly-Arg4
Compositional biasi545 – 553Poly-Arg9
Compositional biasi585 – 595Poly-ArgAdd BLAST11

Domaini

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.By similarity

Sequence similaritiesi

Belongs to the FMR1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF9J Eukaryota
ENOG410ZDJG LUCA
HOVERGENiHBG005739
InParanoidiQ9WVR4

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR008395 Agenet-like_dom
IPR022034 FXMRP1_C_core
IPR032172 FXR_C1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF05641 Agenet, 1 hit
PF12235 FXMRP1_C_core, 1 hit
PF16096 FXR_C1, 1 hit
PF00013 KH_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 2 hits
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS51641 AGENET_LIKE, 2 hits
PS50084 KH_TYPE_1, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WVR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGLASGGDV EPGLPVEVRG SNGAFYKGFV KDVHEDSVTI FFENNWQSER
60 70 80 90 100
QIPFGDVRLP PPADYNKEIT EGDEVEVYSR ANEQEPCGWC LARVRMMKGD
110 120 130 140 150
FYVIEYAACD ATYNEIVTLE RLRPVNSSSL ATKGSFFKVT MAVPEDLREA
160 170 180 190 200
CSNENVHKEF KKALGANCIF LNITNSELFI LSTTEAPVKR ASLLGDMHFR
210 220 230 240 250
SLRTKLLLMS RNEEATKHLE TSKQLAAAFQ EEFTVREDLM GLAIGTHGAN
260 270 280 290 300
IQQARKVPGV TAIELGEETC TFRIYGETPE ACRQARSYLE FSEDSVQVPR
310 320 330 340 350
DLVGKVTGKT GKVIQGIVDK SGVVRVRVEG DNDKKNPKEG GMVPFIFVGT
360 370 380 390 400
RENISNAQAL LEYHLSYLQE VETLRLERLQ IDEQLRQIGA GFRPPGSGRG
410 420 430 440 450
GSGGGSDKAG YTTDESSSSS LHTTRTYGGS YGGRGRGRRT GGPAYGPSSD
460 470 480 490 500
PSTASETESE KREESNRAGP GDRDPPSRGE ESRRRRLGPG KGPPPVPRPT
510 520 530 540 550
SRYNSSSISS VLKDPDSNPY SLLDTSEPEP PVDSEPGEPP PASARRRRSR
560 570 580 590 600
RRRTDEDRTV MDGALESDGP NMTENGLEDE SRPQRRNRSR RRRNRGNRTD
610 620 630 640 650
GSISGDRQPV TVADYISRAE SQSRQRPLGR TEPSEDSLSG QKGDSVSKLP
660 670
KGPSENGELS APLELGSLVN GVS
Length:673
Mass (Da):73,743
Last modified:November 1, 1999 - v1
Checksum:i01F6814D4C3B5654
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P5B5Q6P5B5_MOUSE
Fragile X mental retardation syndro...
Fxr2 Fxr2h
674Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025269 mRNA Translation: BAA82147.1
AB025311 Genomic DNA Translation: BAA82249.1
UniGeneiMm.41930

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025269 mRNA Translation: BAA82147.1
AB025311 Genomic DNA Translation: BAA82249.1
UniGeneiMm.41930

3D structure databases

ProteinModelPortaliQ9WVR4
SMRiQ9WVR4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVR4, 7 interactors
MINTiQ9WVR4
STRINGi10090.ENSMUSP00000018909

PTM databases

iPTMnetiQ9WVR4
PhosphoSitePlusiQ9WVR4

Proteomic databases

EPDiQ9WVR4
MaxQBiQ9WVR4
PaxDbiQ9WVR4
PeptideAtlasiQ9WVR4
PRIDEiQ9WVR4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1346074 Fxr2

Phylogenomic databases

eggNOGiENOG410IF9J Eukaryota
ENOG410ZDJG LUCA
HOVERGENiHBG005739
InParanoidiQ9WVR4

Miscellaneous databases

ChiTaRSiFxr2 mouse
PROiPR:Q9WVR4
SOURCEiSearch...

Gene expression databases

CleanExiMM_FXR2

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR008395 Agenet-like_dom
IPR022034 FXMRP1_C_core
IPR032172 FXR_C1
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF05641 Agenet, 1 hit
PF12235 FXMRP1_C_core, 1 hit
PF16096 FXR_C1, 1 hit
PF00013 KH_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 2 hits
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS51641 AGENET_LIKE, 2 hits
PS50084 KH_TYPE_1, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFXR2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVR4
Secondary accession number(s): Q9WVR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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