Protein odd-skipped-related 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• metal ion binding Source: UniProtKB-KW
• protein kinase binding Source: MGI
• protein serine/threonine kinase activity Source: MGI
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635

GO - Biological processⁱ

• cell differentiation Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 21262216
• cell proliferation involved in kidney development Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 16790474
• cellular response to retinoic acid Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 20171952
• chondrocyte differentiation Source: BHF-UCLInferred from genetic interactionⁱ
  • 21262216
• embryonic digit morphogenesis Source: BHF-UCLInferred from genetic interactionⁱ
  • 21262216
• embryonic forelimb morphogenesis Source: BHF-UCLInferred from genetic interactionⁱ
  • 21262216
• embryonic hindlimb morphogenesis Source: BHF-UCLInferred from genetic interactionⁱ
  • 21262216
• embryonic skeletal joint development Source: BHF-UCLInferred from genetic interactionⁱ
  • 21262216
• embryonic skeletal joint morphogenesis Source: BHF-UCLInferred from genetic interactionⁱ
  • 21262216
• embryonic skeletal limb joint morphogenesis Source: BHF-UCLInferred from genetic interactionⁱ
  • 21262216
• gonad development Source: MGIInferred from mutant phenotypeⁱ
  • 16223478
• heart development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16223478
  • 16790474
• intermediate mesoderm development Source: MGIInferred from mutant phenotypeⁱ
  • 16223478
• mesangial cell development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18835385
• mesonephric duct morphogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• mesonephros development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• metanephric cap mesenchymal cell proliferation involved in metanephros development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18835385
• metanephric epithelium development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18835385
• metanephric glomerulus vasculature development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18835385
• metanephric interstitial fibroblast development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18835385
• metanephric mesenchymal cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• metanephric mesenchyme development Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 20171952
• metanephric mesenchyme morphogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• metanephric nephron tubule development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18835385
• metanephric smooth muscle tissue development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18835385
• metanephros development Source: MGIInferred from mutant phenotypeⁱ
  • 16223478
• middle ear morphogenesis Source: UniProtKBInferred from genetic interactionⁱ
  • 19389375
• negative regulation of apoptotic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• negative regulation of creatine transmembrane transporter activity Source: MGI
• negative regulation of epithelial cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• negative regulation of nephron tubule epithelial cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• negative regulation of sodium ion transmembrane transporter activity Source: MGI
• negative regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from genetic interactionⁱ
  • 21262216
• odontogenesis Source: UniProtKBInferred from genetic interactionⁱ
  • 19389375
• osmosensory signaling pathway Source: MGI
• pattern specification involved in metanephros development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18835385
• peptidyl-threonine phosphorylation Source: MGI
• positive regulation of bone mineralization Source: BHF-UCLInferred from genetic interactionⁱ
  • 21262216
• positive regulation of epithelial cell proliferation Source: UniProtKBInferred from genetic interactionⁱ
  • 19389375
• positive regulation of gastrulation Source: UniProtKB
• positive regulation of gene expression Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • 17547533
• posterior mesonephric tubule development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• pronephros development Source: UniProtKB
• renal vesicle progenitor cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18835385
• roof of mouth development Source: UniProtKBInferred from genetic interactionⁱ
  • 19389375
• signal transduction by trans-phosphorylation Source: MGI
• specification of anterior mesonephric tubule identity Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• specification of posterior mesonephric tubule identity Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• stem cell differentiation Source: UniProtKBInferred from direct assayⁱ
  • 20171952
• ureteric bud development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16790474
• ureter urothelium development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 18835385
• urogenital system development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16223478

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV 
        60         70         80         90        100
HLHQWTLGYP AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP 
       110        120        130        140        150
EITAGGSGAA LKTKPRFDFA NLALAATQED PTKLGRGEGP GSPAGGLGAL 
       160        170        180        190        200
LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE 
       210        220        230        240        250
RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK 
       260 
TLHSQVKELK TSKIKC                                      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot