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Protein

AP-1 complex subunit mu-2

Gene

Ap1m2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

GO - Biological processi

  • intracellular protein transport Source: MGI
  • vesicle-mediated transport Source: MGI

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit mu-2
Alternative name(s):
AP-mu chain family member mu1B
Adaptor protein complex AP-1 subunit mu-2
Adaptor-related protein complex 1 subunit mu-2
Clathrin assembly protein complex 1 mu-2 medium chain 2
Golgi adaptor HA1/AP1 adaptin mu-2 subunit
Mu-adaptin 2
Mu1B-adaptin
Gene namesi
Name:Ap1m2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1336974 Ap1m2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937731 – 423AP-1 complex subunit mu-2Add BLAST423

Post-translational modificationi

Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9WVP1
PeptideAtlasiQ9WVP1
PRIDEiQ9WVP1

PTM databases

iPTMnetiQ9WVP1
PhosphoSitePlusiQ9WVP1

Expressioni

Gene expression databases

CleanExiMM_AP1M2

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).1 Publication

Protein-protein interaction databases

IntActiQ9WVP1, 1 interactor
MINTiQ9WVP1
STRINGi10090.ENSMUSP00000111093

Structurei

3D structure databases

ProteinModelPortaliQ9WVP1
SMRiQ9WVP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 421MHDPROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0937 Eukaryota
ENOG410XPFS LUCA
HOGENOMiHOG000173247
HOVERGENiHBG050516
InParanoidiQ9WVP1
KOiK12393
PhylomeDBiQ9WVP1
TreeFamiTF300393

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9WVP1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSASAVFILD VKGKPLISRN YKGDVPMTEI DHFMPLLMQR EEEGVLAPLL
60 70 80 90 100
SHGRVHFLWI KHSNLYLVAT TLKNANASLV YSFLYKTVEV FCEYFKELEE
110 120 130 140 150
ESIRDNFVIV YDLLDELMDF GFPQTTDSKI LQEYITQQGN KLETGKSRVP
160 170 180 190 200
PTVTNAVSWR SEGIKYKKNE VFIDVIESVN LLVNANGSVL LSEIVGTIKL
210 220 230 240 250
KVFLSGMPEL RLGLNDRVLF ELTGRSKNKS VELEDVKFHQ CVRLSRFDND
260 270 280 290 300
RTISFIPPDG DFELMSYRLS TQVKPLIWIE SVIEKFSHSR VEIMVKAKGQ
310 320 330 340 350
FKKQSVANGV EISVPVPSDA DSPRFKTSVG SAKYVPEKNV VIWSIKSFPG
360 370 380 390 400
GKEYLMRAHF GLPSVETEEV EGRPPIGVKF EIPYFTVSGI QVRYMKIIEK
410 420
SGYQALPWVR YITQSGDYQL RTS
Length:423
Mass (Da):48,137
Last modified:January 23, 2007 - v3
Checksum:iFD18049309F074B5
GO
Isoform 2 (identifier: Q9WVP1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-225: R → LSG

Note: No experimental confirmation available.
Show »
Length:425
Mass (Da):48,238
Checksum:i094BC463C49B7D87
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1L4A0A0R4J1L4_MOUSE
AP-1 complex subunit mu-2
Ap1m2 mCG_14036
425Annotation score:
A0A0R4IZX6A0A0R4IZX6_MOUSE
AP-1 complex subunit mu-2
Ap1m2 mCG_14036
423Annotation score:
A0A1L1SUA0A0A1L1SUA0_MOUSE
AP-1 complex subunit mu-2
Ap1m2
224Annotation score:
A0A1L1SQU9A0A1L1SQU9_MOUSE
AP-1 complex subunit mu-2
Ap1m2
195Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112D → E in BAB26971 (PubMed:16141072).Curated1
Sequence conflicti112D → E in AAH03704 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000170225R → LSG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067146 mRNA Translation: AAD28085.1
AF139416
, AF139406, AF139407, AF139408, AF139409, AF139410, AF139411, AF139412, AF139413, AF139414, AF139415 Genomic DNA Translation: AAF61815.1
AK010478 mRNA Translation: BAB26971.1
BC003704 mRNA Translation: AAH03704.1
CCDSiCCDS22902.1 [Q9WVP1-1]
CCDS52734.1 [Q9WVP1-2]
RefSeqiNP_001103770.1, NM_001110300.1
NP_033808.2, NM_009678.2
UniGeneiMm.22239

Genome annotation databases

GeneIDi11768
KEGGimmu:11768
UCSCiuc009okx.2 mouse [Q9WVP1-1]
uc009oky.2 mouse [Q9WVP1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067146 mRNA Translation: AAD28085.1
AF139416
, AF139406, AF139407, AF139408, AF139409, AF139410, AF139411, AF139412, AF139413, AF139414, AF139415 Genomic DNA Translation: AAF61815.1
AK010478 mRNA Translation: BAB26971.1
BC003704 mRNA Translation: AAH03704.1
CCDSiCCDS22902.1 [Q9WVP1-1]
CCDS52734.1 [Q9WVP1-2]
RefSeqiNP_001103770.1, NM_001110300.1
NP_033808.2, NM_009678.2
UniGeneiMm.22239

3D structure databases

ProteinModelPortaliQ9WVP1
SMRiQ9WVP1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVP1, 1 interactor
MINTiQ9WVP1
STRINGi10090.ENSMUSP00000111093

PTM databases

iPTMnetiQ9WVP1
PhosphoSitePlusiQ9WVP1

Proteomic databases

PaxDbiQ9WVP1
PeptideAtlasiQ9WVP1
PRIDEiQ9WVP1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11768
KEGGimmu:11768
UCSCiuc009okx.2 mouse [Q9WVP1-1]
uc009oky.2 mouse [Q9WVP1-2]

Organism-specific databases

CTDi10053
MGIiMGI:1336974 Ap1m2

Phylogenomic databases

eggNOGiKOG0937 Eukaryota
ENOG410XPFS LUCA
HOGENOMiHOG000173247
HOVERGENiHBG050516
InParanoidiQ9WVP1
KOiK12393
PhylomeDBiQ9WVP1
TreeFamiTF300393

Miscellaneous databases

PROiPR:Q9WVP1
SOURCEiSearch...

Gene expression databases

CleanExiMM_AP1M2

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAP1M2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVP1
Secondary accession number(s): Q99LA4, Q9CWP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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