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Entry version 130 (29 Sep 2021)
Sequence version 1 (01 Nov 1999)
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Protein

MORC family CW-type zinc finger protein 1

Gene

Morc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for spermatogenesis (PubMed:10369865, PubMed:25503965).

Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (PubMed:25503965).

Not required for piRNA biosynthesis (PubMed:25503965).

2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi485ZincPROSITE-ProRule annotation1
Metal bindingi488ZincPROSITE-ProRule annotation1
Metal bindingi511ZincPROSITE-ProRule annotation1
Metal bindingi522ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri465 – 530CW-typePROSITE-ProRule annotationAdd BLAST66

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, RNA-mediated gene silencing, Spermatogenesis
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MORC family CW-type zinc finger protein 1
Alternative name(s):
Protein microrchidia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Morc1Imported
Synonyms:MorcImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1316740, Morc1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000022652

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show progressive loss of spermatogonia and male infertility (PubMed:10369865, PubMed:25503965). Spermatogenesis is blocked early in meiosis I (PubMed:10369865, PubMed:25503965). Male germ cells show derepression of transposable elements (TEs) and DNA hypomethylation of TEs (PubMed:25503965). Mice display increased depressive-like behavior whereas no behavioral abnormalities regarding locomotor activity or anxiety-like behavior are detectable and BDNF levels in the hippocampus are up-regulated (PubMed:26275923).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002482421 – 950MORC family CW-type zinc finger protein 1Add BLAST950

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9WVL5

PeptideAtlas

More...
PeptideAtlasi
Q9WVL5

PRoteomics IDEntifications database

More...
PRIDEi
Q9WVL5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
252592

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9WVL5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WVL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at very low level in male germ cells.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in embryonic testis at embryonic days 14.5 dpc and peaks at 16.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022652, Expressed in gonadal ridge and 76 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9WVL5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000023330

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9WVL5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9WVL5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni532 – 552DisorderedSequence analysisAdd BLAST21
Regioni679 – 700DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili281 – 342Sequence analysisAdd BLAST62
Coiled coili885 – 916Sequence analysisAdd BLAST32

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri465 – 530CW-typePROSITE-ProRule annotationAdd BLAST66

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1845, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153998

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011516_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9WVL5

Identification of Orthologs from Complete Genome Data

More...
OMAi
ASSWEMK

Database of Orthologous Groups

More...
OrthoDBi
193855at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9WVL5

TreeFam database of animal gene trees

More...
TreeFami
TF329118

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036890, HATPase_C_sf
IPR041006, Morc_S5
IPR011124, Znf_CW

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17942, Morc6_S5, 1 hit
PF07496, zf-CW, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55874, SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51050, ZF_CW, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9WVL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKYALLQRA KLHLDFIHAN STTHSFLFGA LAELLDNARD AGAVRLDVFS
60 70 80 90 100
VDNETLQGGF MLCFLDDGCG MSPDEASDVI YFGTSKKRLS TLKFIGQYGN
110 120 130 140 150
GLKSGSMRIG KDCILFTKKE ETMTCLFFSQ TFCEKEGLTE VVVPIPSWLT
160 170 180 190 200
RTRESITDDP QKFFTELSII FKYSPFKTEA ELMQQFDMIY GRCGTLLIIY
210 220 230 240 250
NLKLLLSGEP ELDVTTDKED ILMAEAPEEI PERRSFRAYT AVLYFEPRMK
260 270 280 290 300
IFIQAKRVQT KHLCYSLYKP RKYQYTTSSF KGKFKTEVQK AEEAVKRAEL
310 320 330 340 350
LFKEVQAKVN QPDRIALSST QDALQKALQD VDTKHKSLRQ KQRALRKART
360 370 380 390 400
LSLFFGVNTE DQHQAGMFIY SNNRLIKMYE KVGPQLKMKS LLGAGIIGIV
410 420 430 440 450
NIPLETMEPS HNKQEFLNVQ EYNHLLKVMG QYLIQYCKDI GISNRNLTLF
460 470 480 490 500
WDEFKYQHSK DTDSSLESLQ WRRRQAMGIP FILQCDLCLK WRVLPSSSNY
510 520 530 540 550
QEKGLPDLWI CASNPNNLEN SCNQIERLPS IPLGTVNRRP PSKDERERQL
560 570 580 590 600
QESVQRYQDK LVEAQPQKSQ LIVTSKIPEF KSSCLSSALK EKSKLGRIQP
610 620 630 640 650
SGADLTQGSP SSVKLSFMQR SQKRSTEDTH SDVEFICMTK IPKKSVKKTV
660 670 680 690 700
KYLQPGHAPA LLENLKLEDT AQVSSREIKK QQSESLVQAG KASTDVASSR
710 720 730 740 750
DPTVTMVWDQ SSTKVSLKQE EEEEVPLIKP DKQELCDDTP VVKGNSSALH
760 770 780 790 800
WKSLPGVQME DLSPRSGHKI NSVSGDCQLP ASPMPSQSMS VEETARKLLS
810 820 830 840 850
NLREILLYFV PEFQLSSEFE CTSVEELITN PELERCPENI NEKLKTCFNQ
860 870 880 890 900
IQNIYMAQYE KRLKRKMQSI VYEANRRGLL NQVFLGQCEL KRKRTEEKLS
910 920 930 940 950
DLRAKLALLL QKLQLGGPAG DPQQIDAYLE DLLKEDRLPT ALHEKSPESA
Length:950
Mass (Da):108,310
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DE2D3D30DB18F43
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF084945 mRNA Translation: AAD43003.1
BC030893 mRNA Translation: AAH30893.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37351.1

NCBI Reference Sequences

More...
RefSeqi
NP_034946.1, NM_010816.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000023330; ENSMUSP00000023330; ENSMUSG00000022652

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17450

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17450

UCSC genome browser

More...
UCSCi
uc007zjp.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084945 mRNA Translation: AAD43003.1
BC030893 mRNA Translation: AAH30893.1
CCDSiCCDS37351.1
RefSeqiNP_034946.1, NM_010816.1

3D structure databases

SMRiQ9WVL5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023330

PTM databases

iPTMnetiQ9WVL5
PhosphoSitePlusiQ9WVL5

Proteomic databases

PaxDbiQ9WVL5
PeptideAtlasiQ9WVL5
PRIDEiQ9WVL5
ProteomicsDBi252592

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32406, 124 antibodies

The DNASU plasmid repository

More...
DNASUi
17450

Genome annotation databases

EnsembliENSMUST00000023330; ENSMUSP00000023330; ENSMUSG00000022652
GeneIDi17450
KEGGimmu:17450
UCSCiuc007zjp.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27136
MGIiMGI:1316740, Morc1
VEuPathDBiHostDB:ENSMUSG00000022652

Phylogenomic databases

eggNOGiKOG1845, Eukaryota
GeneTreeiENSGT00940000153998
HOGENOMiCLU_011516_0_1_1
InParanoidiQ9WVL5
OMAiASSWEMK
OrthoDBi193855at2759
PhylomeDBiQ9WVL5
TreeFamiTF329118

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
17450, 1 hit in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Morc1, mouse

Protein Ontology

More...
PROi
PR:Q9WVL5
RNActiQ9WVL5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022652, Expressed in gonadal ridge and 76 other tissues
GenevisibleiQ9WVL5, MM

Family and domain databases

Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR036890, HATPase_C_sf
IPR041006, Morc_S5
IPR011124, Znf_CW
PfamiView protein in Pfam
PF17942, Morc6_S5, 1 hit
PF07496, zf-CW, 1 hit
SUPFAMiSSF55874, SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS51050, ZF_CW, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMORC1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WVL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1999
Last modified: September 29, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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