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Entry version 169 (11 Dec 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Rac GTPase-activating protein 1

Gene

Racgap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri287 – 336Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, GTPase activation
Biological processCell cycle, Cell division, Differentiation, Ion transport, Spermatogenesis, Transport
LigandLipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-194840 Rho GTPase cycle
R-MMU-2132295 MHC class II antigen presentation
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rac GTPase-activating protein 1
Alternative name(s):
Male germ cell RacGap
Short name:
MgcRacGAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Racgap1Imported
Synonyms:Mgcracgap
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1349423 Racgap1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002288091 – 628Rac GTPase-activating protein 1Add BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei150Phosphoserine; by PLK1By similarity1
Modified residuei155PhosphoserineBy similarity1
Modified residuei158Phosphoserine; by PLK1By similarity1
Modified residuei162PhosphothreonineBy similarity1
Modified residuei165Phosphoserine; by PLK1By similarity1
Modified residuei171Phosphoserine; by PLK1By similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei215PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei258PhosphoserineBy similarity1
Modified residuei343PhosphothreonineBy similarity1
Modified residuei388Phosphoserine; by AURKBBy similarity1
Cross-linki405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei411Phosphoserine; by AURKBBy similarity1
Modified residuei564PhosphothreonineCombined sources1
Modified residuei577PhosphothreonineCombined sources1
Modified residuei585PhosphothreonineCombined sources1
Modified residuei602PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at multiple sites in the midbody during cytokinesis. Phosphorylation by AURKB on Ser-388 at the midbody is, at least in part, responsible for exerting its latent GAP activity towards RhoA. Phosphorylation on multiple serine residues by PLK1 enhances its association with ECT2 and is critical for cleavage furrow formation (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9WVM1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9WVM1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9WVM1

PeptideAtlas

More...
PeptideAtlasi
Q9WVM1

PRoteomics IDEntifications database

More...
PRIDEi
Q9WVM1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9WVM1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WVM1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis, thymus and spleen and weakly expressed in brain, heart, skeletal muscle and kidney. In testis, expression is restricted to germ cells with the highest levels of expression found in spermatocytes. Not detected in adult liver. Also expressed in fetal liver and in several hematopoietic cell lines.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 6.5 dpc expressed in primitive endoderm, embryonic ectoderm, extraembryonic ectoderm and the ectoplacental cone. By 7.5 dpc, a widespread expression was observed in all intra- and extraembryonic tissues and also in the giant cells lining the inner boundary of the deciduum. At 9.5 dpc, expression was elevated in the neuroepithelium of the brain ventricles and the neural tube. By 12.5 dpc, expression remains widespread and in the brain higher levels were observed in the ventricular zone of the two telencephalic lobes, and in the mesencephalon and diencephalon, with the exception of the median sulcus. In adult brain, highest levels of expression were detected in cerebellum, specifically the Purkinje cell layer extending into the molecular layer.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is down-regulated during macrophage differentiation of M1 cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000023015 Expressed in 256 organ(s), highest expression level in endocardial cushion

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9WVM1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9WVM1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two molecules each of RACGAP1 and KIF23.

Found in the centralspindlin complex composed of RACGAP1 and KIF23. Associates with alpha-, beta- and gamma-tubulin and microtubules.

Interacts via its Rho-GAP domain with RND2. Associates with AURKB during M phase.

Interacts via its Rho-GAP domain and basic region with PRC1. The interaction with PRC1 inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology.

Interacts with SLC26A8 via its N-terminus.

Interacts with RAB11FIP3.

Interacts with ECT2; the interaction is direct, occurs at anaphase and during cytokinesis in a microtubule-dependent manner and is enhanced by phosphorylation by PLK1.

Interacts with KIF23; the interaction is direct (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
205072, 42 interactors

Database of interacting proteins

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DIPi
DIP-42340N

Protein interaction database and analysis system

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IntActi
Q9WVM1, 46 interactors

Molecular INTeraction database

More...
MINTi
Q9WVM1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000023756

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9WVM1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9WVM1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini350 – 540Rho-GAPPROSITE-ProRule annotationAdd BLAST191

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni107 – 286Interaction with SLC26A8By similarityAdd BLAST180

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili33 – 110Sequence analysisAdd BLAST78

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled coil region is indispensible for localization to the midbody during cytokinesis.By similarity
The phorbol-ester/DAG-type zinc finger domain mediates interaction with membranes enriched in phosphatidylinositol 3,4,5-trisphosphate and is required during mitotic cytokinesis for normal attachment of the midbody to the cell membrane.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri287 – 336Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3564 Eukaryota
ENOG410XPK0 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154610

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230702

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9WVM1

KEGG Orthology (KO)

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KOi
K16733

Identification of Orthologs from Complete Genome Data

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OMAi
IRELLMC

Database of Orthologous Groups

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OrthoDBi
372767at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9WVM1

TreeFam database of animal gene trees

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TreeFami
TF318102

Family and domain databases

Conserved Domains Database

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CDDi
cd00029 C1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002219 PE/DAG-bd
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF00130 C1_1, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00109 C1, 1 hit
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9WVM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTTMVNLWT LFEQLVRRME IINEGNESIE FIQVVKDFED FRKKYQRTNQ
60 70 80 90 100
ELEKFKDLLL KAETGRSALD VKLKHARNQV DVEIKRRQRA EAECAKLEQQ
110 120 130 140 150
IQLIRDILMC DTSGSIQLSE EQKSALAFLN RGQASSGHAG NNRLSTIDES
160 170 180 190 200
GSILSDISFD KTDESLDWDS SLVKNFKMKK REKRRSNSRQ FIDGPPGPVK
210 220 230 240 250
KTCSIGSTVD QANESIVAKT TVTVPSDGGP IEAVSTIETL PSWTRSRGKS
260 270 280 290 300
GPLQPVNSDS ALNSRPLEPR TDTDNLGTPQ NTGGMRLHDF VSKTVIKPES
310 320 330 340 350
CVPCGKRIKF GKLSLKCRDC RLVSHPECRD RCPLPCIPPL VGTPVKIGEG
360 370 380 390 400
MLADFVSQAS PMIPAIVVSC VNEIEQRGLT EAGLYRISGC DRTVKELKEK
410 420 430 440 450
FLKVKTVPLL SKVDDIHVIC SLLKDFLRNL KEPLLTFWLS KAFMEAAEIT
460 470 480 490 500
DEDNSTAAMY QAVSELPQAN RDTLAFLMIH LQRVSQSPDT KMDIANLAKV
510 520 530 540 550
FGPTIVAHTV PNPDPVTMFQ DIKRQLKVVE RLLSLPLEYW NQFMMVDQEN
560 570 580 590 600
IDSQRGNGNS TPRTPDVKVS LLGPVTTPEF QLVKTPLSSS LSQRLYNLSK
610 620
STPRFGNKSK SATNLGQQGK FFPAPYLK
Length:628
Mass (Da):70,158
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D1B9DEC3CE057BE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q9N9E9Q9N9_MOUSE
Rac GTPase-activating protein 1
Racgap1
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q071E9Q071_MOUSE
Rac GTPase-activating protein 1
Racgap1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q851E9Q851_MOUSE
Rac GTPase-activating protein 1
Racgap1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WD40F6WD40_MOUSE
Rac GTPase-activating protein 1
Racgap1
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q1Y6E9Q1Y6_MOUSE
Rac GTPase-activating protein 1
Racgap1
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29 – 31IEF → MES in BAE38561 (PubMed:16141072).Curated3
Sequence conflicti100Q → E in BAE40131 (PubMed:16141072).Curated1
Sequence conflicti100Q → E in BAE40010 (PubMed:16141072).Curated1
Sequence conflicti398K → E in BAE40005 (PubMed:16141072).Curated1
Sequence conflicti623P → T in BAE40005 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF079974 mRNA Translation: AAD40487.1
AB030252 mRNA Translation: BAA90248.1
AF212320 mRNA Translation: AAG43539.1
AF212321 mRNA Translation: AAG43540.1
AK144608 mRNA Translation: BAE25967.1
AK154929 mRNA Translation: BAE32931.1
AK165897 mRNA Translation: BAE38446.1
AK166084 mRNA Translation: BAE38561.1
AK168020 mRNA Translation: BAE40005.1
AK168025 mRNA Translation: BAE40010.1
AK168170 mRNA Translation: BAE40131.1
AK168679 mRNA Translation: BAE40528.1
BC010715 mRNA Translation: AAH10715.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS27825.1

NCBI Reference Sequences

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RefSeqi
NP_001240737.1, NM_001253808.1
NP_001240738.1, NM_001253809.1
NP_036155.1, NM_012025.7
XP_011243948.1, XM_011245646.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000023756; ENSMUSP00000023756; ENSMUSG00000023015
ENSMUST00000171702; ENSMUSP00000126417; ENSMUSG00000023015

Database of genes from NCBI RefSeq genomes

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GeneIDi
26934

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:26934

UCSC genome browser

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UCSCi
uc007xpx.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079974 mRNA Translation: AAD40487.1
AB030252 mRNA Translation: BAA90248.1
AF212320 mRNA Translation: AAG43539.1
AF212321 mRNA Translation: AAG43540.1
AK144608 mRNA Translation: BAE25967.1
AK154929 mRNA Translation: BAE32931.1
AK165897 mRNA Translation: BAE38446.1
AK166084 mRNA Translation: BAE38561.1
AK168020 mRNA Translation: BAE40005.1
AK168025 mRNA Translation: BAE40010.1
AK168170 mRNA Translation: BAE40131.1
AK168679 mRNA Translation: BAE40528.1
BC010715 mRNA Translation: AAH10715.1
CCDSiCCDS27825.1
RefSeqiNP_001240737.1, NM_001253808.1
NP_001240738.1, NM_001253809.1
NP_036155.1, NM_012025.7
XP_011243948.1, XM_011245646.1

3D structure databases

SMRiQ9WVM1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi205072, 42 interactors
DIPiDIP-42340N
IntActiQ9WVM1, 46 interactors
MINTiQ9WVM1
STRINGi10090.ENSMUSP00000023756

PTM databases

iPTMnetiQ9WVM1
PhosphoSitePlusiQ9WVM1

Proteomic databases

EPDiQ9WVM1
MaxQBiQ9WVM1
PaxDbiQ9WVM1
PeptideAtlasiQ9WVM1
PRIDEiQ9WVM1

Genome annotation databases

EnsembliENSMUST00000023756; ENSMUSP00000023756; ENSMUSG00000023015
ENSMUST00000171702; ENSMUSP00000126417; ENSMUSG00000023015
GeneIDi26934
KEGGimmu:26934
UCSCiuc007xpx.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29127
MGIiMGI:1349423 Racgap1

Phylogenomic databases

eggNOGiKOG3564 Eukaryota
ENOG410XPK0 LUCA
GeneTreeiENSGT00940000154610
HOGENOMiHOG000230702
InParanoidiQ9WVM1
KOiK16733
OMAiIRELLMC
OrthoDBi372767at2759
PhylomeDBiQ9WVM1
TreeFamiTF318102

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle
R-MMU-2132295 MHC class II antigen presentation
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Racgap1 mouse

Protein Ontology

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PROi
PR:Q9WVM1
RNActiQ9WVM1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000023015 Expressed in 256 organ(s), highest expression level in endocardial cushion
ExpressionAtlasiQ9WVM1 baseline and differential
GenevisibleiQ9WVM1 MM

Family and domain databases

CDDicd00029 C1, 1 hit
Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR002219 PE/DAG-bd
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGAP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WVM1
Secondary accession number(s): Q3THR5, Q3TI41, Q3TM81
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1999
Last modified: December 11, 2019
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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