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UniProtKB - Q9WVG7 (OSR1_MOUSE)
Protein
Protein odd-skipped-related 1
Gene
Osr1
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 175 – 197 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 203 – 225 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 231 – 253 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell differentiation Source: BHF-UCL
- cell proliferation involved in kidney development Source: UniProtKB
- cellular response to retinoic acid Source: UniProtKB
- chondrocyte differentiation Source: BHF-UCL
- embryonic digit morphogenesis Source: BHF-UCL
- embryonic forelimb morphogenesis Source: BHF-UCL
- embryonic hindlimb morphogenesis Source: BHF-UCL
- embryonic skeletal joint development Source: BHF-UCL
- embryonic skeletal joint morphogenesis Source: BHF-UCL
- embryonic skeletal limb joint morphogenesis Source: BHF-UCL
- gonad development Source: MGI
- heart development Source: UniProtKB
- intermediate mesoderm development Source: MGI
- mesangial cell development Source: UniProtKB
- mesonephric duct morphogenesis Source: UniProtKB
- mesonephros development Source: UniProtKB
- metanephric cap mesenchymal cell proliferation involved in metanephros development Source: UniProtKB
- metanephric epithelium development Source: UniProtKB
- metanephric glomerulus vasculature development Source: UniProtKB
- metanephric interstitial fibroblast development Source: UniProtKB
- metanephric mesenchymal cell differentiation Source: UniProtKB
- metanephric mesenchyme development Source: UniProtKB
- metanephric mesenchyme morphogenesis Source: UniProtKB
- metanephric nephron tubule development Source: UniProtKB
- metanephric smooth muscle tissue development Source: UniProtKB
- metanephros development Source: MGI
- middle ear morphogenesis Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of creatine transmembrane transporter activity Source: MGI
- negative regulation of epithelial cell differentiation Source: UniProtKB
- negative regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
- negative regulation of sodium ion transmembrane transporter activity Source: MGI
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- odontogenesis Source: UniProtKB
- pattern specification involved in metanephros development Source: UniProtKB
- positive regulation of bone mineralization Source: BHF-UCL
- positive regulation of epithelial cell proliferation Source: UniProtKB
- positive regulation of gastrulation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- posterior mesonephric tubule development Source: UniProtKB
- pronephros development Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- renal vesicle progenitor cell differentiation Source: UniProtKB
- roof of mouth development Source: UniProtKB
- specification of anterior mesonephric tubule identity Source: UniProtKB
- specification of posterior mesonephric tubule identity Source: UniProtKB
- stem cell differentiation Source: UniProtKB
- ureteric bud development Source: UniProtKB
- ureter urothelium development Source: UniProtKB
- urogenital system development Source: UniProtKB
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Protein odd-skipped-related 1 |
Gene namesi | Name:Osr1 Synonyms:Odd1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1344424, Osr1 |
VEuPathDBi | HostDB:ENSMUSG00000048387 |
Subcellular locationi
Nucleus
- Nucleus Curated
Cytosol
- cytosol Source: MGI
Nucleus
- nucleus Source: UniProtKB
Other locations
- extrinsic component of membrane Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Mice die prenatally with severe heart defects including defective atrioventricular junction and venous valves. They never initiate metanephric kidney formation. Nephrogenic mesenchyme undergo massive apoptosis, which causes a disruption of nephric duct elongation and failure of metanephric induction.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047005 | 1 – 266 | Protein odd-skipped-related 1Add BLAST | 266 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 116 | Asymmetric dimethylarginineCombined sources | 1 |
Keywords - PTMi
MethylationProteomic databases
PaxDbi | Q9WVG7 |
PRIDEi | Q9WVG7 |
ProteomicsDBi | 293530 |
PTM databases
iPTMneti | Q9WVG7 |
PhosphoSitePlusi | Q9WVG7 |
Expressioni
Developmental stagei
During early embryogenesis it is expressed in the intermediate mesoderm and in a dynamic pattern during limb and branchial arch development. Is expressed from the earliest stage of intermediate development. Is expressed in the dorsal atrial wall, including the developing primary atrial septum and the venous valve.1 Publication
Inductioni
Transcriptionally regulated by Ikzf1 and Runx2.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000048387, Expressed in dorsal pancreas and 241 other tissues |
ExpressionAtlasi | Q9WVG7, baseline and differential |
Genevisiblei | Q9WVG7, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 204828, 1 interactor |
STRINGi | 10090.ENSMUSP00000055486 |
Miscellaneous databases
RNActi | Q9WVG7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Odd C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 175 – 197 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 203 – 225 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 231 – 253 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158993 |
HOGENOMi | CLU_051854_0_0_1 |
InParanoidi | Q9WVG7 |
OMAi | PLPAFPW |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9WVG7 |
TreeFami | TF350876 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9WVG7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV
60 70 80 90 100
HLHQWTLGYP AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP
110 120 130 140 150
EITAGGSGAA LKTKPRFDFA NLALAATQED PTKLGRGEGP GSPAGGLGAL
160 170 180 190 200
LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE
210 220 230 240 250
RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK
260
TLHSQVKELK TSKIKC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2P7S2 | A0A1W2P7S2_MOUSE | Protein odd-skipped-related 1 | Osr1 | 161 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117814 mRNA Translation: AAD37115.1 BC023922 mRNA Translation: AAH23922.1 |
CCDSi | CCDS25809.1 |
RefSeqi | NP_035989.1, NM_011859.3 |
Genome annotation databases
Ensembli | ENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387 |
GeneIDi | 23967 |
KEGGi | mmu:23967 |
UCSCi | uc007nao.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117814 mRNA Translation: AAD37115.1 BC023922 mRNA Translation: AAH23922.1 |
CCDSi | CCDS25809.1 |
RefSeqi | NP_035989.1, NM_011859.3 |
3D structure databases
SMRi | Q9WVG7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204828, 1 interactor |
STRINGi | 10090.ENSMUSP00000055486 |
PTM databases
iPTMneti | Q9WVG7 |
PhosphoSitePlusi | Q9WVG7 |
Proteomic databases
PaxDbi | Q9WVG7 |
PRIDEi | Q9WVG7 |
ProteomicsDBi | 293530 |
Protocols and materials databases
Antibodypediai | 12948, 372 antibodies from 30 providers |
DNASUi | 23967 |
Genome annotation databases
Ensembli | ENSMUST00000057021; ENSMUSP00000055486; ENSMUSG00000048387 |
GeneIDi | 23967 |
KEGGi | mmu:23967 |
UCSCi | uc007nao.2, mouse |
Organism-specific databases
CTDi | 130497 |
MGIi | MGI:1344424, Osr1 |
VEuPathDBi | HostDB:ENSMUSG00000048387 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158993 |
HOGENOMi | CLU_051854_0_0_1 |
InParanoidi | Q9WVG7 |
OMAi | PLPAFPW |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9WVG7 |
TreeFami | TF350876 |
Miscellaneous databases
BioGRID-ORCSi | 23967, 2 hits in 63 CRISPR screens |
ChiTaRSi | Osr1, mouse |
PROi | PR:Q9WVG7 |
RNActi | Q9WVG7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000048387, Expressed in dorsal pancreas and 241 other tissues |
ExpressionAtlasi | Q9WVG7, baseline and differential |
Genevisiblei | Q9WVG7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | OSR1_MOUSE | |
Accessioni | Q9WVG7Primary (citable) accession number: Q9WVG7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families