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Protein

Anaphase-promoting complex subunit 7

Gene

Anapc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-MMU-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase
R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-MMU-176412 Phosphorylation of the APC/C
R-MMU-179409 APC-Cdc20 mediated degradation of Nek2A
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 7
Short name:
APC7
Alternative name(s):
Cyclosome subunit 7
Prediabetic NOD sera-reactive autoantigen
Gene namesi
Name:Anapc7
Synonyms:Apc7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1929711 Anapc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001062621 – 565Anaphase-promoting complex subunit 7Add BLAST565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9WVM3
MaxQBiQ9WVM3
PaxDbiQ9WVM3
PRIDEiQ9WVM3

PTM databases

iPTMnetiQ9WVM3
PhosphoSitePlusiQ9WVM3

Expressioni

Gene expression databases

BgeeiENSMUSG00000029466 Expressed in 275 organ(s), highest expression level in ear vesicle
CleanExiMM_ANAPC7
ExpressionAtlasiQ9WVM3 baseline and differential
GenevisibleiQ9WVM3 MM

Interactioni

Subunit structurei

V-shaped homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207898, 6 interactors
CORUMiQ9WVM3
IntActiQ9WVM3, 3 interactors
MINTiQ9WVM3
STRINGi10090.ENSMUSP00000031422

Structurei

3D structure databases

ProteinModelPortaliQ9WVM3
SMRiQ9WVM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati101 – 134TPR 1Add BLAST34
Repeati169 – 202TPR 2Add BLAST34
Repeati203 – 236TPR 3Add BLAST34
Repeati237 – 270TPR 4Add BLAST34
Repeati339 – 372TPR 5Add BLAST34
Repeati373 – 406TPR 6Add BLAST34
Repeati407 – 439TPR 7Add BLAST33
Repeati442 – 474TPR 8Add BLAST33
Repeati475 – 508TPR 9Add BLAST34
Repeati509 – 531TPR 10Add BLAST23

Sequence similaritiesi

Belongs to the APC7 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1174 Eukaryota
ENOG410XS2B LUCA
GeneTreeiENSGT00390000005482
HOGENOMiHOG000007393
HOVERGENiHBG050529
InParanoidiQ9WVM3
KOiK03354
OMAiCYEGLID
OrthoDBiEOG091G07W7
PhylomeDBiQ9WVM3
TreeFamiTF105445

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9WVM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVIDHVRDM AAAGLHSNVR LLSSLLLTMS NNNPELFSPS QKYQLLVYHA
60 70 80 90 100
DSLFHDKEYR NAVSKYAMAL QQKKALSKTS KVRPSTGNSA STPQSQCLPS
110 120 130 140 150
EIEVKYKMAE CYTMLKLDKD AIAVLDGIPS RQRTPKINMM LANLYKKAGQ
160 170 180 190 200
ERPSVTSYKE VLRQCPLALD AILGLLSLSV KGAEVASMTM NVIQTVPNLD
210 220 230 240 250
WLSVWIKAYA FVHTGDNSRA INTICSLEKK SLLRDNVDLL GSLADLYFRA
260 270 280 290 300
GDSKNSVLKF EQAQMLDPYL IRGMDVYGYL LAREGRLEDV ENLGCRLFNI
310 320 330 340 350
SDQHAEPWVV SGCHSFYSKR YSRALYLGAK AIQLNSNSVQ ALLLKGAALR
360 370 380 390 400
NMGRVQEAII HFREAIRLAP CRLDCYEGLI ECYLASNSIR EAMVMANNVY
410 420 430 440 450
KTLGANAQTL TLLATVCLED PVTQEKAKTL LDKALAQRPD YVKAVVKKAE
460 470 480 490 500
LLSREQKYED GIALLRNALA NQSDCVLHRI LGDFLVAVNE YQEAMDQYSI
510 520 530 540 550
ALSLDPNDQK SLEGMQKMEK EESPTDATQE EDVDDMEGSG EEGDLEGSDS
560
EAAQWADQEQ WFGMQ
Length:565
Mass (Da):63,021
Last modified:October 3, 2003 - v3
Checksum:iF7DFB8D45FDCD639
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YU58D3YU58_MOUSE
Anaphase-promoting complex subunit ...
Anapc7
503Annotation score:
F6WXH0F6WXH0_MOUSE
Anaphase-promoting complex subunit ...
Anapc7
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156T → A in AAD39343 (PubMed:10515598).Curated1
Sequence conflicti188M → T in AAD39343 (PubMed:10515598).Curated1
Sequence conflicti288E → K in BAC27131 (PubMed:16141072).Curated1
Sequence conflicti340Q → K in BAC27131 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076607 mRNA Translation: AAD39343.2
AK030775 mRNA Translation: BAC27131.1
AK150764 mRNA Translation: BAE29831.1
AK150891 mRNA Translation: BAE29937.1
AK153114 mRNA Translation: BAE31731.1
AK159523 mRNA Translation: BAE35152.1
AK164202 mRNA Translation: BAE37680.1
BC006635 mRNA Translation: AAH06635.1
CCDSiCCDS19649.1
RefSeqiNP_062779.3, NM_019805.4
UniGeneiMm.37341

Genome annotation databases

EnsembliENSMUST00000031422; ENSMUSP00000031422; ENSMUSG00000029466
ENSMUST00000122010; ENSMUSP00000113928; ENSMUSG00000029466
GeneIDi56317
KEGGimmu:56317
UCSCiuc008zlh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076607 mRNA Translation: AAD39343.2
AK030775 mRNA Translation: BAC27131.1
AK150764 mRNA Translation: BAE29831.1
AK150891 mRNA Translation: BAE29937.1
AK153114 mRNA Translation: BAE31731.1
AK159523 mRNA Translation: BAE35152.1
AK164202 mRNA Translation: BAE37680.1
BC006635 mRNA Translation: AAH06635.1
CCDSiCCDS19649.1
RefSeqiNP_062779.3, NM_019805.4
UniGeneiMm.37341

3D structure databases

ProteinModelPortaliQ9WVM3
SMRiQ9WVM3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207898, 6 interactors
CORUMiQ9WVM3
IntActiQ9WVM3, 3 interactors
MINTiQ9WVM3
STRINGi10090.ENSMUSP00000031422

PTM databases

iPTMnetiQ9WVM3
PhosphoSitePlusiQ9WVM3

Proteomic databases

EPDiQ9WVM3
MaxQBiQ9WVM3
PaxDbiQ9WVM3
PRIDEiQ9WVM3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031422; ENSMUSP00000031422; ENSMUSG00000029466
ENSMUST00000122010; ENSMUSP00000113928; ENSMUSG00000029466
GeneIDi56317
KEGGimmu:56317
UCSCiuc008zlh.2 mouse

Organism-specific databases

CTDi51434
MGIiMGI:1929711 Anapc7

Phylogenomic databases

eggNOGiKOG1174 Eukaryota
ENOG410XS2B LUCA
GeneTreeiENSGT00390000005482
HOGENOMiHOG000007393
HOVERGENiHBG050529
InParanoidiQ9WVM3
KOiK03354
OMAiCYEGLID
OrthoDBiEOG091G07W7
PhylomeDBiQ9WVM3
TreeFamiTF105445

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-MMU-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase
R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-MMU-176412 Phosphorylation of the APC/C
R-MMU-179409 APC-Cdc20 mediated degradation of Nek2A
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q9WVM3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029466 Expressed in 275 organ(s), highest expression level in ear vesicle
CleanExiMM_ANAPC7
ExpressionAtlasiQ9WVM3 baseline and differential
GenevisibleiQ9WVM3 MM

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPC7_MOUSE
AccessioniPrimary (citable) accession number: Q9WVM3
Secondary accession number(s): Q3UBM7, Q8BSR2, Q91W13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: November 7, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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