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Protein

C-X-C motif chemokine 15

Gene

Cxcl15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic for neutrophils. Involved in lung-specific neutrophil trafficking during normal and inflammatory conditions.1 Publication

GO - Molecular functioni

  • chemokine activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 15
Alternative name(s):
Lungkine
Small-inducible cytokine B15
Gene namesi
Name:Cxcl15
Synonyms:Scyb15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1339941 Cxcl15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice develop normally and are fertile. They display normal leukocyte subpopulations in peripheral blood and bone marrow, but the amount of neutrophils is reduced in the airspace. Susceptibility to pneumonia induced by K.pneumoniae is increased with decreased survival and increased bacterial burden in lung.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000511726 – 167C-X-C motif chemokine 15Add BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 57By similarity
Disulfide bondi32 ↔ 73By similarity
Modified residuei157PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ9WVL7
PaxDbiQ9WVL7
PeptideAtlasiQ9WVL7
PRIDEiQ9WVL7

PTM databases

iPTMnetiQ9WVL7

Expressioni

Tissue specificityi

Expression restricted to the lung, produced by bronchoepithelial cells and is released into the airways. Expressed at low levels in fetal lung.2 Publications

Inductioni

By inflammation; in lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000029375 Expressed in 63 organ(s), highest expression level in left lung lobe
CleanExiMM_CXCL15
GenevisibleiQ9WVL7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WVL7, 1 interactor
MINTiQ9WVL7
STRINGi10090.ENSMUSP00000031322

Structurei

3D structure databases

ProteinModelPortaliQ9WVL7
SMRiQ9WVL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3HC Eukaryota
ENOG410Z1BP LUCA
GeneTreeiENSGT00930000151564
HOVERGENiHBG079169
InParanoidiQ9WVL7
KOiK10034
OrthoDBiEOG091G0YLH
PhylomeDBiQ9WVL7
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQGWSMLL LAVLNLGIFV RPCDTQELRC LCIQEHSEFI PLKLIKNIMV
60 70 80 90 100
IFETIYCNRK EVIAVPKNGS MICLDPDAPW VKATVGPITN RFLPEDLKQK
110 120 130 140 150
EFPPAMKLLY SVEHEKPLYL SFGRPENKRI FPFPIRETSR HFADLAHNSD
160
RNFLRDSSEV SLTGSDA
Length:167
Mass (Da):19,091
Last modified:November 1, 1999 - v1
Checksum:iB9A724505FFDA5A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082859 mRNA Translation: AAD38079.1
AK142955 mRNA Translation: BAE25229.1
CH466617 Genomic DNA Translation: EDL05302.1
BC061138 mRNA Translation: AAH61138.1
CCDSiCCDS19418.1
RefSeqiNP_035469.1, NM_011339.2
UniGeneiMm.64326

Genome annotation databases

EnsembliENSMUST00000031322; ENSMUSP00000031322; ENSMUSG00000029375
GeneIDi20309
KEGGimmu:20309
UCSCiuc008ybk.1 mouse

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082859 mRNA Translation: AAD38079.1
AK142955 mRNA Translation: BAE25229.1
CH466617 Genomic DNA Translation: EDL05302.1
BC061138 mRNA Translation: AAH61138.1
CCDSiCCDS19418.1
RefSeqiNP_035469.1, NM_011339.2
UniGeneiMm.64326

3D structure databases

ProteinModelPortaliQ9WVL7
SMRiQ9WVL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVL7, 1 interactor
MINTiQ9WVL7
STRINGi10090.ENSMUSP00000031322

PTM databases

iPTMnetiQ9WVL7

Proteomic databases

MaxQBiQ9WVL7
PaxDbiQ9WVL7
PeptideAtlasiQ9WVL7
PRIDEiQ9WVL7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031322; ENSMUSP00000031322; ENSMUSG00000029375
GeneIDi20309
KEGGimmu:20309
UCSCiuc008ybk.1 mouse

Organism-specific databases

CTDi20309
MGIiMGI:1339941 Cxcl15

Phylogenomic databases

eggNOGiENOG410J3HC Eukaryota
ENOG410Z1BP LUCA
GeneTreeiENSGT00930000151564
HOVERGENiHBG079169
InParanoidiQ9WVL7
KOiK10034
OrthoDBiEOG091G0YLH
PhylomeDBiQ9WVL7
TreeFamiTF333433

Miscellaneous databases

PROiPR:Q9WVL7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029375 Expressed in 63 organ(s), highest expression level in left lung lobe
CleanExiMM_CXCL15
GenevisibleiQ9WVL7 MM

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXL15_MOUSE
AccessioniPrimary (citable) accession number: Q9WVL7
Secondary accession number(s): Q3UQ15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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