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Entry version 159 (11 Dec 2019)
Sequence version 3 (20 Dec 2017)
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Protein

Potassium voltage-gated channel subfamily H member 3

Gene

Kcnh3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi593 – 708cNMPAdd BLAST116

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1296072 Voltage gated Potassium channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 3
Alternative name(s):
Ether-a-go-go-like potassium channel 2
Short name:
ELK channel 2
Short name:
mElk2
Voltage-gated potassium channel subunit Kv12.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kcnh3
Synonyms:Elk2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1341723 Kcnh3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 228CytoplasmicSequence analysisAdd BLAST228
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei229 – 249Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini250 – 259ExtracellularSequence analysis10
Transmembranei260 – 280Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini281 – 302CytoplasmicSequence analysisAdd BLAST22
Transmembranei303 – 323Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini324 – 331ExtracellularSequence analysis8
Transmembranei332 – 352Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini353 – 361CytoplasmicSequence analysis9
Transmembranei362 – 382Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini383 – 464ExtracellularSequence analysisAdd BLAST82
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei465 – 485Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini486 – 490ExtracellularSequence analysis5
Transmembranei491 – 511Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini512 – 1095CytoplasmicSequence analysisAdd BLAST584

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
576

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000540061 – 1095Potassium voltage-gated channel subfamily H member 3Add BLAST1095

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9WVJ0

PRoteomics IDEntifications database

More...
PRIDEi
Q9WVJ0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9WVJ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WVJ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, but not in other tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037579 Expressed in 104 organ(s), highest expression level in oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6U1M1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000040548

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9WVJ0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9WVJ0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 90PASPROSITE-ProRule annotationAdd BLAST73
Domaini93 – 145PACPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi476 – 481Selectivity filterBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi962 – 1069Pro-richAdd BLAST108

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0498 Eukaryota
ENOG410XPSE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161742

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230794

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9WVJ0

KEGG Orthology (KO)

More...
KOi
K04906

Identification of Orthologs from Complete Genome Data

More...
OMAi
YIGQQEI

Database of Orthologous Groups

More...
OrthoDBi
247304at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313130

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038 CAP_ED, 1 hit
cd00130 PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR003950 K_chnl_volt-dep_ELK
IPR001610 PAC
IPR000014 PAS
IPR000700 PAS-assoc_C
IPR035965 PAS-like_dom_sf
IPR014710 RmlC-like_jellyroll

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF13426 PAS_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01463 EAGCHANLFMLY
PR01465 ELKCHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00100 cNMP, 1 hit
SM00086 PAC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51206 SSF51206, 1 hit
SSF55785 SSF55785, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00229 sensory_box, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50113 PAC, 1 hit
PS50112 PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9WVJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC
60 70 80 90 100
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY
110 120 130 140 150
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDNWKERGG
160 170 180 190 200
GRRRYGRAGS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP
210 220 230 240 250
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST
260 270 280 290 300
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL
310 320 330 340 350
HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD
360 370 380 390 400
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQQEIESSE SELPEIGWLQ
410 420 430 440 450
ELARRLETPY YLVSRSPDGG NSSGQSENCS SSSSSSGSGG GRGSEANGTG
460 470 480 490 500
LELLGGPSLR SAYITSLYFA LSSLTSVGFG NVSANTDTEK IFSICTMLIG
510 520 530 540 550
ALMHAVVFGN VTAIIQRMYA RRFLYHSRTR DLRDYIRIHR IPKPLKQRML
560 570 580 590 600
EYFQATWAVN NGIDTTELLQ SLPDELRADI AMHLHKEVLQ LPLFEAASRG
610 620 630 640 650
CLRALSLALR PAFCTPGEYL IHQGDALQAL YFVCSGSMEV LKGGTVLAIL
660 670 680 690 700
GKGDLIGCEL PQREQVVKAN ADVKGLTYCV LQCLQLAGLH ESLALYPEFA
710 720 730 740 750
PRFSRGLRGE LSYNLGAGGV SAEVDTSSLS GDNTLMSTLE EKETDGEQGH
760 770 780 790 800
TVSPAPADEP SSPLLSPGCT SSSSAAKLLS PRRTAPRPRL GGRGRPSRAG
810 820 830 840 850
VLKPEAGPSA HPRSLDGLQL PPMPWNVPPD LSPRVVDGIE DGCSSDQPKF
860 870 880 890 900
SFRVGQSGPE CSSSPSPGTE SGLLTVPLGP SEARNTDTLD KLRQAVMELS
910 920 930 940 950
EQVLQMREGL QSLRQAVQLI LVPQGEGQCP RGSGEEPCPA TASGLLQPLR
960 970 980 990 1000
VDTGASSYCL QPPAGSVLSG TWPHPRPGQP PPLMAPWPWG PPASQSSPWP
1010 1020 1030 1040 1050
RATALWTSTS DSEPPGSGDL CSEPSTPASP PPSEEGARTG TPAPVSQAEA
1060 1070 1080 1090
TSTGEPPPGP GGRALPWDPH SLEMVLIGCH GPGTVQWTQE EGTGV
Length:1,095
Mass (Da):118,244
Last modified:December 20, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2C3A26090E37A50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5R → P in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti388S → N in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti433 – 442SSSSGSGGGR → GG in AAD40578 (PubMed:10191308).Curated10
Sequence conflicti472S → G in AAQ90188 (Ref. 2) Curated1
Sequence conflicti497M → T in AAQ90188 (Ref. 2) Curated1
Sequence conflicti500G → A in AAQ90188 (Ref. 2) Curated1
Sequence conflicti752V → I in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti814S → T in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti844S → G in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti848P → H in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti879G → V in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti897M → T in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti932G → V in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti936E → G in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti943S → C in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti979Q → H in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti1033S → P in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti1060P → S in AAD40578 (PubMed:10191308).Curated1
Sequence conflicti1084T → S in AAD40578 (PubMed:10191308).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF109143 mRNA Translation: AAD40578.1
AY380579 mRNA Translation: AAQ90188.1
AC161198 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04139.1
BC141013 mRNA Translation: AAI41014.1
BC145145 mRNA Translation: AAI45146.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27817.1

NCBI Reference Sequences

More...
RefSeqi
NP_034731.3, NM_010601.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000041415; ENSMUSP00000040548; ENSMUSG00000037579

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16512

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16512

UCSC genome browser

More...
UCSCi
uc011zzc.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109143 mRNA Translation: AAD40578.1
AY380579 mRNA Translation: AAQ90188.1
AC161198 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04139.1
BC141013 mRNA Translation: AAI41014.1
BC145145 mRNA Translation: AAI45146.1
CCDSiCCDS27817.1
RefSeqiNP_034731.3, NM_010601.3

3D structure databases

SMRiQ9WVJ0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040548

Chemistry databases

GuidetoPHARMACOLOGYi576

PTM databases

iPTMnetiQ9WVJ0
PhosphoSitePlusiQ9WVJ0

Proteomic databases

PaxDbiQ9WVJ0
PRIDEiQ9WVJ0

Genome annotation databases

EnsembliENSMUST00000041415; ENSMUSP00000040548; ENSMUSG00000037579
GeneIDi16512
KEGGimmu:16512
UCSCiuc011zzc.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23416
MGIiMGI:1341723 Kcnh3

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
GeneTreeiENSGT00940000161742
HOGENOMiHOG000230794
InParanoidiQ9WVJ0
KOiK04906
OMAiYIGQQEI
OrthoDBi247304at2759
TreeFamiTF313130

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Kcnh3 mouse

Protein Ontology

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PROi
PR:Q9WVJ0
RNActiQ9WVJ0 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000037579 Expressed in 104 organ(s), highest expression level in oocyte
GenevisibleiQ6U1M1 MM

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00130 PAS, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR003950 K_chnl_volt-dep_ELK
IPR001610 PAC
IPR000014 PAS
IPR000700 PAS-assoc_C
IPR035965 PAS-like_dom_sf
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF13426 PAS_9, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
PR01465 ELKCHANNEL
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00086 PAC, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
SSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50113 PAC, 1 hit
PS50112 PAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNH3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WVJ0
Secondary accession number(s): B2RU85, E9QMZ8, Q6U1M1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: December 20, 2017
Last modified: December 11, 2019
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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