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Protein

Tumor suppressor candidate 2

Gene

Tusc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 2
Alternative name(s):
Fusion 1 protein
Short name:
Fus-1 protein
PDGFA-associated protein 2
Gene namesi
Name:Tusc2
Synonyms:Fus1, Lgcc, Pdap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1931086 Tusc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001481712 – 110Tumor suppressor candidate 2Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei50PhosphoserineCombined sources1

Post-translational modificationi

Myristoylation is required for tumor suppressor activity.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ9WVF8
PaxDbiQ9WVF8
PRIDEiQ9WVF8

PTM databases

iPTMnetiQ9WVF8
PhosphoSitePlusiQ9WVF8

Expressioni

Gene expression databases

BgeeiENSMUSG00000010054 Expressed in 251 organ(s), highest expression level in brain
CleanExiMM_TUSC2
ExpressionAtlasiQ9WVF8 baseline and differential
GenevisibleiQ9WVF8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000010198

Structurei

3D structure databases

ProteinModelPortaliQ9WVF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUSC2 family.Curated

Phylogenomic databases

eggNOGiENOG410IYM4 Eukaryota
ENOG4111PVZ LUCA
GeneTreeiENSGT00390000008040
HOGENOMiHOG000007342
HOVERGENiHBG054202
InParanoidiQ9WVF8
OMAiSKSKGFW
OrthoDBiEOG091G16LU
PhylomeDBiQ9WVF8
TreeFamiTF314634

Family and domain databases

InterProiView protein in InterPro
IPR029393 FUS1
PANTHERiPTHR15453 PTHR15453, 1 hit
PfamiView protein in Pfam
PF15000 TUSC2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WVF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGASGSKARG LWPFASTPGG GGPEAAGSEQ SLVRSRARAV PPFVFTRRGS
60 70 80 90 100
MFYDEDGDLA HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDPPRIH
110
VDFPVILYEV
Length:110
Mass (Da):12,136
Last modified:January 23, 2007 - v3
Checksum:i310698A5CB12DC40
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWP5A0A0A6YWP5_MOUSE
Tumor suppressor candidate 2
Tusc2
102Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123387 mRNA Translation: AAD42286.1
BC048477 mRNA Translation: AAH48477.1
CCDSiCCDS23495.1
RefSeqiNP_062716.1, NM_019742.4
UniGeneiMm.21739

Genome annotation databases

EnsembliENSMUST00000010198; ENSMUSP00000010198; ENSMUSG00000010054
GeneIDi80385
KEGGimmu:80385
UCSCiuc009rls.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123387 mRNA Translation: AAD42286.1
BC048477 mRNA Translation: AAH48477.1
CCDSiCCDS23495.1
RefSeqiNP_062716.1, NM_019742.4
UniGeneiMm.21739

3D structure databases

ProteinModelPortaliQ9WVF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000010198

PTM databases

iPTMnetiQ9WVF8
PhosphoSitePlusiQ9WVF8

Proteomic databases

MaxQBiQ9WVF8
PaxDbiQ9WVF8
PRIDEiQ9WVF8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010198; ENSMUSP00000010198; ENSMUSG00000010054
GeneIDi80385
KEGGimmu:80385
UCSCiuc009rls.1 mouse

Organism-specific databases

CTDi11334
MGIiMGI:1931086 Tusc2

Phylogenomic databases

eggNOGiENOG410IYM4 Eukaryota
ENOG4111PVZ LUCA
GeneTreeiENSGT00390000008040
HOGENOMiHOG000007342
HOVERGENiHBG054202
InParanoidiQ9WVF8
OMAiSKSKGFW
OrthoDBiEOG091G16LU
PhylomeDBiQ9WVF8
TreeFamiTF314634

Miscellaneous databases

PROiPR:Q9WVF8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010054 Expressed in 251 organ(s), highest expression level in brain
CleanExiMM_TUSC2
ExpressionAtlasiQ9WVF8 baseline and differential
GenevisibleiQ9WVF8 MM

Family and domain databases

InterProiView protein in InterPro
IPR029393 FUS1
PANTHERiPTHR15453 PTHR15453, 1 hit
PfamiView protein in Pfam
PF15000 TUSC2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTUSC2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 105 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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