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Protein

Protein odd-skipped-related 1

Gene

Osr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri175 – 197C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped-related 1
Gene namesi
Name:Osr1
Synonyms:Odd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1344424 Osr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice die prenatally with severe heart defects including defective atrioventricular junction and venous valves. They never initiate metanephric kidney formation. Nephrogenic mesenchyme undergo massive apoptosis, which causes a disruption of nephric duct elongation and failure of metanephric induction.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470051 – 266Protein odd-skipped-related 1Add BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9WVG7
PRIDEiQ9WVG7

PTM databases

iPTMnetiQ9WVG7
PhosphoSitePlusiQ9WVG7

Expressioni

Developmental stagei

During early embryogenesis it is expressed in the intermediate mesoderm and in a dynamic pattern during limb and branchial arch development. Is expressed from the earliest stage of intermediate development. Is expressed in the dorsal atrial wall, including the developing primary atrial septum and the venous valve.1 Publication

Inductioni

Transcriptionally regulated by Ikzf1 and Runx2.1 Publication

Gene expression databases

BgeeiENSMUSG00000048387 Expressed in 217 organ(s), highest expression level in dorsal pancreas
CleanExiMM_OSR1
ExpressionAtlasiQ9WVG7 baseline and differential
GenevisibleiQ9WVG7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204828, 1 interactor
STRINGi10090.ENSMUSP00000055486

Structurei

3D structure databases

ProteinModelPortaliQ9WVG7
SMRiQ9WVG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri175 – 197C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00880000137939
HOGENOMiHOG000013107
HOVERGENiHBG054398
InParanoidiQ9WVG7
KOiK09215
OMAiGPALKTK
OrthoDBiEOG091G0LRE
PhylomeDBiQ9WVG7
TreeFamiTF350876

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WVG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV
60 70 80 90 100
HLHQWTLGYP AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP
110 120 130 140 150
EITAGGSGAA LKTKPRFDFA NLALAATQED PTKLGRGEGP GSPAGGLGAL
160 170 180 190 200
LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE
210 220 230 240 250
RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK
260
TLHSQVKELK TSKIKC
Length:266
Mass (Da):29,584
Last modified:November 1, 1999 - v1
Checksum:iCC9948ACFC90F7A5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7S2A0A1W2P7S2_MOUSE
Protein odd-skipped-related 1
Osr1
161Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117814 mRNA Translation: AAD37115.1
BC023922 mRNA Translation: AAH23922.1
CCDSiCCDS25809.1
RefSeqiNP_035989.1, NM_011859.3
UniGeneiMm.45055

Genome annotation databases

EnsembliENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387
GeneIDi23967
KEGGimmu:23967
UCSCiuc007nao.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117814 mRNA Translation: AAD37115.1
BC023922 mRNA Translation: AAH23922.1
CCDSiCCDS25809.1
RefSeqiNP_035989.1, NM_011859.3
UniGeneiMm.45055

3D structure databases

ProteinModelPortaliQ9WVG7
SMRiQ9WVG7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204828, 1 interactor
STRINGi10090.ENSMUSP00000055486

PTM databases

iPTMnetiQ9WVG7
PhosphoSitePlusiQ9WVG7

Proteomic databases

PaxDbiQ9WVG7
PRIDEiQ9WVG7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387
GeneIDi23967
KEGGimmu:23967
UCSCiuc007nao.2 mouse

Organism-specific databases

CTDi130497
MGIiMGI:1344424 Osr1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00880000137939
HOGENOMiHOG000013107
HOVERGENiHBG054398
InParanoidiQ9WVG7
KOiK09215
OMAiGPALKTK
OrthoDBiEOG091G0LRE
PhylomeDBiQ9WVG7
TreeFamiTF350876

Miscellaneous databases

PROiPR:Q9WVG7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048387 Expressed in 217 organ(s), highest expression level in dorsal pancreas
CleanExiMM_OSR1
ExpressionAtlasiQ9WVG7 baseline and differential
GenevisibleiQ9WVG7 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOSR1_MOUSE
AccessioniPrimary (citable) accession number: Q9WVG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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