UniProtKB - Q9WVM3 (APC7_MOUSE)
Protein
Anaphase-promoting complex subunit 7
Gene
Anapc7
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- protein phosphatase binding Source: MGI
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: GO_Central
- cell division Source: GO_Central
- metaphase/anaphase transition of mitotic cell cycle Source: GO_Central
- positive regulation of mitotic metaphase/anaphase transition Source: GO_Central
- protein K11-linked ubiquitination Source: UniProtKB
- protein ubiquitination Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-MMU-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-MMU-176408, Regulation of APC/C activators between G1/S and early anaphase R-MMU-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-MMU-176412, Phosphorylation of the APC/C R-MMU-179409, APC-Cdc20 mediated degradation of Nek2A R-MMU-2467813, Separation of Sister Chromatids R-MMU-2559582, Senescence-Associated Secretory Phenotype (SASP) R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Anaphase-promoting complex subunit 7Short name: APC7 Alternative name(s): Cyclosome subunit 7 Prediabetic NOD sera-reactive autoantigen |
Gene namesi | Name:Anapc7 Synonyms:Apc7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929711, Anapc7 |
Subcellular locationi
Nucleus
- anaphase-promoting complex Source: UniProtKB
- nucleus Source: MGI
Other locations
- cytoplasm Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106262 | 1 – 565 | Anaphase-promoting complex subunit 7Add BLAST | 565 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 229 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9WVM3 |
MaxQBi | Q9WVM3 |
PaxDbi | Q9WVM3 |
PRIDEi | Q9WVM3 |
PTM databases
iPTMneti | Q9WVM3 |
PhosphoSitePlusi | Q9WVM3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029466, Expressed in ear vesicle and 292 other tissues |
Genevisiblei | Q9WVM3, MM |
Interactioni
Subunit structurei
V-shaped homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.
By similarityGO - Molecular functioni
- protein phosphatase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 207898, 6 interactors |
CORUMi | Q9WVM3 |
IntActi | Q9WVM3, 3 interactors |
MINTi | Q9WVM3 |
STRINGi | 10090.ENSMUSP00000113928 |
Miscellaneous databases
RNActi | Q9WVM3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 101 – 134 | TPR 1Add BLAST | 34 | |
Repeati | 169 – 202 | TPR 2Add BLAST | 34 | |
Repeati | 203 – 236 | TPR 3Add BLAST | 34 | |
Repeati | 237 – 270 | TPR 4Add BLAST | 34 | |
Repeati | 339 – 372 | TPR 5Add BLAST | 34 | |
Repeati | 373 – 406 | TPR 6Add BLAST | 34 | |
Repeati | 407 – 439 | TPR 7Add BLAST | 33 | |
Repeati | 442 – 474 | TPR 8Add BLAST | 33 | |
Repeati | 475 – 508 | TPR 9Add BLAST | 34 | |
Repeati | 509 – 531 | TPR 10Add BLAST | 23 |
Sequence similaritiesi
Belongs to the APC7 family.Curated
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1174, Eukaryota |
GeneTreei | ENSGT00950000182950 |
HOGENOMi | CLU_026953_2_0_1 |
InParanoidi | Q9WVM3 |
OMAi | HAGDNQR |
OrthoDBi | 808566at2759 |
PhylomeDBi | Q9WVM3 |
TreeFami | TF105445 |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 5 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9WVM3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVIDHVRDM AAAGLHSNVR LLSSLLLTMS NNNPELFSPS QKYQLLVYHA
60 70 80 90 100
DSLFHDKEYR NAVSKYAMAL QQKKALSKTS KVRPSTGNSA STPQSQCLPS
110 120 130 140 150
EIEVKYKMAE CYTMLKLDKD AIAVLDGIPS RQRTPKINMM LANLYKKAGQ
160 170 180 190 200
ERPSVTSYKE VLRQCPLALD AILGLLSLSV KGAEVASMTM NVIQTVPNLD
210 220 230 240 250
WLSVWIKAYA FVHTGDNSRA INTICSLEKK SLLRDNVDLL GSLADLYFRA
260 270 280 290 300
GDSKNSVLKF EQAQMLDPYL IRGMDVYGYL LAREGRLEDV ENLGCRLFNI
310 320 330 340 350
SDQHAEPWVV SGCHSFYSKR YSRALYLGAK AIQLNSNSVQ ALLLKGAALR
360 370 380 390 400
NMGRVQEAII HFREAIRLAP CRLDCYEGLI ECYLASNSIR EAMVMANNVY
410 420 430 440 450
KTLGANAQTL TLLATVCLED PVTQEKAKTL LDKALAQRPD YVKAVVKKAE
460 470 480 490 500
LLSREQKYED GIALLRNALA NQSDCVLHRI LGDFLVAVNE YQEAMDQYSI
510 520 530 540 550
ALSLDPNDQK SLEGMQKMEK EESPTDATQE EDVDDMEGSG EEGDLEGSDS
560
EAAQWADQEQ WFGMQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YU58 | D3YU58_MOUSE | Anaphase-promoting complex subunit ... | Anapc7 | 503 | Annotation score: | ||
F6WXH0 | F6WXH0_MOUSE | Anaphase-promoting complex subunit ... | Anapc7 | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 156 | T → A in AAD39343 (PubMed:10515598).Curated | 1 | |
Sequence conflicti | 188 | M → T in AAD39343 (PubMed:10515598).Curated | 1 | |
Sequence conflicti | 288 | E → K in BAC27131 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 340 | Q → K in BAC27131 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF076607 mRNA Translation: AAD39343.2 AK030775 mRNA Translation: BAC27131.1 AK150764 mRNA Translation: BAE29831.1 AK150891 mRNA Translation: BAE29937.1 AK153114 mRNA Translation: BAE31731.1 AK159523 mRNA Translation: BAE35152.1 AK164202 mRNA Translation: BAE37680.1 BC006635 mRNA Translation: AAH06635.1 |
CCDSi | CCDS19649.1 |
RefSeqi | NP_062779.3, NM_019805.4 |
Genome annotation databases
Ensembli | ENSMUST00000031422; ENSMUSP00000031422; ENSMUSG00000029466 ENSMUST00000122010; ENSMUSP00000113928; ENSMUSG00000029466 |
GeneIDi | 56317 |
KEGGi | mmu:56317 |
UCSCi | uc008zlh.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF076607 mRNA Translation: AAD39343.2 AK030775 mRNA Translation: BAC27131.1 AK150764 mRNA Translation: BAE29831.1 AK150891 mRNA Translation: BAE29937.1 AK153114 mRNA Translation: BAE31731.1 AK159523 mRNA Translation: BAE35152.1 AK164202 mRNA Translation: BAE37680.1 BC006635 mRNA Translation: AAH06635.1 |
CCDSi | CCDS19649.1 |
RefSeqi | NP_062779.3, NM_019805.4 |
3D structure databases
SMRi | Q9WVM3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207898, 6 interactors |
CORUMi | Q9WVM3 |
IntActi | Q9WVM3, 3 interactors |
MINTi | Q9WVM3 |
STRINGi | 10090.ENSMUSP00000113928 |
PTM databases
iPTMneti | Q9WVM3 |
PhosphoSitePlusi | Q9WVM3 |
Proteomic databases
EPDi | Q9WVM3 |
MaxQBi | Q9WVM3 |
PaxDbi | Q9WVM3 |
PRIDEi | Q9WVM3 |
Protocols and materials databases
Antibodypediai | 4033, 90 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000031422; ENSMUSP00000031422; ENSMUSG00000029466 ENSMUST00000122010; ENSMUSP00000113928; ENSMUSG00000029466 |
GeneIDi | 56317 |
KEGGi | mmu:56317 |
UCSCi | uc008zlh.2, mouse |
Organism-specific databases
CTDi | 51434 |
MGIi | MGI:1929711, Anapc7 |
Phylogenomic databases
eggNOGi | KOG1174, Eukaryota |
GeneTreei | ENSGT00950000182950 |
HOGENOMi | CLU_026953_2_0_1 |
InParanoidi | Q9WVM3 |
OMAi | HAGDNQR |
OrthoDBi | 808566at2759 |
PhylomeDBi | Q9WVM3 |
TreeFami | TF105445 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-MMU-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-MMU-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-MMU-176408, Regulation of APC/C activators between G1/S and early anaphase R-MMU-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-MMU-176412, Phosphorylation of the APC/C R-MMU-179409, APC-Cdc20 mediated degradation of Nek2A R-MMU-2467813, Separation of Sister Chromatids R-MMU-2559582, Senescence-Associated Secretory Phenotype (SASP) R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 56317, 0 hits in 17 CRISPR screens |
ChiTaRSi | Anapc7, mouse |
PROi | PR:Q9WVM3 |
RNActi | Q9WVM3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029466, Expressed in ear vesicle and 292 other tissues |
Genevisiblei | Q9WVM3, MM |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
InterProi | View protein in InterPro IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 5 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | APC7_MOUSE | |
Accessioni | Q9WVM3Primary (citable) accession number: Q9WVM3 Secondary accession number(s): Q3UBM7, Q8BSR2, Q91W13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | October 3, 2003 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families