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Protein

Interferon-induced GTP-binding protein Mx2

Gene

Mx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV) and Hantaan virus (HNTV).2 Publications

Miscellaneous

The Mx2 gene is non-functional in all laboratory mouse strains examined. It is functional in feral strains.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi70 – 77GTPSequence analysis8
Nucleotide bindingi171 – 175GTPSequence analysis5
Nucleotide bindingi240 – 243GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx2
Alternative name(s):
Myxovirus resistance protein 2
Gene namesi
Name:Mx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:97244 Mx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065991 – 655Interferon-induced GTP-binding protein Mx2Add BLAST655

Proteomic databases

MaxQBiQ9WVP9
PaxDbiQ9WVP9
PRIDEiQ9WVP9

PTM databases

iPTMnetiQ9WVP9
PhosphoSitePlusiQ9WVP9

Expressioni

Inductioni

By type I and type III interferons.2 Publications

Gene expression databases

BgeeiENSMUSG00000023341
CleanExiMM_MX2
GenevisibleiQ9WVP9 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WVP9, 1 interactor
STRINGi10090.ENSMUSP00000024112

Structurei

3D structure databases

ProteinModelPortaliQ9WVP9
SMRiQ9WVP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 333Dynamin-type GPROSITE-ProRule annotationAdd BLAST274
Domaini567 – 655GEDPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 77G1 motifPROSITE-ProRule annotation8
Regioni95 – 97G2 motifPROSITE-ProRule annotation3
Regioni171 – 174G3 motifPROSITE-ProRule annotation4
Regioni240 – 243G4 motifPROSITE-ProRule annotation4
Regioni272 – 275G5 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOGENOMiHOG000063238
HOVERGENiHBG008788
InParanoidiQ9WVP9
KOiK14754
PhylomeDBiQ9WVP9
TreeFamiTF331484

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WVP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSTEENTG VDSVNLPSGE TGLGEKDQES VNNLCSQYEE KVRPCIDLID
60 70 80 90 100
SLRALGVEQD LALPAIAVIG DQSSGKSSVL EALSGVALPR GSGIVTRCPL
110 120 130 140 150
VLKLRKLNEG EEWRGKVSYD DIEVELSDPS EVEEAINKGQ NFIAGVGLGI
160 170 180 190 200
SDKLISLDVS SPNVPDLTLI DLPGITRVAV GNQPADIGRQ IKRLIKTYIQ
210 220 230 240 250
KQETINLVVV PSNVDIATTE ALSMAQEVDP EGDRTIGILT KPDLVDRGTE
260 270 280 290 300
DKVVDVVRNL VYHLKKGYMI VKCRGQQDIQ EQLSLTEALQ NEQIFFKEHP
310 320 330 340 350
HFRVLLEDGK ATVPCLAERL TAELISHICK SLPLLENQIK ESHQSASEEL
360 370 380 390 400
QKYGMDIPED DSEKTFFLIE KINAFNQDIT ALVQGEENVA EGECRLFTRL
410 420 430 440 450
RKEFLSWSKE IEKNFAKGYA VLYNEVWAFE KQYRGRELPG FVNYKTFENI
460 470 480 490 500
IRRQIKTLEE PAIEMLHTVT EIVRAAFTSV SEKNFSEFYN LHRTTKSKLE
510 520 530 540 550
DIRLEQEKEA EMSIRLHFKM EQIIYCQDQI YRGALQKVRE EEAEEEKKTK
560 570 580 590 600
HGTSSSSQSQ DLQTSSMAEI FQHLNAYRQE AHNRISSHVP LIIQYFILKM
610 620 630 640 650
FAERLQKGML QLLQDKDSCS WLLKEQSDTS EKRKFLKERL ARLAQARRRL

AKFPG
Length:655
Mass (Da):74,292
Last modified:April 26, 2005 - v2
Checksum:i9F58BD9D0E9349C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326S → L in BAA82593 (PubMed:10233954).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029920 mRNA Translation: BAA82593.1
BC007127 mRNA Translation: AAH07127.1
RefSeqiNP_038634.1, NM_013606.1
UniGeneiMm.14157

Genome annotation databases

EnsembliENSMUST00000024112; ENSMUSP00000024112; ENSMUSG00000023341
GeneIDi17858
KEGGimmu:17858

Similar proteinsi

Entry informationi

Entry nameiMX2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVP9
Secondary accession number(s): Q922L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 18, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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