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Protein

Short transient receptor potential channel 7

Gene

Trpc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion.

GO - Molecular functioni

  • calcium channel activity Source: MGI
  • store-operated calcium channel activity Source: GO_Central

GO - Biological processi

  • calcium ion transport Source: MGI
  • manganese ion transport Source: MGI
  • regulation of cytosolic calcium ion concentration Source: GO_Central
  • single fertilization Source: GO_Central

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-114508 Effects of PIP2 hydrolysis
R-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-3295583 TRP channels

Protein family/group databases

TCDBi1.A.4.1.2 the transient receptor potential ca(2+) channel (trp-cc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 7
Short name:
TrpC7
Alternative name(s):
Transient receptor protein 7
Short name:
TRP-7
Short name:
mTRP7
Gene namesi
Name:Trpc7
Synonyms:Trp7, Trrp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1349470 Trpc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 351CytoplasmicSequence analysisAdd BLAST351
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 383ExtracellularSequence analysisAdd BLAST11
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 465CytoplasmicSequence analysisAdd BLAST61
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 537ExtracellularSequence analysisAdd BLAST51
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 581CytoplasmicSequence analysisAdd BLAST23
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 651ExtracellularSequence analysisAdd BLAST49
Transmembranei652 – 672HelicalSequence analysisAdd BLAST21
Topological domaini673 – 862CytoplasmicSequence analysisAdd BLAST190

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi492

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153251 – 862Short transient receptor potential channel 7Add BLAST862

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15Phosphothreonine; by PKG/PRKG1By similarity1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9WVC5
PaxDbiQ9WVC5
PRIDEiQ9WVC5

PTM databases

iPTMnetiQ9WVC5
PhosphoSitePlusiQ9WVC5

Expressioni

Gene expression databases

BgeeiENSMUSG00000021541
ExpressionAtlasiQ9WVC5 baseline and differential
GenevisibleiQ9WVC5 MM

Interactioni

Subunit structurei

Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022023

Structurei

3D structure databases

ProteinModelPortaliQ9WVC5
SMRiQ9WVC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 71ANK 1Add BLAST30
Repeati77 – 106ANK 2Add BLAST30
Repeati108 – 134ANK 3Add BLAST27
Repeati163 – 192ANK 4Add BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020590
HOVERGENiHBG068337
InParanoidiQ9WVC5
KOiK04970
OMAiSEQCKQY
OrthoDBiEOG091G01FB
PhylomeDBiQ9WVC5
TreeFamiTF313147

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005463 TRPC7_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF9 PTHR10117:SF9, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01648 TRPCHANNEL7
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WVC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSNTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS
60 70 80 90 100
AEYGNIPVVR KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK
110 120 130 140 150
ENLARVGDAL LLAISKGYVR IVEAILSHPA FAQGQRLTLS PLEQELRDDD
160 170 180 190 200
FYAYDEDGTR FSHDITPIIL AAHCQEYEIV HILLLKGARI ERPHDYFCKC
210 220 230 240 250
NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL TALELSNELA
260 270 280 290 300
RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNLQVW
310 320 330 340 350
SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV
360 370 380 390 400
KFLAVFGVSI GLPFLAIAYW IAPCSKLGQT LRSPFMKFVA HAVSFTIFLG
410 420 430 440 450
LLVVNASDRF EGVKTLPNET FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM
460 470 480 490 500
IWSECKEIWE EGPREYVLHL WNLLDFGMLS IFVASFTARF MAFLKASEAQ
510 520 530 540 550
LYVDQYVQDV TLHNVSLPPE VAYFTYARDK WWPSDPQIIS EGLYAIAVVL
560 570 580 590 600
SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL
610 620 630 640 650
YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY
660 670 680 690 700
VLYGVYNVTM VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD
710 720 730 740 750
EGRTLPAPFN LVPSPKSFYY LIMRIKMCLI ELCQSKAKRC ENDLEMGMLN
760 770 780 790 800
SKFRKTRYQA GMRNSENLTA NSTFSKPTRY QKIMKRLIKR YVLKAQVDRE
810 820 830 840 850
NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ LSEKFGKNLN
860
KDHLRVNQGK DI
Length:862
Mass (Da):99,475
Last modified:November 1, 1999 - v1
Checksum:iC2EB2CE1A6AF9C3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139923 mRNA Translation: AAD42069.1
CCDSiCCDS26566.1
RefSeqiNP_036165.1, NM_012035.3
UniGeneiMm.62409

Genome annotation databases

EnsembliENSMUST00000022023; ENSMUSP00000022023; ENSMUSG00000021541
GeneIDi26946
KEGGimmu:26946
UCSCiuc007qtb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTRPC7_MOUSE
AccessioniPrimary (citable) accession number: Q9WVC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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