UniProtKB - Q9WVJ9 (FBLN4_MOUSE)

BLAST

>sp|Q9WVJ9|FBLN4_MOUSE EGF-containing fibulin-like extracellular matrix protein 2 OS=Mus musculus OX=10090 GN=Efemp2 PE=1 SV=1
MLPFASCLPGSLLLWAFLLLLLGAASPQDPEEPDSYTECTDGYEWDADSQHCRDVNECLT
IPEACKGEMKCINHYGGYLCLPRSAAVISDLHGEGPPPPAAHAQQPNPCPQGYEPDEQES
CVDVDECTQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNL
PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCNQGYELHRDGFS
CSDIDECGYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECETGAHQCSEAQTC
VNFHGGYRCVDTNRCVEPYVQVSDNRCLCPASNPLCREQPSSIVHRYMSITSERSVPADV
FQIQATSVYPGAYNAFQIRSGNTQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM
NSLMSYRASSVLRLTVFVGAYTF

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History
Entry version 158 (07 Nov 2018)
Sequence version 1 (01 Nov 1999)
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Protein

EGF-containing fibulin-like extracellular matrix protein 2

Gene

Efemp2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
extracellular matrix constituent conferring elasticity
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 22159717

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

elastic fiber assembly Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium

Ligand

Calcium

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2129379 Molecules associated with elastic fibres

Reactomeⁱ

R-MMU-2129379 Molecules associated with elastic fibres

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: EGF-containing fibulin-like extracellular matrix protein 2 Alternative name(s): Fibulin-4 Short name: FIBL-4 Mutant p53-binding protein 1
Gene namesⁱ	Name:Efemp2 Synonyms:Fbln4, Mbp1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:1891209 Efemp2

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_0000007576	26 – 443	EGF-containing fibulin-like extracellular matrix protein 2Add BLAST		418

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	58 ↔ 121	PROSITE-ProRule annotation
Disulfide bondⁱ	65 ↔ 80	PROSITE-ProRule annotation
Disulfide bondⁱ	71 ↔ 109	PROSITE-ProRule annotation
Disulfide bondⁱ	127 ↔ 140	PROSITE-ProRule annotation
Disulfide bondⁱ	134 ↔ 149	PROSITE-ProRule annotation
Disulfide bondⁱ	151 ↔ 162	PROSITE-ProRule annotation
Disulfide bondⁱ	168 ↔ 177	PROSITE-ProRule annotation
Disulfide bondⁱ	173 ↔ 186	PROSITE-ProRule annotation
Disulfide bondⁱ	188 ↔ 201	PROSITE-ProRule annotation
Glycosylationⁱ	198	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	207 ↔ 217	PROSITE-ProRule annotation
Disulfide bondⁱ	213 ↔ 226	PROSITE-ProRule annotation
Disulfide bondⁱ	228 ↔ 241	PROSITE-ProRule annotation
Disulfide bondⁱ	247 ↔ 258	PROSITE-ProRule annotation
Disulfide bondⁱ	254 ↔ 267	PROSITE-ProRule annotation
Disulfide bondⁱ	269 ↔ 281	PROSITE-ProRule annotation
Disulfide bondⁱ	287 ↔ 300	PROSITE-ProRule annotation
Disulfide bondⁱ	294 ↔ 309	PROSITE-ProRule annotation
Disulfide bondⁱ	315 ↔ 327	PROSITE-ProRule annotation
Glycosylationⁱ	394	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9WVJ9
PaxDbⁱ	Q9WVJ9
PRIDEⁱ	Q9WVJ9

PTM databases

PhosphoSitePlusⁱ	Q9WVJ9

PhosphoSitePlusⁱ

Q9WVJ9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000024909 Expressed in 233 organ(s), highest expression level in humerus cartilage element
ExpressionAtlasⁱ	Q9WVJ9 baseline and differential
Genevisibleⁱ	Q9WVJ9 MM

Interactionⁱ

Subunit structureⁱ

Binds preferentially to p53 mutants (PubMed:10380882). Interacts with FBN1 (via N-terminal domain) (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActⁱ	Q9WVJ9, 1 interactor
STRINGⁱ	10090.ENSMUSP00000064719

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9WVJ9
SMRⁱ	Q9WVJ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	36 – 81	EGF-like 1; atypicalPROSITE-ProRule annotationAdd BLAST	46
Domainⁱ	123 – 163	EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	164 – 202	EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST	39
Domainⁱ	203 – 242	EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	243 – 282	EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	283 – 328	EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST	46

Sequence similaritiesⁱ

Belongs to the fibulin family.Curated

Keywords - Domainⁱ

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IR6U Eukaryota ENOG410ZNNG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118806
HOGENOMⁱ	HOG000234337
HOVERGENⁱ	HBG051560
InParanoidⁱ	Q9WVJ9
KEGG Orthology (KO) More...KOⁱ	K19866
OMAⁱ	QECHNLP
PhylomeDBⁱ	Q9WVJ9

Family and domain databases

InterProⁱ	View protein in InterPro IPR026823 cEGF IPR026824 Efemp2 IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR037287 Fibulin_3/4/5 IPR009030 Growth_fac_rcpt_cys_sf
PANTHERⁱ	PTHR44074 PTHR44074, 1 hit PTHR44074:SF3 PTHR44074:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12662 cEGF, 2 hits PF07645 EGF_CA, 3 hits
SMARTⁱ	View protein in SMART SM00181 EGF, 5 hits SM00179 EGF_CA, 6 hits
SUPFAMⁱ	SSF57184 SSF57184, 3 hits
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 4 hits PS01186 EGF_2, 4 hits PS50026 EGF_3, 4 hits PS01187 EGF_CA, 6 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show all Align All

Q9WVJ9-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MLPFASCLPG SLLLWAFLLL LLGAASPQDP EEPDSYTECT DGYEWDADSQ 
        60         70         80         90        100
HCRDVNECLT IPEACKGEMK CINHYGGYLC LPRSAAVISD LHGEGPPPPA 
       110        120        130        140        150
AHAQQPNPCP QGYEPDEQES CVDVDECTQA LHDCRPSQDC HNLPGSYQCT 
       160        170        180        190        200
CPDGYRKIGP ECVDIDECRY RYCQHRCVNL PGSFRCQCEP GFQLGPNNRS 
       210        220        230        240        250
CVDVNECDMG APCEQRCFNS YGTFLCRCNQ GYELHRDGFS CSDIDECGYS 
       260        270        280        290        300
SYLCQYRCVN EPGRFSCHCP QGYQLLATRL CQDIDECETG AHQCSEAQTC 
       310        320        330        340        350
VNFHGGYRCV DTNRCVEPYV QVSDNRCLCP ASNPLCREQP SSIVHRYMSI 
       360        370        380        390        400
TSERSVPADV FQIQATSVYP GAYNAFQIRS GNTQGDFYIR QINNVSAMLV 
       410        420        430        440 
LARPVTGPRE YVLDLEMVTM NSLMSYRASS VLRLTVFVGA YTF

Length:443

Mass (Da):49,425

Last modified:November 1, 1999 - v1

Checksum:ⁱ4969C0328A23DD88

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	G5E8D6	G5E8D6_MOUSE	EGF-containing fibulin-like extrace... EGF-containing fibulin-like extracellular matrix protein 2 (Epidermal growth factor-containing fibulin-like extracellular matrix protein 2, isoform CRA_c)	Efemp2 mCG_11764	462	Annotation score:
	E9Q3N9	E9Q3N9_MOUSE	EGF-containing fibulin-like extrace... EGF-containing fibulin-like extracellular matrix protein 2	Efemp2	402	Annotation score:
	E9Q3F3	E9Q3F3_MOUSE	EGF-containing fibulin-like extrace... EGF-containing fibulin-like extracellular matrix protein 2	Efemp2	280	Annotation score:
	E9Q2T8	E9Q2T8_MOUSE	EGF-containing fibulin-like extrace... EGF-containing fibulin-like extracellular matrix protein 2	Efemp2	191	Annotation score:
	E9Q1U0	E9Q1U0_MOUSE	EGF-containing fibulin-like extrace... EGF-containing fibulin-like extracellular matrix protein 2	Efemp2	128	Annotation score:
	E9Q2A0	E9Q2A0_MOUSE	EGF-containing fibulin-like extrace... EGF-containing fibulin-like extracellular matrix protein 2	Efemp2	153	Annotation score:
	E9PYW6	E9PYW6_MOUSE	EGF-containing fibulin-like extrace... EGF-containing fibulin-like extracellular matrix protein 2	Efemp2	82	Annotation score:
	E9Q8E0	E9Q8E0_MOUSE	EGF-containing fibulin-like extrace... EGF-containing fibulin-like extracellular matrix protein 2	Efemp2	66	Annotation score:
	F6Z1C2	F6Z1C2_MOUSE	EGF-containing fibulin-like extrace... EGF-containing fibulin-like extracellular matrix protein 2	Efemp2	157	Annotation score:
	F7AYH6	F7AYH6_MOUSE	EGF-containing fibulin-like extrace... EGF-containing fibulin-like extracellular matrix protein 2	Efemp2	120	Annotation score:
There is more potential isoformShow all

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF104223 mRNA Translation: AAD45219.1 BC012269 mRNA Translation: AAH12269.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29466.1
NCBI Reference Sequences More...RefSeqⁱ	NP_067449.3, NM_021474.3 XP_006531871.1, XM_006531808.1
UniGeneⁱ	Mm.276367

Genome annotation databases

Ensemblⁱ	ENSMUST00000165485; ENSMUSP00000133016; ENSMUSG00000024909
GeneIDⁱ	58859
KEGGⁱ	mmu:58859
UCSC genome browser More...UCSCⁱ	uc008gdl.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9WVJ9	EGF-containing fibulin-like extracellular matrix protein 2		MOUSE		462	UniRef100_Q9WVJ9
Epidermal growth factor-containing fibulin-like extracellular matrix protein 2, isoform CRA_a		MOUSE		443
EGF-containing fibulin-like extracellular matrix protein 2 (Fragment)		MOUSE		191
EGF-containing fibulin-like extracellular matrix protein 2 (Fragment)		MOUSE		128
EGF-containing fibulin-like extracellular matrix protein 2 (Fragment)		MOUSE		153
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9WVJ9	EGF-containing fibulin-like extracellular matrix protein 2		MOUSE		462	UniRef90_Q9WVJ9
EGF-containing fibulin-like extracellular matrix protein 2 isoform X2		DELLE		514
EGF containing fibulin extracellular matrix protein 2		CALJA		465
Uncharacterized protein		PIG		462
EGF-containing fibulin-like extracellular matrix protein 2 isoform X1		MESAU		462
+60

Protein	Similar proteins		Species	Score	Length	Source
Q9WVJ9	EGF-containing fibulin-like extracellular matrix protein 2		MOUSE		462	UniRef50_Q9WVJ9
EGF-containing fibulin-like extracellular matrix protein 2 isoform X2		DELLE		514
EGF containing fibulin extracellular matrix protein 2		CALJA		465
Uncharacterized protein		PIG		462
EGF-containing fibulin-like extracellular matrix protein 2 isoform X1		MESAU		462
+63

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF104223 mRNA Translation: AAD45219.1 BC012269 mRNA Translation: AAH12269.1
CCDSⁱ	CCDS29466.1
RefSeqⁱ	NP_067449.3, NM_021474.3 XP_006531871.1, XM_006531808.1
UniGeneⁱ	Mm.276367

3D structure databases

ProteinModelPortalⁱ	Q9WVJ9
SMRⁱ	Q9WVJ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9WVJ9, 1 interactor
STRINGⁱ	10090.ENSMUSP00000064719

PTM databases

PhosphoSitePlusⁱ	Q9WVJ9

PhosphoSitePlusⁱ

Q9WVJ9

Proteomic databases

MaxQBⁱ	Q9WVJ9
PaxDbⁱ	Q9WVJ9
PRIDEⁱ	Q9WVJ9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000165485; ENSMUSP00000133016; ENSMUSG00000024909
GeneIDⁱ	58859
KEGGⁱ	mmu:58859
UCSCⁱ	uc008gdl.2 mouse

Organism-specific databases

CTDⁱ	30008
MGIⁱ	MGI:1891209 Efemp2

Phylogenomic databases

eggNOGⁱ	ENOG410IR6U Eukaryota ENOG410ZNNG LUCA
GeneTreeⁱ	ENSGT00760000118806
HOGENOMⁱ	HOG000234337
HOVERGENⁱ	HBG051560
InParanoidⁱ	Q9WVJ9
KOⁱ	K19866
OMAⁱ	QECHNLP
PhylomeDBⁱ	Q9WVJ9

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2129379 Molecules associated with elastic fibres

Reactomeⁱ

R-MMU-2129379 Molecules associated with elastic fibres

Miscellaneous databases

ChiTaRSⁱ	Efemp2 mouse
Protein Ontology More...PROⁱ	PR:Q9WVJ9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024909 Expressed in 233 organ(s), highest expression level in humerus cartilage element
ExpressionAtlasⁱ	Q9WVJ9 baseline and differential
Genevisibleⁱ	Q9WVJ9 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR026823 cEGF IPR026824 Efemp2 IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR037287 Fibulin_3/4/5 IPR009030 Growth_fac_rcpt_cys_sf
PANTHERⁱ	PTHR44074 PTHR44074, 1 hit PTHR44074:SF3 PTHR44074:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF12662 cEGF, 2 hits PF07645 EGF_CA, 3 hits
SMARTⁱ	View protein in SMART SM00181 EGF, 5 hits SM00179 EGF_CA, 6 hits
SUPFAMⁱ	SSF57184 SSF57184, 3 hits
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 4 hits PS01186 EGF_2, 4 hits PS50026 EGF_3, 4 hits PS01187 EGF_CA, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FBLN4_MOUSE
Accessionⁱ	Q9WVJ9Primary (citable) accession number: Q9WVJ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9WVJ9 (FBLN4_MOUSE)

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EGF-containing fibulin-like extracellular matrix protein 2

Efemp2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ