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Protein

Group IID secretory phospholipase A2

Gene

Pla2g2d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+Note: Binds 1 Ca2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Calcium; via carbonyl oxygenBy similarity1
Metal bindingi48Calcium; via carbonyl oxygenBy similarity1
Metal bindingi50Calcium; via carbonyl oxygenBy similarity1
Active sitei66By similarity1
Metal bindingi67CalciumBy similarity1
Active sitei111By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1482788 Acyl chain remodelling of PC
R-MMU-1482801 Acyl chain remodelling of PS
R-MMU-1482839 Acyl chain remodelling of PE
R-MMU-1482922 Acyl chain remodelling of PI
R-MMU-1482925 Acyl chain remodelling of PG
R-MMU-1483166 Synthesis of PA

Names & Taxonomyi

Protein namesi
Recommended name:
Group IID secretory phospholipase A2 (EC:3.1.1.4)
Short name:
GIID sPLA2
Short name:
sPLA2-IID
Alternative name(s):
PLA2IID
Phosphatidylcholine 2-acylhydrolase 2D
Secretory-type PLA, stroma-associated homolog
Gene namesi
Name:Pla2g2d
Synonyms:Pla2a2, Splash
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1341796 Pla2g2d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5537

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002275620 – 144Group IID secretory phospholipase A2Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 137By similarity
Disulfide bondi47 ↔ 63By similarity
Disulfide bondi62 ↔ 117By similarity
Disulfide bondi68 ↔ 144By similarity
Disulfide bondi69 ↔ 110By similarity
Disulfide bondi78 ↔ 103By similarity
Disulfide bondi96 ↔ 108By similarity
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WVF6
PRIDEiQ9WVF6

PTM databases

PhosphoSitePlusiQ9WVF6

Expressioni

Tissue specificityi

Expressed in several tissues including pancreas, spleen, thymus, skin, lung, and ovary.

Gene expression databases

BgeeiENSMUSG00000041202 Expressed in 66 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_PLA2G2D
ExpressionAtlasiQ9WVF6 baseline and differential
GenevisibleiQ9WVF6 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030528

Chemistry databases

BindingDBiQ9WVF6

Structurei

3D structure databases

ProteinModelPortaliQ9WVF6
SMRiQ9WVF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4087 Eukaryota
ENOG411283D LUCA
GeneTreeiENSGT00760000119160
HOGENOMiHOG000231749
HOVERGENiHBG008137
InParanoidiQ9WVF6
KOiK01047
OMAiGDIQCSD
OrthoDBiEOG091G0UZ3
PhylomeDBiQ9WVF6
TreeFamiTF319283

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9WVF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLALLCGLL LAGITATQGG LLNLNKMVTH MTGKKAFFSY WPYGCHCGLG
60 70 80 90 100
GKGQPKDATD WCCQKHDCCY AHLKIDGCKS LTDNYKYSIS QGTIQCSDNG
110 120 130 140
SWCERQLCAC DKEVALCLKQ NLDSYNKRLR YYWRPRCKGK TPAC
Length:144
Mass (Da):16,164
Last modified:November 1, 1999 - v1
Checksum:i7697ADA07F8D270A
GO
Isoform 2 (identifier: Q9WVF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.

Show »
Length:118
Mass (Da):13,514
Checksum:i7B6332239725E782
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0045081 – 26Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112983 mRNA Translation: AAD51391.1
AF124374 mRNA Translation: AAD42773.1
AF188624 Genomic DNA Translation: AAF09019.1
AF169407 mRNA Translation: AAF42987.1
AF169408 mRNA Translation: AAF42988.1
AK004232 mRNA Translation: BAE43166.1
AK018005 mRNA Translation: BAB31033.1
CCDSiCCDS18833.1 [Q9WVF6-1]
CCDS84811.1 [Q9WVF6-2]
RefSeqiNP_001334159.1, NM_001347230.1 [Q9WVF6-2]
NP_035239.1, NM_011109.2 [Q9WVF6-1]
UniGeneiMm.71913

Genome annotation databases

EnsembliENSMUST00000030528; ENSMUSP00000030528; ENSMUSG00000041202 [Q9WVF6-1]
ENSMUST00000105806; ENSMUSP00000101432; ENSMUSG00000041202 [Q9WVF6-2]
GeneIDi18782
KEGGimmu:18782
UCSCiuc008vlg.1 mouse [Q9WVF6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112983 mRNA Translation: AAD51391.1
AF124374 mRNA Translation: AAD42773.1
AF188624 Genomic DNA Translation: AAF09019.1
AF169407 mRNA Translation: AAF42987.1
AF169408 mRNA Translation: AAF42988.1
AK004232 mRNA Translation: BAE43166.1
AK018005 mRNA Translation: BAB31033.1
CCDSiCCDS18833.1 [Q9WVF6-1]
CCDS84811.1 [Q9WVF6-2]
RefSeqiNP_001334159.1, NM_001347230.1 [Q9WVF6-2]
NP_035239.1, NM_011109.2 [Q9WVF6-1]
UniGeneiMm.71913

3D structure databases

ProteinModelPortaliQ9WVF6
SMRiQ9WVF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030528

Chemistry databases

BindingDBiQ9WVF6
ChEMBLiCHEMBL5537

PTM databases

PhosphoSitePlusiQ9WVF6

Proteomic databases

PaxDbiQ9WVF6
PRIDEiQ9WVF6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030528; ENSMUSP00000030528; ENSMUSG00000041202 [Q9WVF6-1]
ENSMUST00000105806; ENSMUSP00000101432; ENSMUSG00000041202 [Q9WVF6-2]
GeneIDi18782
KEGGimmu:18782
UCSCiuc008vlg.1 mouse [Q9WVF6-1]

Organism-specific databases

CTDi26279
MGIiMGI:1341796 Pla2g2d

Phylogenomic databases

eggNOGiKOG4087 Eukaryota
ENOG411283D LUCA
GeneTreeiENSGT00760000119160
HOGENOMiHOG000231749
HOVERGENiHBG008137
InParanoidiQ9WVF6
KOiK01047
OMAiGDIQCSD
OrthoDBiEOG091G0UZ3
PhylomeDBiQ9WVF6
TreeFamiTF319283

Enzyme and pathway databases

ReactomeiR-MMU-1482788 Acyl chain remodelling of PC
R-MMU-1482801 Acyl chain remodelling of PS
R-MMU-1482839 Acyl chain remodelling of PE
R-MMU-1482922 Acyl chain remodelling of PI
R-MMU-1482925 Acyl chain remodelling of PG
R-MMU-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRSiPla2g2d mouse
PROiPR:Q9WVF6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041202 Expressed in 66 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_PLA2G2D
ExpressionAtlasiQ9WVF6 baseline and differential
GenevisibleiQ9WVF6 MM

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPA2GD_MOUSE
AccessioniPrimary (citable) accession number: Q9WVF6
Secondary accession number(s): Q3V4B8, Q9JLK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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