UniProtKB - Q9WVB9 (DVL1_RAT)
Segment polarity protein dishevelled homolog DVL-1
Dvl1
Functioni
GO - Molecular functioni
- beta-catenin binding Source: RGD
- enzyme binding Source: RGD
- frizzled binding Source: RGD
- identical protein binding Source: RGD
- protein kinase binding Source: RGD
- small GTPase binding Source: RGD
GO - Biological processi
- axon extension Source: RGD
- axon guidance Source: RGD
- axonogenesis Source: RGD
- canonical Wnt signaling pathway Source: RGD
- cochlea morphogenesis Source: RGD
- collateral sprouting Source: RGD
- convergent extension involved in neural plate elongation Source: RGD
- convergent extension involved in organogenesis Source: RGD
- cytoplasmic microtubule organization Source: RGD
- dendrite morphogenesis Source: RGD
- dendritic spine morphogenesis Source: ParkinsonsUK-UCL
- intracellular signal transduction Source: InterPro
- negative regulation of protein binding Source: RGD
- negative regulation of protein kinase activity Source: RGD
- negative regulation of protein phosphorylation Source: RGD
- neural tube development Source: RGD
- neuromuscular junction development Source: RGD
- neurotransmitter secretion Source: RGD
- planar cell polarity pathway involved in neural tube closure Source: RGD
- positive regulation of excitatory postsynaptic potential Source: ParkinsonsUK-UCL
- positive regulation of neuron projection arborization Source: ARUK-UCL
- positive regulation of neuron projection development Source: RGD
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: RGD
- positive regulation of protein phosphorylation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- postsynapse organization Source: RGD
- prepulse inhibition Source: RGD
- presynapse assembly Source: RGD
- protein localization to microtubule Source: RGD
- protein localization to nucleus Source: RGD
- protein stabilization Source: RGD
- receptor clustering Source: RGD
- regulation of cellular protein localization Source: RGD
- regulation of neurotransmitter levels Source: RGD
- regulation of protein phosphorylation Source: RGD
- regulation of synaptic vesicle exocytosis Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- skeletal muscle acetylcholine-gated channel clustering Source: RGD
- social behavior Source: RGD
- synapse organization Source: RGD
- Wnt signaling pathway Source: ParkinsonsUK-UCL
- Wnt signaling pathway, planar cell polarity pathway Source: RGD
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-RNO-201688, WNT mediated activation of DVL R-RNO-4086400, PCP/CE pathway R-RNO-4641258, Degradation of DVL R-RNO-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-RNO-5663220, RHO GTPases Activate Formins |
Names & Taxonomyi
Protein namesi | Recommended name: Segment polarity protein dishevelled homolog DVL-1Short name: Dishevelled-1 Alternative name(s): DSH homolog 1 |
Gene namesi | Name:Dvl1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620632, Dvl1 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- Cytoplasmic vesicle By similarity
Note: Localizes at the cell membrane upon interaction with frizzled family members.By similarity
Cytoskeleton
- microtubule cytoskeleton Source: MGI
Cytosol
- cytosol Source: RGD
Plasma Membrane
- lateral plasma membrane Source: RGD
- plasma membrane Source: UniProtKB
Other locations
- axon Source: RGD
- clathrin-coated vesicle Source: RGD
- cytoplasmic vesicle Source: RGD
- dendrite Source: RGD
- dendritic spine Source: ParkinsonsUK-UCL
- glutamatergic synapse Source: RGD
- growth cone Source: RGD
- neuron projection Source: RGD
- neuronal cell body Source: RGD
- postsynaptic density Source: ParkinsonsUK-UCL
- presynapse Source: RGD
- Schaffer collateral - CA1 synapse Source: RGD
- synapse Source: RGD
- Wnt signalosome Source: RGD
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoplasmic vesicle, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000145745 | 1 – 695 | Segment polarity protein dishevelled homolog DVL-1Add BLAST | 695 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 194 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q9WVB9 |
PRIDEi | Q9WVB9 |
PTM databases
iPTMneti | Q9WVB9 |
PhosphoSitePlusi | Q9WVB9 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000019423, Expressed in skeletal muscle tissue and 21 other tissues |
Genevisiblei | Q9WVB9, RN |
Interactioni
Subunit structurei
Interacts with BRD7 and INVS.
Interacts (via PDZ domain) with the VANGL1 and VANGL2 (via C-terminus).
Interacts (via PDZ domain) with NXN.
Interacts with CXXC4.
Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1.
Interacts with CYLD.
Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers.
Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site.
Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering.
Interacts (via PDZ domain) with TMEM88 (By similarity).
Interacts with DCDC2.
Interacts with FOXK2 (By similarity).
Interacts with PKD1 (via extracellular domain) (By similarity).
Interacts (via PDZ domain) with CCDC88C/DAPLE; competes with CCDC88C for binding to frizzled receptor FZD7 and dissociates from CCDC88C following initiation of non-canonical Wnt signaling when CCDC88C displaces DVL1 from ligand-activated FZD7 (By similarity).
By similarityGO - Molecular functioni
- beta-catenin binding Source: RGD
- enzyme binding Source: RGD
- frizzled binding Source: RGD
- identical protein binding Source: RGD
- protein kinase binding Source: RGD
- small GTPase binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 249815, 5 interactors |
IntActi | Q9WVB9, 1 interactor |
STRINGi | 10116.ENSRNOP00000026439 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 85 | DIXPROSITE-ProRule annotationAdd BLAST | 85 | |
Domaini | 251 – 323 | PDZPROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 425 – 499 | DEPPROSITE-ProRule annotationAdd BLAST | 75 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3571, Eukaryota |
GeneTreei | ENSGT00950000182903 |
HOGENOMi | CLU_012601_1_0_1 |
InParanoidi | Q9WVB9 |
OMAi | WWERPVS |
OrthoDBi | 474724at2759 |
PhylomeDBi | Q9WVB9 |
TreeFami | TF318198 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008340, DVL-1 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF5, PTHR10878:SF5, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK
60 70 80 90 100
SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT
110 120 130 140 150
DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR
160 170 180 190 200
RNRDEAARTN GHPRGDRRRE LGLPPDSAST VLSSELESSS FIDSDEEDNT
210 220 230 240 250
SRLSSSTEQS TSSRLIRKHK CRRRKQRLRQ TDRASSFSSI TDSTMSLNII
260 270 280 290 300
TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM
310 320 330 340 350
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTIP
360 370 380 390 400
RADPVRPIDP AAWLSHTAAL TGALPRYGTS PCSSAITRTS SSSLTSSVPG
410 420 430 440 450
APQLEEAPLT VKSDMSAIVR VMQLPDSGLE IRDRMWLKIT IANAVIGADV
460 470 480 490 500
VDWLYTHVEG FKERREARKY ASSMLKHGFL RHTVNKITFS EQCYYVFGDL
510 520 530 540 550
CSNLASLNLN SGSSGASDQD TLAPLPHPSV PWPLGQGYPY QYPGPPPCFP
560 570 580 590 600
PAYQDPGFSY GSGSAGSQQS EGSKSSGSTR SSHRTPGREE RRATGAGGSG
610 620 630 640 650
SESDHTVPSG SGSTGWWERP VSQLSRGSSP RSQASAVAPG LPPLHPLTKA
660 670 680 690
YAVVGGPPGG PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF143545 mRNA Translation: AAD33896.2 AF143546 mRNA Translation: AAD33897.2 AF143548, AF143547 Genomic DNA Translation: AAD41492.2 AF143550, AF143549 Genomic DNA Translation: AAD41493.1 |
RefSeqi | NP_114008.1, NM_031820.1 |
Genome annotation databases
Ensembli | ENSRNOT00000026439; ENSRNOP00000026439; ENSRNOG00000019423 |
GeneIDi | 83721 |
KEGGi | rno:83721 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF143545 mRNA Translation: AAD33896.2 AF143546 mRNA Translation: AAD33897.2 AF143548, AF143547 Genomic DNA Translation: AAD41492.2 AF143550, AF143549 Genomic DNA Translation: AAD41493.1 |
RefSeqi | NP_114008.1, NM_031820.1 |
3D structure databases
SMRi | Q9WVB9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 249815, 5 interactors |
IntActi | Q9WVB9, 1 interactor |
STRINGi | 10116.ENSRNOP00000026439 |
PTM databases
iPTMneti | Q9WVB9 |
PhosphoSitePlusi | Q9WVB9 |
Proteomic databases
PaxDbi | Q9WVB9 |
PRIDEi | Q9WVB9 |
Genome annotation databases
Ensembli | ENSRNOT00000026439; ENSRNOP00000026439; ENSRNOG00000019423 |
GeneIDi | 83721 |
KEGGi | rno:83721 |
Organism-specific databases
CTDi | 1855 |
RGDi | 620632, Dvl1 |
Phylogenomic databases
eggNOGi | KOG3571, Eukaryota |
GeneTreei | ENSGT00950000182903 |
HOGENOMi | CLU_012601_1_0_1 |
InParanoidi | Q9WVB9 |
OMAi | WWERPVS |
OrthoDBi | 474724at2759 |
PhylomeDBi | Q9WVB9 |
TreeFami | TF318198 |
Enzyme and pathway databases
Reactomei | R-RNO-201688, WNT mediated activation of DVL R-RNO-4086400, PCP/CE pathway R-RNO-4641258, Degradation of DVL R-RNO-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-RNO-5663220, RHO GTPases Activate Formins |
Miscellaneous databases
PROi | PR:Q9WVB9 |
Gene expression databases
Bgeei | ENSRNOG00000019423, Expressed in skeletal muscle tissue and 21 other tissues |
Genevisiblei | Q9WVB9, RN |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008340, DVL-1 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF5, PTHR10878:SF5, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DVL1_RAT | |
Accessioni | Q9WVB9Primary (citable) accession number: Q9WVB9 Secondary accession number(s): Q9QUG5, Q9WVB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | March 27, 2002 | |
Last modified: | April 7, 2021 | |
This is version 168 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families