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Protein

Carboxypeptidase Q

Gene

Cpq

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi288Zinc 1By similarity1
Metal bindingi300Zinc 1By similarity1
Metal bindingi300Zinc 2; catalyticBy similarity1
Active sitei334NucleophileBy similarity1
Metal bindingi335Zinc 2; catalyticBy similarity1
Metal bindingi362Zinc 1By similarity1
Metal bindingi432Zinc 2; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM28.014

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Q (EC:3.4.17.-)
Alternative name(s):
Hematopoietic lineage switch 2
Plasma glutamate carboxypeptidase
Gene namesi
Name:Cpq
Synonyms:Hls2, Pgcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1889205 Cpq

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000031226019 – 42By similarityAdd BLAST24
ChainiPRO_000031226143 – 470Carboxypeptidase QAdd BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains.By similarity

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9WVJ3
PeptideAtlasiQ9WVJ3
PRIDEiQ9WVJ3

PTM databases

PhosphoSitePlusiQ9WVJ3

Expressioni

Gene expression databases

BgeeiENSMUSG00000039007 Expressed in 251 organ(s), highest expression level in epithelium of lens
CleanExiMM_PGCP
GenevisibleiQ9WVJ3 MM

Interactioni

Subunit structurei

Homodimer. The monomeric form is inactive while the homodimer is active (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039046

Structurei

3D structure databases

ProteinModelPortaliQ9WVJ3
SMRiQ9WVJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M28 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2195 Eukaryota
COG2234 LUCA
GeneTreeiENSGT00390000018110
HOGENOMiHOG000295607
HOVERGENiHBG105014
InParanoidiQ9WVJ3
KOiK01302
OMAiFMNEENG
OrthoDBiEOG091G08CB
PhylomeDBiQ9WVJ3
TreeFamiTF323248

Family and domain databases

InterProiView protein in InterPro
IPR007484 Peptidase_M28
PfamiView protein in Pfam
PF04389 Peptidase_M28, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9WVJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSLFFLFIV HLLALGSGKA VFKNGVSQRT FREIKEEIAN YEDVAKAIIN
60 70 80 90 100
LAVYGKYQNR SYERLGLLVD TVGPRLSGSK NLEKAIQIMY QNLQQDGLEN
110 120 130 140 150
VHLEQVRIPH WERGEESAVM LEPRIHKMAI LGLGSSIGTP PGGITAEVLV
160 170 180 190 200
VASFDELQRR ASEARGKIIV YNQPYTGYEK TVQYRVQGAV EAAKVGAVAS
210 220 230 240 250
LIQSVASFSI YSPHTGIQKY QDGVPKIPTA CITVEDAEMM SRMASRGNKI
260 270 280 290 300
VIHLEMGAKT YPDTDSFNTV AEITGSMYPE EVVLVSGHLD SWDVGQGALD
310 320 330 340 350
DGGGAFISWE ALSLVKDLGL RPKRTLRLVL WTAEEQGGIG ASQYYELHKA
360 370 380 390 400
NISKYSLVME ADSGTFLPTG LQFTGSDKAR AIMKEVMNLL QPLNVTKVFS
410 420 430 440 450
NGEGTDINFW IQAGVPGASL RDDLYKYFFF HHSHGDTMTV MDPKQMNVAA
460 470
AVWAVVAYVV ADMDEMLPRS
Length:470
Mass (Da):51,813
Last modified:November 1, 1999 - v1
Checksum:i0F3490681691866A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BS14A0A2I3BS14_MOUSE
Carboxypeptidase Q
Cpq
198Annotation score:
A0A2I3BPG0A0A2I3BPG0_MOUSE
Carboxypeptidase Q
Cpq
115Annotation score:

Sequence cautioni

The sequence AAC17945 differs from that shown. Aberrant splicing.Curated
The sequence AAC17945 differs from that shown. Reason: Frameshift at position 440.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167K → E in BAE30978 (PubMed:16141072).Curated1
Sequence conflicti281 – 292Missing in AAC17945 (Ref. 1) CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009513 mRNA Translation: AAC17945.1 Sequence problems.
AF107835 mRNA Translation: AAD43215.1
AK032972 mRNA Translation: BAC28105.1
AK075686 mRNA Translation: BAC35891.1
AK135096 mRNA Translation: BAE22419.1
AK137164 mRNA Translation: BAE23259.1
AK152139 mRNA Translation: BAE30978.1
AK152145 mRNA Translation: BAE30982.1
BC037067 mRNA Translation: AAH37067.1
CCDSiCCDS27414.1
RefSeqiNP_061225.2, NM_018755.2
NP_788262.1, NM_176073.4
UniGeneiMm.158251

Genome annotation databases

EnsembliENSMUST00000042167; ENSMUSP00000039046; ENSMUSG00000039007
ENSMUST00000228916; ENSMUSP00000154400; ENSMUSG00000039007
GeneIDi54381
KEGGimmu:54381
UCSCiuc007vla.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009513 mRNA Translation: AAC17945.1 Sequence problems.
AF107835 mRNA Translation: AAD43215.1
AK032972 mRNA Translation: BAC28105.1
AK075686 mRNA Translation: BAC35891.1
AK135096 mRNA Translation: BAE22419.1
AK137164 mRNA Translation: BAE23259.1
AK152139 mRNA Translation: BAE30978.1
AK152145 mRNA Translation: BAE30982.1
BC037067 mRNA Translation: AAH37067.1
CCDSiCCDS27414.1
RefSeqiNP_061225.2, NM_018755.2
NP_788262.1, NM_176073.4
UniGeneiMm.158251

3D structure databases

ProteinModelPortaliQ9WVJ3
SMRiQ9WVJ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039046

Protein family/group databases

MEROPSiM28.014

PTM databases

PhosphoSitePlusiQ9WVJ3

Proteomic databases

PaxDbiQ9WVJ3
PeptideAtlasiQ9WVJ3
PRIDEiQ9WVJ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042167; ENSMUSP00000039046; ENSMUSG00000039007
ENSMUST00000228916; ENSMUSP00000154400; ENSMUSG00000039007
GeneIDi54381
KEGGimmu:54381
UCSCiuc007vla.1 mouse

Organism-specific databases

CTDi10404
MGIiMGI:1889205 Cpq

Phylogenomic databases

eggNOGiKOG2195 Eukaryota
COG2234 LUCA
GeneTreeiENSGT00390000018110
HOGENOMiHOG000295607
HOVERGENiHBG105014
InParanoidiQ9WVJ3
KOiK01302
OMAiFMNEENG
OrthoDBiEOG091G08CB
PhylomeDBiQ9WVJ3
TreeFamiTF323248

Miscellaneous databases

ChiTaRSiCpq mouse
PROiPR:Q9WVJ3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039007 Expressed in 251 organ(s), highest expression level in epithelium of lens
CleanExiMM_PGCP
GenevisibleiQ9WVJ3 MM

Family and domain databases

InterProiView protein in InterPro
IPR007484 Peptidase_M28
PfamiView protein in Pfam
PF04389 Peptidase_M28, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCBPQ_MOUSE
AccessioniPrimary (citable) accession number: Q9WVJ3
Secondary accession number(s): O70216, Q3U8N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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