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Protein

Type-1 angiotensin II receptor-associated protein

Gene

Agtrap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway.2 Publications

GO - Molecular functioni

  • angiotensin type II receptor activity Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene namesi
Name:Agtrap
Synonyms:Atrap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1339977 Agtrap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 53CytoplasmicSequence analysis6
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 86ExtracellularSequence analysisAdd BLAST12
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 161CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647361 – 161Type-1 angiotensin II receptor-associated proteinAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphoserineBy similarity1
Modified residuei135PhosphothreonineBy similarity1
Modified residuei138PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9WVK0
PaxDbiQ9WVK0
PeptideAtlasiQ9WVK0
PRIDEiQ9WVK0

PTM databases

iPTMnetiQ9WVK0
PhosphoSitePlusiQ9WVK0

Expressioni

Tissue specificityi

Ubiquitous but more abundant in kidney, testis and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000029007 Expressed in 236 organ(s), highest expression level in embryonic stem cell
GenevisibleiQ9WVK0 MM

Interactioni

Subunit structurei

Interacts with RACK1 (By similarity), and with the C-terminal region of AGTR1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Agtr1aP297545EBI-645964,EBI-765178

Protein-protein interaction databases

BioGridi198032, 2 interactors
IntActiQ9WVK0, 2 interactors
MINTiQ9WVK0
STRINGi10090.ENSMUSP00000030865

Structurei

3D structure databases

ProteinModelPortaliQ9WVK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 122Interaction with AGTR1By similarityAdd BLAST13

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYP8 Eukaryota
ENOG4111P37 LUCA
GeneTreeiENSGT00390000017402
HOGENOMiHOG000034218
HOVERGENiHBG080881
InParanoidiQ9WVK0
OMAiYHMYRER
OrthoDBiEOG091G0TSZ
TreeFamiTF324477

Family and domain databases

InterProiView protein in InterPro
IPR009436 AGTRAP
PANTHERiPTHR16521 PTHR16521, 1 hit
PfamiView protein in Pfam
PF06396 AGTRAP, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD357679 PD357679, 1 hit
SMARTiView protein in SMART
SM00805 AGTRAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WVK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELPAVNLKV ILLVHWLLTT WGCLVFSSSY AWGNFTILAL GVWAVAQRDS
60 70 80 90 100
IDAIGMFLGG LVATIFLDII YISIFYSSVA TGDTGRFGAG MAILSLLLKP
110 120 130 140 150
FSCCLVYHMH RERGGELPLR PDFFGPSQEH SAYQTIDSSS DAAADPFASL
160
ENKGQAVPRG Y
Length:161
Mass (Da):17,525
Last modified:October 3, 2012 - v2
Checksum:i42094CBD40A2F97C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35F → L in BAB25074 (PubMed:16141072).Curated1
Sequence conflicti157V → A in AAD25997 (PubMed:10358057).Curated1
Sequence conflicti157V → A in CAQ51920 (PubMed:19468303).Curated1
Sequence conflicti157V → A in AAH57196 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102548 mRNA Translation: AAD25997.1
AK007383 mRNA Translation: BAB25001.1
AK007502 mRNA Translation: BAB25074.1
AK036598 mRNA Translation: BAC29501.1
AK152467 mRNA Translation: BAE31243.1
CU207376 Genomic DNA Translation: CAQ51920.1
AL606929 Genomic DNA Translation: CAM14899.1
CH466594 Genomic DNA Translation: EDL14800.1
BC046820 mRNA Translation: AAH46820.1
BC057196 mRNA Translation: AAH57196.1
CCDSiCCDS18930.1
RefSeqiNP_033772.2, NM_009642.5
UniGeneiMm.46247

Genome annotation databases

EnsembliENSMUST00000030865; ENSMUSP00000030865; ENSMUSG00000029007
GeneIDi11610
KEGGimmu:11610
UCSCiuc008vtz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102548 mRNA Translation: AAD25997.1
AK007383 mRNA Translation: BAB25001.1
AK007502 mRNA Translation: BAB25074.1
AK036598 mRNA Translation: BAC29501.1
AK152467 mRNA Translation: BAE31243.1
CU207376 Genomic DNA Translation: CAQ51920.1
AL606929 Genomic DNA Translation: CAM14899.1
CH466594 Genomic DNA Translation: EDL14800.1
BC046820 mRNA Translation: AAH46820.1
BC057196 mRNA Translation: AAH57196.1
CCDSiCCDS18930.1
RefSeqiNP_033772.2, NM_009642.5
UniGeneiMm.46247

3D structure databases

ProteinModelPortaliQ9WVK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198032, 2 interactors
IntActiQ9WVK0, 2 interactors
MINTiQ9WVK0
STRINGi10090.ENSMUSP00000030865

PTM databases

iPTMnetiQ9WVK0
PhosphoSitePlusiQ9WVK0

Proteomic databases

MaxQBiQ9WVK0
PaxDbiQ9WVK0
PeptideAtlasiQ9WVK0
PRIDEiQ9WVK0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030865; ENSMUSP00000030865; ENSMUSG00000029007
GeneIDi11610
KEGGimmu:11610
UCSCiuc008vtz.1 mouse

Organism-specific databases

CTDi57085
MGIiMGI:1339977 Agtrap

Phylogenomic databases

eggNOGiENOG410IYP8 Eukaryota
ENOG4111P37 LUCA
GeneTreeiENSGT00390000017402
HOGENOMiHOG000034218
HOVERGENiHBG080881
InParanoidiQ9WVK0
OMAiYHMYRER
OrthoDBiEOG091G0TSZ
TreeFamiTF324477

Miscellaneous databases

PROiPR:Q9WVK0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029007 Expressed in 236 organ(s), highest expression level in embryonic stem cell
GenevisibleiQ9WVK0 MM

Family and domain databases

InterProiView protein in InterPro
IPR009436 AGTRAP
PANTHERiPTHR16521 PTHR16521, 1 hit
PfamiView protein in Pfam
PF06396 AGTRAP, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD357679 PD357679, 1 hit
SMARTiView protein in SMART
SM00805 AGTRAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATRAP_MOUSE
AccessioniPrimary (citable) accession number: Q9WVK0
Secondary accession number(s): B2KFL8
, Q3U7X6, Q9D8Z8, Q9D940
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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