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Protein

Angiopoietin-4

Gene

Angpt4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAngiogenesis

Enzyme and pathway databases

ReactomeiR-MMU-210993 Tie2 Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-4
Short name:
ANG-4
Alternative name(s):
Angiopoietin-3
Short name:
ANG-3
Gene namesi
Name:Angpt4
Synonyms:Agpt4, Ang3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1336887 Angpt4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000911722 – 509Angiopoietin-4Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi297 ↔ 326PROSITE-ProRule annotation
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi450 ↔ 463PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WVH6
PRIDEiQ9WVH6

PTM databases

iPTMnetiQ9WVH6
PhosphoSitePlusiQ9WVH6

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000027460 Expressed in 72 organ(s), highest expression level in decidua
CleanExiMM_ANG3
MM_ANGPT4
ExpressionAtlasiQ9WVH6 baseline and differential
GenevisibleiQ9WVH6 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with TEK/TIE2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WVH6, 2 interactors
MINTiQ9WVH6
STRINGi10090.ENSMUSP00000028955

Structurei

3D structure databases

ProteinModelPortaliQ9WVH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 508Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili181 – 269Sequence analysisAdd BLAST89

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150824
HOGENOMiHOG000037128
HOVERGENiHBG001644
InParanoidiQ9WVH6
KOiK05467
OMAiGIRWHYF
OrthoDBiEOG091G03M1
PhylomeDBiQ9WVH6
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR028845 Ang-4
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF31 PTHR19143:SF31, 1 hit
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCQPAMLLD GLLLLATMAA AQHRGPEAGG HRQIHQVRRG QCSYTFVVPE
60 70 80 90 100
PDICQLAPTA APEALGGSNS LQRDLPASRL HLTDWRAQRA QRAQRVSQLE
110 120 130 140 150
KILENNTQWL LKLEQSIKVN LRSHLVQAQQ DTIQNQTTTM LALGANLMNQ
160 170 180 190 200
TKAQTHKLTA VEAQVLNQTL HMKTQMLENS LSTNKLERQM LMQSRELQRL
210 220 230 240 250
QGRNRALETR LQALEAQHQA QLNSLQEKRE QLHSLLGHQT GTLANLKHNL
260 270 280 290 300
HALSSNSSSL QQQQQQLTEF VQRLVRIVAQ DQHPVSLKTP KPVFQDCAEI
310 320 330 340 350
KRSGVNTSGV YTIYETNMTK PLKVFCDMET DGGGWTLIQH REDGSVNFQR
360 370 380 390 400
TWEEYKEGFG NVAREHWLGN EAVHRLTSRT AYLLRVELHD WEGRQTSIQY
410 420 430 440 450
ENFQLGSERQ RYSLSVNDSS SSAGRKNSLA PQGTKFSTKD MDNDNCMCKC
460 470 480 490 500
AQMLSGGWWF DACGLSNLNG IYYSVHQHLH KINGIRWHYF RGPSYSLHGT

RMMLRPMGA
Length:509
Mass (Da):57,805
Last modified:November 1, 1999 - v1
Checksum:i9B5A74A20A6664F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113707 mRNA Translation: AAD21586.1
CCDSiCCDS16874.1
RefSeqiNP_033771.1, NM_009641.2
UniGeneiMm.189536

Genome annotation databases

EnsembliENSMUST00000028955; ENSMUSP00000028955; ENSMUSG00000027460
GeneIDi11602
KEGGimmu:11602
UCSCiuc008neq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113707 mRNA Translation: AAD21586.1
CCDSiCCDS16874.1
RefSeqiNP_033771.1, NM_009641.2
UniGeneiMm.189536

3D structure databases

ProteinModelPortaliQ9WVH6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WVH6, 2 interactors
MINTiQ9WVH6
STRINGi10090.ENSMUSP00000028955

PTM databases

iPTMnetiQ9WVH6
PhosphoSitePlusiQ9WVH6

Proteomic databases

PaxDbiQ9WVH6
PRIDEiQ9WVH6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028955; ENSMUSP00000028955; ENSMUSG00000027460
GeneIDi11602
KEGGimmu:11602
UCSCiuc008neq.1 mouse

Organism-specific databases

CTDi51378
MGIiMGI:1336887 Angpt4

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150824
HOGENOMiHOG000037128
HOVERGENiHBG001644
InParanoidiQ9WVH6
KOiK05467
OMAiGIRWHYF
OrthoDBiEOG091G03M1
PhylomeDBiQ9WVH6
TreeFamiTF336658

Enzyme and pathway databases

ReactomeiR-MMU-210993 Tie2 Signaling

Miscellaneous databases

PROiPR:Q9WVH6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027460 Expressed in 72 organ(s), highest expression level in decidua
CleanExiMM_ANG3
MM_ANGPT4
ExpressionAtlasiQ9WVH6 baseline and differential
GenevisibleiQ9WVH6 MM

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR028845 Ang-4
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF31 PTHR19143:SF31, 1 hit
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANGP4_MOUSE
AccessioniPrimary (citable) accession number: Q9WVH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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