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Protein

Guanylate cyclase soluble subunit alpha-2

Gene

Gucy1a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has guanylyl cyclase on binding to the beta-1 subunit.

Miscellaneous

There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

Activity regulationi

Activated by nitric oxide in the presence of magnesium or manganese ions.By similarity

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • guanylate cyclase activity Source: RGD
  • heme binding Source: InterPro
  • protein heterodimerization activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processcGMP biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase soluble subunit alpha-2 (EC:4.6.1.2)
Short name:
GCS-alpha-2
Gene namesi
Name:Gucy1a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621655 Gucy1a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000741141 – 730Guanylate cyclase soluble subunit alpha-2Add BLAST730

Proteomic databases

PaxDbiQ9WVI4
PRIDEiQ9WVI4

PTM databases

iPTMnetiQ9WVI4
PhosphoSitePlusiQ9WVI4

Expressioni

Gene expression databases

BgeeiENSRNOG00000029876 Expressed in 9 organ(s), highest expression level in brain
GenevisibleiQ9WVI4 RN

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WVI4, 5 interactors
MINTiQ9WVI4
STRINGi10116.ENSRNOP00000040361

Structurei

3D structure databases

ProteinModelPortaliQ9WVI4
SMRiQ9WVI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini519 – 646Guanylate cyclasePROSITE-ProRule annotationAdd BLAST128

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 72Ala-richAdd BLAST23
Compositional biasi64 – 72Poly-Ala9

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4171 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000118959
HOVERGENiHBG106603
InParanoidiQ9WVI4
KOiK12318
OMAiQNWPNIH
OrthoDBiEOG091G04KV
PhylomeDBiQ9WVI4

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
3.90.1520.10, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR038158 H-NOX_domain_sf
IPR011644 Heme_NO-bd
IPR011645 HNOB_dom_associated
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF07700 HNOB, 1 hit
PF07701 HNOBA, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WVI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKISSES FSSLGSDYLE TSPEEEGECP LSKLCWNGSR SPPGPPGSRA
60 70 80 90 100
AAMAATPVPA ASVAAAAAAV AAGSKRAQRR RRVNLDSLGE SISLLTAPSP
110 120 130 140 150
QTIHMTLKRT LQYYEHQVIG YRDAEKNFHN ISNRCSSADH SNKEEIEDVS
160 170 180 190 200
GILRCTANVL GLKFQEIQER FGEEFFKICF DENERVLRAV GSTLQDFFNG
210 220 230 240 250
FDALLEHIRT SFGKQATLES PSFLCKELPE GTLKLHYFHP HHTVGFAMLG
260 270 280 290 300
MIKAAGKRIY HLNVEVEQIE NEKFCSDGST PSNYSCLTFL IKECETTQIT
310 320 330 340 350
KNIPQGTSQI PTDLRISINT FCRTFPFHLM FDPNMVVLQL GEGLRKQLRC
360 370 380 390 400
DNHKVLKFED CFEIVSPKVN ATFDRVLLRL STPFVIRTKP EASGTDNEDK
410 420 430 440 450
VMEIKGQMIH VPESNAILFL GSPCVDKLDE LIGRGLHLSD IPIHDATRDV
460 470 480 490 500
ILVGEQAKAQ DGLKKRMDKL KATLEKTHQA LEEEKKKTVD LLYSIFPGDV
510 520 530 540 550
AQQLWQRQQV QARKFDDVTM LFSDIVGFTA ICAQCTPMQV ISMLNELYTR
560 570 580 590 600
FDHQCGFLDI YKVETIGDAY CVASGLHRKS LCHAKPIALM ALKMMELSEE
610 620 630 640 650
VLTPDGRPIQ MRIGIHSGSV LAGVVGVRMP RYCLFGNNVT LASKFESGSH
660 670 680 690 700
PRRINISPTT YQLLKREDSF TFIPRSREEL PDNFPKEIPG VCYFLELRTG
710 720 730
PKPPKPSLSS SRIKKVSYNI GTMFLRETSL
Length:730
Mass (Da):81,787
Last modified:March 1, 2001 - v2
Checksum:iB8D790BFF81FB8F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109963 mRNA Translation: AAD42949.2
AB096080 mRNA Translation: BAC24017.1
RefSeqiNP_076446.1, NM_023956.1
UniGeneiRn.209304

Genome annotation databases

EnsembliENSRNOT00000046058; ENSRNOP00000040361; ENSRNOG00000029876
GeneIDi66012
KEGGirno:66012
UCSCiRGD:621655 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109963 mRNA Translation: AAD42949.2
AB096080 mRNA Translation: BAC24017.1
RefSeqiNP_076446.1, NM_023956.1
UniGeneiRn.209304

3D structure databases

ProteinModelPortaliQ9WVI4
SMRiQ9WVI4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVI4, 5 interactors
MINTiQ9WVI4
STRINGi10116.ENSRNOP00000040361

PTM databases

iPTMnetiQ9WVI4
PhosphoSitePlusiQ9WVI4

Proteomic databases

PaxDbiQ9WVI4
PRIDEiQ9WVI4

Protocols and materials databases

DNASUi66012
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000046058; ENSRNOP00000040361; ENSRNOG00000029876
GeneIDi66012
KEGGirno:66012
UCSCiRGD:621655 rat

Organism-specific databases

CTDi2977
RGDi621655 Gucy1a2

Phylogenomic databases

eggNOGiKOG4171 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000118959
HOVERGENiHBG106603
InParanoidiQ9WVI4
KOiK12318
OMAiQNWPNIH
OrthoDBiEOG091G04KV
PhylomeDBiQ9WVI4

Miscellaneous databases

PROiPR:Q9WVI4

Gene expression databases

BgeeiENSRNOG00000029876 Expressed in 9 organ(s), highest expression level in brain
GenevisibleiQ9WVI4 RN

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
3.90.1520.10, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR038158 H-NOX_domain_sf
IPR011644 Heme_NO-bd
IPR011645 HNOB_dom_associated
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF07700 HNOB, 1 hit
PF07701 HNOBA, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCYA2_RAT
AccessioniPrimary (citable) accession number: Q9WVI4
Secondary accession number(s): Q54A43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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