UniProtKB - Q9WVJ2 (PSD13_MOUSE)
Protein
26S proteasome non-ATPase regulatory subunit 13
Gene
Psmd13
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.By similarity
GO - Molecular functioni
- endopeptidase activity Source: MGI
- structural molecule activity Source: GO_Central
GO - Biological processi
- meiosis I Source: MGI
- proteasome assembly Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: GO_Central
Enzyme and pathway databases
Reactomei | R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253, Degradation of beta-catenin by the destruction complex R-MMU-202424, Downstream TCR signaling R-MMU-2467813, Separation of Sister Chromatids R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-MMU-350562, Regulation of ornithine decarboxylase (ODC) R-MMU-382556, ABC-family proteins mediated transport R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641257, Degradation of AXIN R-MMU-4641258, Degradation of DVL R-MMU-5358346, Hedgehog ligand biogenesis R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5610780, Degradation of GLI1 by the proteasome R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome R-MMU-5632684, Hedgehog 'on' state R-MMU-5658442, Regulation of RAS by GAPs R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-5689603, UCH proteinases R-MMU-5689880, Ub-specific processing proteases R-MMU-6798695, Neutrophil degranulation R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex R-MMU-68949, Orc1 removal from chromatin R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69481, G2/M Checkpoints R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-MMU-8939902, Regulation of RUNX2 expression and activity R-MMU-8941858, Regulation of RUNX3 expression and activity R-MMU-8948751, Regulation of PTEN stability and activity R-MMU-8951664, Neddylation R-MMU-9020702, Interleukin-1 signaling R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome non-ATPase regulatory subunit 13Alternative name(s): 26S proteasome regulatory subunit RPN9 26S proteasome regulatory subunit S11 26S proteasome regulatory subunit p40.5 |
Gene namesi | Name:Psmd13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1345192, Psmd13 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Other locations
- proteasome accessory complex Source: UniProtKB
- proteasome complex Source: MGI
- proteasome regulatory particle Source: MGI
- proteasome regulatory particle, lid subcomplex Source: GO_Central
Keywords - Cellular componenti
ProteasomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173868 | 1 – 376 | 26S proteasome non-ATPase regulatory subunit 13Add BLAST | 376 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 298 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9WVJ2 |
jPOSTi | Q9WVJ2 |
MaxQBi | Q9WVJ2 |
PaxDbi | Q9WVJ2 |
PRIDEi | Q9WVJ2 |
PTM databases
iPTMneti | Q9WVJ2 |
PhosphoSitePlusi | Q9WVJ2 |
SwissPalmi | Q9WVJ2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025487, Expressed in adult mammalian kidney and 307 other tissues |
Genevisiblei | Q9WVJ2, MM |
Interactioni
Subunit structurei
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 204846, 51 interactors |
IntActi | Q9WVJ2, 5 interactors |
MINTi | Q9WVJ2 |
STRINGi | 10090.ENSMUSP00000026560 |
Miscellaneous databases
RNActi | Q9WVJ2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 171 – 338 | PCIPROSITE-ProRule annotationAdd BLAST | 168 |
Sequence similaritiesi
Belongs to the proteasome subunit S11 family.Curated
Phylogenomic databases
eggNOGi | KOG2908, Eukaryota |
GeneTreei | ENSGT00390000001802 |
InParanoidi | Q9WVJ2 |
OMAi | AEYAPYY |
OrthoDBi | 919955at2759 |
PhylomeDBi | Q9WVJ2 |
TreeFami | TF105612 |
Family and domain databases
InterProi | View protein in InterPro IPR000717, PCI_dom IPR035298, PSMD13 IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10539, PTHR10539, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9WVJ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDVPAFLQQ SQSSGPGQAA VWHRLEELYT KKLWHQLTLE VLDFVQDPCF
60 70 80 90 100
AQGDGLIKLY ENFISEFEHR VNPLSLVEII LHVVRQMTDP NVALTFLEKT
110 120 130 140 150
REKVKSSDEA VILCKTAIGA LKLNIGDLQA TKETIEDVEE MLNNLPGVTS
160 170 180 190 200
VHSRFYDLSS KYYQTIGNHA SYYKDALRFL GCVDIKDLPV SEQQERAFTL
210 220 230 240 250
GLAGLLGEGV FNFGELLMHP VLESLRDTDR QWLIDTLYAF NSGAVDRFQT
260 270 280 290 300
LKCAWGQQPD LAANEAQLLR KIQLLCLMEM TFTRPANHRQ LTFEEIAKSA
310 320 330 340 350
KITVNKVELL VMKALSVGLV RGSIDEVDKR VHMTWVQPRV LDLQQIKGMK
360 370
DRLELWCTDV KSMEMLVEHQ AQDILT
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6ZQQ3 | F6ZQQ3_MOUSE | 26S proteasome non-ATPase regulator... | Psmd13 | 206 | Annotation score: | ||
E9Q5I9 | E9Q5I9_MOUSE | 26S proteasome non-ATPase regulator... | Psmd13 | 349 | Annotation score: | ||
F6PXS6 | F6PXS6_MOUSE | 26S proteasome non-ATPase regulator... | Psmd13 | 96 | Annotation score: | ||
E9Q0U1 | E9Q0U1_MOUSE | 26S proteasome non-ATPase regulator... | Psmd13 | 241 | Annotation score: | ||
E9PY93 | E9PY93_MOUSE | 26S proteasome non-ATPase regulator... | Psmd13 | 72 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 358 | T → A in BAE37156 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF107838 mRNA Translation: AAD43443.1 AK051078 mRNA Translation: BAC34519.1 AK075936 mRNA Translation: BAC36066.1 AK081160 mRNA Translation: BAC38150.1 AK145654 mRNA Translation: BAE26568.1 AK163017 mRNA Translation: BAE37156.1 AK167169 mRNA Translation: BAE39307.1 AK171504 mRNA Translation: BAE42495.1 Sequence problems. |
CCDSi | CCDS21990.1 |
RefSeqi | NP_036005.1, NM_011875.4 |
Genome annotation databases
Ensembli | ENSMUST00000026560; ENSMUSP00000026560; ENSMUSG00000025487 |
GeneIDi | 23997 |
KEGGi | mmu:23997 |
UCSCi | uc009kim.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF107838 mRNA Translation: AAD43443.1 AK051078 mRNA Translation: BAC34519.1 AK075936 mRNA Translation: BAC36066.1 AK081160 mRNA Translation: BAC38150.1 AK145654 mRNA Translation: BAE26568.1 AK163017 mRNA Translation: BAE37156.1 AK167169 mRNA Translation: BAE39307.1 AK171504 mRNA Translation: BAE42495.1 Sequence problems. |
CCDSi | CCDS21990.1 |
RefSeqi | NP_036005.1, NM_011875.4 |
3D structure databases
SMRi | Q9WVJ2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204846, 51 interactors |
IntActi | Q9WVJ2, 5 interactors |
MINTi | Q9WVJ2 |
STRINGi | 10090.ENSMUSP00000026560 |
PTM databases
iPTMneti | Q9WVJ2 |
PhosphoSitePlusi | Q9WVJ2 |
SwissPalmi | Q9WVJ2 |
Proteomic databases
EPDi | Q9WVJ2 |
jPOSTi | Q9WVJ2 |
MaxQBi | Q9WVJ2 |
PaxDbi | Q9WVJ2 |
PRIDEi | Q9WVJ2 |
Protocols and materials databases
Antibodypediai | 22386, 167 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000026560; ENSMUSP00000026560; ENSMUSG00000025487 |
GeneIDi | 23997 |
KEGGi | mmu:23997 |
UCSCi | uc009kim.1, mouse |
Organism-specific databases
CTDi | 5719 |
MGIi | MGI:1345192, Psmd13 |
Phylogenomic databases
eggNOGi | KOG2908, Eukaryota |
GeneTreei | ENSGT00390000001802 |
InParanoidi | Q9WVJ2 |
OMAi | AEYAPYY |
OrthoDBi | 919955at2759 |
PhylomeDBi | Q9WVJ2 |
TreeFami | TF105612 |
Enzyme and pathway databases
Reactomei | R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253, Degradation of beta-catenin by the destruction complex R-MMU-202424, Downstream TCR signaling R-MMU-2467813, Separation of Sister Chromatids R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-MMU-350562, Regulation of ornithine decarboxylase (ODC) R-MMU-382556, ABC-family proteins mediated transport R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641257, Degradation of AXIN R-MMU-4641258, Degradation of DVL R-MMU-5358346, Hedgehog ligand biogenesis R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5610780, Degradation of GLI1 by the proteasome R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome R-MMU-5632684, Hedgehog 'on' state R-MMU-5658442, Regulation of RAS by GAPs R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-5689603, UCH proteinases R-MMU-5689880, Ub-specific processing proteases R-MMU-6798695, Neutrophil degranulation R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex R-MMU-68949, Orc1 removal from chromatin R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69481, G2/M Checkpoints R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-MMU-8939902, Regulation of RUNX2 expression and activity R-MMU-8941858, Regulation of RUNX3 expression and activity R-MMU-8948751, Regulation of PTEN stability and activity R-MMU-8951664, Neddylation R-MMU-9020702, Interleukin-1 signaling R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 23997, 9 hits in 17 CRISPR screens |
ChiTaRSi | Psmd13, mouse |
PROi | PR:Q9WVJ2 |
RNActi | Q9WVJ2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025487, Expressed in adult mammalian kidney and 307 other tissues |
Genevisiblei | Q9WVJ2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000717, PCI_dom IPR035298, PSMD13 IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10539, PTHR10539, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSD13_MOUSE | |
Accessioni | Q9WVJ2Primary (citable) accession number: Q9WVJ2 Secondary accession number(s): Q3TB19, Q3TR74, Q542R0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2002 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families