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Protein

Fibulin-5

Gene

Fbln5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (By similarity). Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:11805835). May act as an adapter that mediates the interaction between FBN1 and ELN (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-1566948 Elastic fibre formation
R-MMU-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Recommended name:
Fibulin-5
Short name:
FIBL-5
Alternative name(s):
Developmental arteries and neural crest EGF-like protein
Short name:
Dance
Gene namesi
Name:Fbln5
Synonyms:Dance
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1346091 Fbln5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice survive to adulthood, but have a tortuous aorta with loss of compliance, severe emphisema and loose skin. They exhibit a severely disorganized elastic fiber system throughout the body.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000757824 – 448Fibulin-5Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 59PROSITE-ProRule annotation
Disulfide bondi53 ↔ 68PROSITE-ProRule annotation
Disulfide bondi131 ↔ 144PROSITE-ProRule annotation
Disulfide bondi138 ↔ 153PROSITE-ProRule annotation
Disulfide bondi155 ↔ 166PROSITE-ProRule annotation
Disulfide bondi172 ↔ 181PROSITE-ProRule annotation
Disulfide bondi177 ↔ 190PROSITE-ProRule annotation
Disulfide bondi192 ↔ 205PROSITE-ProRule annotation
Disulfide bondi211 ↔ 221PROSITE-ProRule annotation
Disulfide bondi217 ↔ 230PROSITE-ProRule annotation
Disulfide bondi232 ↔ 245PROSITE-ProRule annotation
Disulfide bondi251 ↔ 262PROSITE-ProRule annotation
Disulfide bondi258 ↔ 271PROSITE-ProRule annotation
Disulfide bondi273 ↔ 286PROSITE-ProRule annotation
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi292 ↔ 305PROSITE-ProRule annotation
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi299 ↔ 314PROSITE-ProRule annotation
Disulfide bondi320 ↔ 332PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9WVH9
PaxDbiQ9WVH9
PeptideAtlasiQ9WVH9
PRIDEiQ9WVH9

PTM databases

iPTMnetiQ9WVH9
PhosphoSitePlusiQ9WVH9

Expressioni

Gene expression databases

BgeeiENSMUSG00000021186 Expressed in 256 organ(s), highest expression level in metanephros
CleanExiMM_FBLN5
ExpressionAtlasiQ9WVH9 baseline and differential
GenevisibleiQ9WVH9 MM

Interactioni

Subunit structurei

Homodimer. Monomer, homodimerizes in presence of Ca2+. Interacts with ELN (By similarity). Interacts (via N-terminus) with the integrins ITGAV/ITGB3, ITGAV/ITGB5 and ITGA9/ITGB1 (PubMed:11805835). Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WVH9, 3 interactors
MINTiQ9WVH9
STRINGi10090.ENSMUSP00000021603

Structurei

3D structure databases

ProteinModelPortaliQ9WVH9
SMRiQ9WVH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 82EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini127 – 167EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini168 – 206EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini207 – 246EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini247 – 287EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini288 – 333EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi54 – 56Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the fibulin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR76 Eukaryota
ENOG41104WD LUCA
GeneTreeiENSGT00760000118806
HOGENOMiHOG000234337
HOVERGENiHBG051560
InParanoidiQ9WVH9
KOiK17340
OMAiDDGVHCS
OrthoDBiEOG091G04QP
PhylomeDBiQ9WVH9
TreeFamiTF317514

Family and domain databases

InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037288 Fibulin-5
IPR037287 Fibulin_3/4/5
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF4 PTHR44074:SF4, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 2 hits
PF12661 hEGF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 6 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WVH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGLKRILTV TILALWLPHP GNAQQQCTNG FDLDRQSGQC LDIDECRTIP
60 70 80 90 100
EACRGDMMCV NQNGGYLCIP RTNPVYRGPY SNPYSTSYSG PYPAAAPPVP
110 120 130 140 150
ASNYPTISRP LVCRFGYQMD EGNQCVDVDE CATDSHQCNP TQICINTEGG
160 170 180 190 200
YTCSCTDGYW LLEGQCLDID ECRYGYCQQL CANVPGSYSC TCNPGFTLND
210 220 230 240 250
DGRSCQDVNE CETENPCVQT CVNTYGSFIC RCDPGYELEE DGIHCSDMDE
260 270 280 290 300
CSFSEFLCQH ECVNQPGSYF CSCPPGYVLL DDNRSCQDIN ECEHRNHTCT
310 320 330 340 350
SLQTCYNLQG GFKCIDPISC EEPYLLIGEN RCMCPAEHTS CRDQPFTILY
360 370 380 390 400
RDMDVVSGRS VPADIFQMQA TTRYPGAYYI FQIKSGNEGR EFYMRQTGPI
410 420 430 440
SATLVMTRPI KGPRDIQLDL EMITVNTVIN FRGSSVIRLR IYVSQYPF
Length:448
Mass (Da):50,193
Last modified:November 1, 1999 - v1
Checksum:iF15CC70CCFBFDC97
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VJW9A0A1Y7VJW9_MOUSE
Fibulin-5
Fbln5
461Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112151 mRNA Translation: AAD41767.1
AK085170 mRNA Translation: BAC39381.1
AK090129 mRNA Translation: BAC41109.1
AK159471 mRNA Translation: BAE35112.1
AK159960 mRNA Translation: BAE35515.1
AK165018 mRNA Translation: BAE38002.1
BC006636 mRNA Translation: AAH06636.1
CCDSiCCDS36525.1
RefSeqiNP_035942.1, NM_011812.4
UniGeneiMm.288381
Mm.465863

Genome annotation databases

EnsembliENSMUST00000021603; ENSMUSP00000021603; ENSMUSG00000021186
GeneIDi23876
KEGGimmu:23876
UCSCiuc007otp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112151 mRNA Translation: AAD41767.1
AK085170 mRNA Translation: BAC39381.1
AK090129 mRNA Translation: BAC41109.1
AK159471 mRNA Translation: BAE35112.1
AK159960 mRNA Translation: BAE35515.1
AK165018 mRNA Translation: BAE38002.1
BC006636 mRNA Translation: AAH06636.1
CCDSiCCDS36525.1
RefSeqiNP_035942.1, NM_011812.4
UniGeneiMm.288381
Mm.465863

3D structure databases

ProteinModelPortaliQ9WVH9
SMRiQ9WVH9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVH9, 3 interactors
MINTiQ9WVH9
STRINGi10090.ENSMUSP00000021603

PTM databases

iPTMnetiQ9WVH9
PhosphoSitePlusiQ9WVH9

Proteomic databases

MaxQBiQ9WVH9
PaxDbiQ9WVH9
PeptideAtlasiQ9WVH9
PRIDEiQ9WVH9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021603; ENSMUSP00000021603; ENSMUSG00000021186
GeneIDi23876
KEGGimmu:23876
UCSCiuc007otp.2 mouse

Organism-specific databases

CTDi10516
MGIiMGI:1346091 Fbln5

Phylogenomic databases

eggNOGiENOG410IR76 Eukaryota
ENOG41104WD LUCA
GeneTreeiENSGT00760000118806
HOGENOMiHOG000234337
HOVERGENiHBG051560
InParanoidiQ9WVH9
KOiK17340
OMAiDDGVHCS
OrthoDBiEOG091G04QP
PhylomeDBiQ9WVH9
TreeFamiTF317514

Enzyme and pathway databases

ReactomeiR-MMU-1566948 Elastic fibre formation
R-MMU-2129379 Molecules associated with elastic fibres

Miscellaneous databases

ChiTaRSiFbln5 mouse
PROiPR:Q9WVH9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021186 Expressed in 256 organ(s), highest expression level in metanephros
CleanExiMM_FBLN5
ExpressionAtlasiQ9WVH9 baseline and differential
GenevisibleiQ9WVH9 MM

Family and domain databases

InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037288 Fibulin-5
IPR037287 Fibulin_3/4/5
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF4 PTHR44074:SF4, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 2 hits
PF12661 hEGF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 6 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFBLN5_MOUSE
AccessioniPrimary (citable) accession number: Q9WVH9
Secondary accession number(s): Q541Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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