Segment polarity protein dishevelled homolog DVL-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: Ensembl
• frizzled binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: Ensembl
• protein kinase binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway."
    Aschenbach W.G., Ho R.C., Sakamoto K., Fujii N., Li Y., Kim Y.B., Hirshman M.F., Goodyear L.J.
    Am. J. Physiol. Endocrinol. Metab. 291:E152-8(2006) [PubMed] [Europe PMC] [Abstract]
• Rac GTPase binding Source: RGDInferred from physical interactionⁱ
  • "Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development."
    Rosso S.B., Sussman D., Wynshaw-Boris A., Salinas P.C.
    Nat. Neurosci. 8:34-42(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• axon extension Source: Ensembl
• axon guidance Source: Ensembl
• canonical Wnt signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cochlea morphogenesis Source: Ensembl
• collateral sprouting Source: Ensembl
• convergent extension involved in neural plate elongation Source: Ensembl
• cytoplasmic microtubule organization Source: Ensembl
• dendritic spine morphogenesis Source: ParkinsonsUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca^2⁺/Calmodulin-dependent protein kinase II."
    Ciani L., Boyle K.A., Dickins E., Sahores M., Anane D., Lopes D.M., Gibb A.J., Salinas P.C.
    Proc. Natl. Acad. Sci. U.S.A. 108:10732-10737(2011) [PubMed] [Europe PMC] [Abstract]
• intracellular signal transduction Source: InterPro
• negative regulation of protein binding Source: Ensembl
• negative regulation of protein kinase activity Source: Ensembl
• neurotransmitter secretion Source: Ensembl
• planar cell polarity pathway involved in neural tube closure Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of excitatory postsynaptic potential Source: ParkinsonsUK-UCLInferred from genetic interactionⁱ
  • "Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca^2⁺/Calmodulin-dependent protein kinase II."
    Ciani L., Boyle K.A., Dickins E., Sahores M., Anane D., Lopes D.M., Gibb A.J., Salinas P.C.
    Proc. Natl. Acad. Sci. U.S.A. 108:10732-10737(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron projection arborization Source: ARUK-UCLInferred from genetic interactionⁱ
  • "A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4."
    Bian W.J., Miao W.Y., He S.J., Wan Z.F., Luo Z.G., Yu X.
    Dev Neurobiol 75:805-822(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
• positive regulation of protein phosphorylation Source: Ensembl
• positive regulation of transcription, DNA-templated Source: Ensembl
• prepulse inhibition Source: Ensembl
• presynapse assembly Source: Ensembl
• protein localization to microtubule Source: Ensembl
• protein localization to nucleus Source: Ensembl
• protein stabilization Source: Ensembl
• regulation of cellular protein localization Source: Ensembl
• regulation of synaptic vesicle exocytosis Source: Ensembl
• skeletal muscle acetylcholine-gated channel clustering Source: Ensembl
• social behavior Source: Ensembl
• transcription by RNA polymerase II Source: Ensembl
• Wnt signaling pathway Source: ParkinsonsUK-UCLInferred from genetic interactionⁱ
  • "Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca^2⁺/Calmodulin-dependent protein kinase II."
    Ciani L., Boyle K.A., Dickins E., Sahores M., Anane D., Lopes D.M., Gibb A.J., Salinas P.C.
    Proc. Natl. Acad. Sci. U.S.A. 108:10732-10737(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• beta-catenin binding Source: Ensembl
• frizzled binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: Ensembl
• protein kinase binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway."
    Aschenbach W.G., Ho R.C., Sakamoto K., Fujii N., Li Y., Kim Y.B., Hirshman M.F., Goodyear L.J.
    Am. J. Physiol. Endocrinol. Metab. 291:E152-8(2006) [PubMed] [Europe PMC] [Abstract]
• Rac GTPase binding Source: RGDInferred from physical interactionⁱ
  • "Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development."
    Rosso S.B., Sussman D., Wynshaw-Boris A., Salinas P.C.
    Nat. Neurosci. 8:34-42(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK 
        60         70         80         90        100
SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT 
       110        120        130        140        150
DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR 
       160        170        180        190        200
RNRDEAARTN GHPRGDRRRE LGLPPDSAST VLSSELESSS FIDSDEEDNT 
       210        220        230        240        250
SRLSSSTEQS TSSRLIRKHK CRRRKQRLRQ TDRASSFSSI TDSTMSLNII 
       260        270        280        290        300
TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 
       310        320        330        340        350
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTIP 
       360        370        380        390        400
RADPVRPIDP AAWLSHTAAL TGALPRYGTS PCSSAITRTS SSSLTSSVPG 
       410        420        430        440        450
APQLEEAPLT VKSDMSAIVR VMQLPDSGLE IRDRMWLKIT IANAVIGADV 
       460        470        480        490        500
VDWLYTHVEG FKERREARKY ASSMLKHGFL RHTVNKITFS EQCYYVFGDL 
       510        520        530        540        550
CSNLASLNLN SGSSGASDQD TLAPLPHPSV PWPLGQGYPY QYPGPPPCFP 
       560        570        580        590        600
PAYQDPGFSY GSGSAGSQQS EGSKSSGSTR SSHRTPGREE RRATGAGGSG 
       610        620        630        640        650
SESDHTVPSG SGSTGWWERP VSQLSRGSSP RSQASAVAPG LPPLHPLTKA 
       660        670        680        690 
YAVVGGPPGG PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families