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Protein

Tolloid-like protein 2

Gene

Tll2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.

Cofactori

Zn2+PROSITE-ProRule annotationNote: Binds 1 zinc ion per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi239Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
Active sitei240PROSITE-ProRule annotation1
Metal bindingi243Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
Metal bindingi249Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of skeletal muscle tissue growth Source: MGI

Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Metalloprotease, Protease
Biological processDifferentiation
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils

Protein family/group databases

MEROPSiM12.018

Names & Taxonomyi

Protein namesi
Recommended name:
Tolloid-like protein 2 (EC:3.4.24.-)
Gene namesi
Name:Tll2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1346044 Tll2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000004603822 – 146By similarityAdd BLAST125
ChainiPRO_0000046039147 – 1012Tolloid-like protein 2Add BLAST866

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi189 ↔ 345PROSITE-ProRule annotation
Disulfide bondi209 ↔ 231PROSITE-ProRule annotation
Disulfide bondi211 ↔ 212PROSITE-ProRule annotation
Disulfide bondi348 ↔ 374By similarity
Glycosylationi358N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi389N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi401 ↔ 423By similarity
Disulfide bondi461 ↔ 487By similarity
Disulfide bondi514 ↔ 536By similarity
Disulfide bondi577 ↔ 589By similarity
Disulfide bondi585 ↔ 598By similarity
Disulfide bondi600 ↔ 613By similarity
Disulfide bondi617 ↔ 643By similarity
Glycosylationi625N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi670 ↔ 692By similarity
Disulfide bondi733 ↔ 744By similarity
Disulfide bondi740 ↔ 753By similarity
Disulfide bondi755 ↔ 768By similarity
Disulfide bondi773 ↔ 799By similarity
Glycosylationi802N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi826 ↔ 848By similarity
Disulfide bondi886 ↔ 916By similarity
Disulfide bondi943 ↔ 965By similarity
Modified residuei960Omega-N-methylarginineCombined sources1
Modified residuei963Omega-N-methylarginineCombined sources1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Methylation, Zymogen

Proteomic databases

MaxQBiQ9WVM6
PaxDbiQ9WVM6
PRIDEiQ9WVM6

PTM databases

iPTMnetiQ9WVM6
PhosphoSitePlusiQ9WVM6

Expressioni

Developmental stagei

Expressed at E7.5, in a limited way, in the posterior portion of the egg cylinder in the nascent mesoderm streaming off the primitive streak. At the distant end of the embryo cylinder, expression ended at the node. Later in the development, expression seems to be limited to developing skeletal muscle and central nervous system.1 Publication

Gene expression databases

BgeeiENSMUSG00000025013 Expressed in 9 organ(s), highest expression level in female gonad
CleanExiMM_TLL2
ExpressionAtlasiQ9WVM6 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025986

Structurei

3D structure databases

ProteinModelPortaliQ9WVM6
SMRiQ9WVM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 346Peptidase M12APROSITE-ProRule annotationAdd BLAST201
Domaini348 – 460CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini461 – 573CUB 2PROSITE-ProRule annotationAdd BLAST113
Domaini573 – 614EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini617 – 729CUB 3PROSITE-ProRule annotationAdd BLAST113
Domaini729 – 769EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini773 – 885CUB 4PROSITE-ProRule annotationAdd BLAST113
Domaini886 – 1002CUB 5PROSITE-ProRule annotationAdd BLAST117

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000236339
HOVERGENiHBG004859
InParanoidiQ9WVM6
KOiK13047
OMAiSSMFLRF
OrthoDBiEOG091G009U
PhylomeDBiQ9WVM6
TreeFamiTF314351

Family and domain databases

CDDicd00041 CUB, 5 hits
cd04281 ZnMc_BMP1_TLD, 1 hit
Gene3Di2.60.120.290, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR015446 BMP_1/tolloid-like
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR035914 Sperma_CUB_dom_sf
IPR034036 ZnMP_TLD/BMP1
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF00431 CUB, 5 hits
PF07645 EGF_CA, 1 hit
PIRSFiPIRSF001199 BMP_1/tolloid-like, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00042 CUB, 5 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF49854 SSF49854, 5 hits
PROSITEiView protein in PROSITE
PS51864 ASTACIN, 1 hit
PS01180 CUB, 5 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits
PS00142 ZINC_PROTEASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WVM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLATTLGTL VLLLLLPLPR GAEVTGDHSN VALDYGALEG EEGTEQQLHY
60 70 80 90 100
HDPCKAAVFW GDIALDEDDL KLFHIDKAED WTKPSIDKPG HDTGGLEETS
110 120 130 140 150
ARWPNDTASN ASIQAPRKDG KDATTFLPNP GTSNTTAKTF SARVRRATTS
160 170 180 190 200
RTERIWPGGV IPYVIGGNFT GTQRAIFKQA MRHWEKHTCV TFVERTDEES
210 220 230 240 250
FIVFSYRTCG CCSYVGRRGG GPQAISIGKN CDKFGIVAHE LGHVVGFWHE
260 270 280 290 300
HTRPDRDQHV TIIRENIQPG QEYNFLKMEA GEVSSLGETY DFDSIMHYAR
310 320 330 340 350
NTFSRGVFLD TILPRRDDNG VRPTIGQRVR LSQGDIAQAR KLYKCPACGE
360 370 380 390 400
TLQDTTGNFS APGFPNGYPS YSHCVWRISV TPGEKIILNF TSMDLFKSRL
410 420 430 440 450
CWYDYVEIRD GYWRKAPLLG RFCGDKIPES LVSSDSRLWV EFRSSSSSLG
460 470 480 490 500
KGFFAVYEAM CGGDITKDAG QIQSPNYPDD YRPSKECVWR ITVPDGFHVG
510 520 530 540 550
LTFQSFEIER HDSCAYDYLE IRDGPTEDST LIGHFCGYEK PEAVKSSANR
560 570 580 590 600
LWVKFVSDGS INKAGFAANF FKEVDECSWP DHGGCEQRCV NTLGSYTCAC
610 620 630 640 650
DPGYELAADK KTCEVACGGF ITKLNGTITS PGWPKEYPTN KNCVWQVVAP
660 670 680 690 700
VQYRISLQFE AFELEGNDVC KYDFVEVRSG LSPDAKLHGK FCGSETPEVI
710 720 730 740 750
TSQSNNMRVE FKSDNTVSKR GFRAHFFSDK DECAKDNGGC QQECVNTFGS
760 770 780 790 800
YLCRCRNGYR LHENGHDCKE AGCAYKISSA EGTLMSPNWP DKYPSRKECT
810 820 830 840 850
WNISSTAGHR VKITFSEFEI EQHQECAYDH LELYDGTDSL APILGRFCGS
860 870 880 890 900
KKPDPVVATG SSLFLRFYSD ASVQRKGFQA VHSTECGGRL KAEVQTKELY
910 920 930 940 950
SHAQFGDNNY PSQARCDWVI VAEDGYGVEL IFRTFEVEEE ADCGYDFMEA
960 970 980 990 1000
YDGYDSSAPR LGRFCGSGPL EEIYSAGDSL MIRFHTDDTI NKKGFHARYT
1010
STKFQDALHM RK
Length:1,012
Mass (Da):113,252
Last modified:November 1, 1999 - v1
Checksum:i72EEE268A4D8C5FE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q5B9E9Q5B9_MOUSE
Metalloendopeptidase
Tll2
995Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073526 mRNA Translation: AAD42993.1
BC132537 mRNA Translation: AAI32538.1
CCDSiCCDS37986.1
RefSeqiNP_036034.1, NM_011904.3
UniGeneiMm.89983

Genome annotation databases

EnsembliENSMUST00000025986; ENSMUSP00000025986; ENSMUSG00000025013
GeneIDi24087
KEGGimmu:24087
UCSCiuc008hlr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073526 mRNA Translation: AAD42993.1
BC132537 mRNA Translation: AAI32538.1
CCDSiCCDS37986.1
RefSeqiNP_036034.1, NM_011904.3
UniGeneiMm.89983

3D structure databases

ProteinModelPortaliQ9WVM6
SMRiQ9WVM6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025986

Protein family/group databases

MEROPSiM12.018

PTM databases

iPTMnetiQ9WVM6
PhosphoSitePlusiQ9WVM6

Proteomic databases

MaxQBiQ9WVM6
PaxDbiQ9WVM6
PRIDEiQ9WVM6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025986; ENSMUSP00000025986; ENSMUSG00000025013
GeneIDi24087
KEGGimmu:24087
UCSCiuc008hlr.1 mouse

Organism-specific databases

CTDi7093
MGIiMGI:1346044 Tll2

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000236339
HOVERGENiHBG004859
InParanoidiQ9WVM6
KOiK13047
OMAiSSMFLRF
OrthoDBiEOG091G009U
PhylomeDBiQ9WVM6
TreeFamiTF314351

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils

Miscellaneous databases

PROiPR:Q9WVM6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025013 Expressed in 9 organ(s), highest expression level in female gonad
CleanExiMM_TLL2
ExpressionAtlasiQ9WVM6 baseline and differential

Family and domain databases

CDDicd00041 CUB, 5 hits
cd04281 ZnMc_BMP1_TLD, 1 hit
Gene3Di2.60.120.290, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR015446 BMP_1/tolloid-like
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR035914 Sperma_CUB_dom_sf
IPR034036 ZnMP_TLD/BMP1
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF00431 CUB, 5 hits
PF07645 EGF_CA, 1 hit
PIRSFiPIRSF001199 BMP_1/tolloid-like, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00042 CUB, 5 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF49854 SSF49854, 5 hits
PROSITEiView protein in PROSITE
PS51864 ASTACIN, 1 hit
PS01180 CUB, 5 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTLL2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVM6
Secondary accession number(s): A2RTK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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