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Entry version 161 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Slit homolog 3 protein

Gene

Slit3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-376176 Signaling by ROBO receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Slit homolog 3 protein
Short name:
Slit-3
Short name:
Slit3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slit3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1315202 Slit3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000773334 – 1523Slit homolog 3 proteinAdd BLAST1490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi284 ↔ 293By similarity
Disulfide bondi441 ↔ 464By similarity
Disulfide bondi443 ↔ 485By similarity
Disulfide bondi505 ↔ 511By similarity
Disulfide bondi509 ↔ 518By similarity
Glycosylationi563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi622N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi667 ↔ 690By similarity
Disulfide bondi669 ↔ 711By similarity
Glycosylationi784N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi792N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi797N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi920 ↔ 931By similarity
Disulfide bondi925 ↔ 941By similarity
Glycosylationi928N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi943 ↔ 952By similarity
Disulfide bondi959 ↔ 970By similarity
Disulfide bondi964 ↔ 982By similarity
Disulfide bondi984 ↔ 993By similarity
Disulfide bondi1000 ↔ 1011By similarity
Disulfide bondi1005 ↔ 1020By similarity
Disulfide bondi1022 ↔ 1031By similarity
Glycosylationi1025N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1038 ↔ 1051By similarity
Disulfide bondi1045 ↔ 1060By similarity
Disulfide bondi1062 ↔ 1071By similarity
Disulfide bondi1078 ↔ 1089By similarity
Disulfide bondi1083 ↔ 1098By similarity
Disulfide bondi1100 ↔ 1109By similarity
Disulfide bondi1123 ↔ 1134By similarity
Disulfide bondi1128 ↔ 1143By similarity
Disulfide bondi1145 ↔ 1154By similarity
Glycosylationi1181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1305 ↔ 1332By similarity
Disulfide bondi1355 ↔ 1364By similarity
Disulfide bondi1372 ↔ 1382By similarity
Disulfide bondi1377 ↔ 1391By similarity
Disulfide bondi1393 ↔ 1402By similarity
Glycosylationi1406N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1412 ↔ 1422By similarity
Disulfide bondi1417 ↔ 1432By similarity
Disulfide bondi1434 ↔ 1443By similarity
Disulfide bondi1449 ↔ 1487By similarity
Disulfide bondi1467 ↔ 1501By similarity
Disulfide bondi1478 ↔ 1517By similarity
Disulfide bondi1482 ↔ 1519By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9WVB4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9WVB4

PRoteomics IDEntifications database

More...
PRIDEi
Q9WVB4

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2717

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WVB4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected as early as 8.25 dpc in the ventral neural tube. From 9.5 dpc to 11.5 dpc is expressed in the floor plate and motor columns. This pattern of expression continued until at least 17.5 dpc and remained weak. Rostrally, at 8.25 dpc is expressed in the ventral midline of the neural groove and in the neural fold prior to closure of the neural tube. Between 8.5 dpc and 9.5 dpc, expression is observed in the ventral side of the mesencephalon and metencephalon and in the commissural plate after closure of the neural tube. After 13.5 dpc, the expression of SLIT3 is weak in the developing CNS. At 9.5 dpc, SLIT3 is detected in the otic vesicle and in the clefts between the first and the second branchial arches. Between 10.5 dpc and 11.5 dpc is prominently expressed in the otic vesicle but decreased in the branchial clefts. From 13.5 dpc to 17.5 dpc, expression is observed in the cochlea, in the pigment layer of the retina, and in the olfactory epithelium. At 13.5 dpc expression is observed in the whisker follicle surrounding the bulb and shaft. In the developing limb is first detected at 10.5 dpc in distal limb bud mesenchyme. At this stage, is also observed in lateral ridge tissue flanking the limb bud. This pattern persisted through 11.5 dpc but unlike with SLIT2, expression is not observed in the inter-limb bud lateral ridge tissue. At 11.5 dpc, expression in both the fore- and the hindlimb is most intense in the distal anterior mesenchyme and in the proximal posterior cleft between the limb bud and the lateral ridge. At 13.5 dpc could be detected in the wrist and weakly in palm and proximal part of the digits excluding the tips of the digits.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000056427 Expressed in 239 organ(s), highest expression level in dorsal pancreas

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9WVB4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
203329, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000066857

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 61LRRNTAdd BLAST28
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati62 – 83LRR 1Add BLAST22
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 131LRR 3Add BLAST22
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 179LRR 5Add BLAST22
Repeati182 – 203LRR 6Add BLAST22
Domaini215 – 265LRRCT 1Add BLAST51
Domaini271 – 307LRRNT 2Add BLAST37
Repeati308 – 329LRR 7Add BLAST22
Repeati332 – 353LRR 8Add BLAST22
Repeati356 – 377LRR 9Add BLAST22
Repeati380 – 401LRR 10Add BLAST22
Repeati404 – 425LRR 11Add BLAST22
Domaini437 – 487LRRCT 2Add BLAST51
Domaini496 – 532LRRNT 3Add BLAST37
Repeati533 – 554LRR 12Add BLAST22
Repeati558 – 579LRR 13Add BLAST22
Repeati582 – 603LRR 14Add BLAST22
Repeati606 – 627LRR 15Add BLAST22
Repeati630 – 651LRR 16Add BLAST22
Domaini663 – 713LRRCT 3Add BLAST51
Domaini716 – 752LRRNT 4Add BLAST37
Repeati753 – 774LRR 17Add BLAST22
Repeati776 – 797LRR 18Add BLAST22
Repeati800 – 821LRR 19Add BLAST22
Repeati824 – 845LRR 20Add BLAST22
Domaini857 – 907LRRCT 4Add BLAST51
Domaini918 – 953EGF-like 1PROSITE-ProRule annotationAdd BLAST36
Domaini955 – 994EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini996 – 1032EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini1034 – 1072EGF-like 4PROSITE-ProRule annotationAdd BLAST39
Domaini1074 – 1110EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini1119 – 1155EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini1158 – 1332Laminin G-likePROSITE-ProRule annotationAdd BLAST175
Domaini1340 – 1365EGF-like 7PROSITE-ProRule annotationAdd BLAST26
Domaini1368 – 1403EGF-like 8PROSITE-ProRule annotationAdd BLAST36
Domaini1408 – 1444EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini1449 – 1523CTCKPROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4237 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159322

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000116120

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9WVB4

KEGG Orthology (KO)

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KOi
K06850

Identification of Orthologs from Complete Genome Data

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OMAi
SVHGRMF

Database of Orthologous Groups

More...
OrthoDBi
28488at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332887

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 2 hits
PF02210 Laminin_G_2, 1 hit
PF13855 LRR_8, 5 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 9 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 18 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WVB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGRTGAGA AVRARLALGL ALASILSGPP AAACPTKCTC SAASVDCHGL
60 70 80 90 100
GLRAVPRGIP RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSII
110 120 130 140 150
ERGAFQDLKQ LERLRLNKNK LQVLPELLFQ STPKLTRLDL SENQIQGIPR
160 170 180 190 200
KAFRGVTGVK NLQLDNNHIS CIEDGAFRAL RDLEILTLNN NNISRILVTS
210 220 230 240 250
FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTIGQFT LCMAPVHLRG
260 270 280 290 300
FSVADVQKKE YVCPGPHSEA PACNANSLSC PSACSCSNNI VDCRGKGLTE
310 320 330 340 350
IPANLPEGIV EIRLEQNSIK SIPAGAFTQY KKLKRIDISK NQISDIAPDA
360 370 380 390 400
FQGLKSLTSL VLYGNKITEI PKGLFDGLVS LQLLLLNANK INCLRVNTFQ
410 420 430 440 450
DLQNLNLLSL YDNKLQTISK GLFVPLQSIQ TLHLAQNPFV CDCHLKWLAD
460 470 480 490 500
YLQDNPIETS GARCSSPRRL ANKRISQIKS KKFRCSGSED YRNRFSSECF
510 520 530 540 550
MDLVCPEKCR CEGTIVDCSN QKLARIPSHL PEYTTDLRLN DNDISVLEAT
560 570 580 590 600
GIFKKLPNLR KINLSNNRIK EVREGAFDGA AGVQELMLTG NQLETMHGRM
610 620 630 640 650
FRGLSSLKTL MLRSNLISCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT
660 670 680 690 700
TLVSLSTINL LSNPFNCNCH MAWLGRWLRK RRIVSGNPRC QKPFFLKEIP
710 720 730 740 750
IQDVAIQDFT CDGNEESSCQ LSPRCPEQCT CVETVVRCSN RGLHALPKGM
760 770 780 790 800
PKDVTELYLE GNHLTAVPKE LSAFRQLTLI DLSNNSISML TNHTFSNMSH
810 820 830 840 850
LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE GSFNDLTSLS
860 870 880 890 900
HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPESM ADRLLLTTPT
910 920 930 940 950
HRFQCKGPVD INIVAKCNAC LSSPCKNNGT CSQDPVEQYR CTCPYSYKGK
960 970 980 990 1000
DCTVPINTCV QNPCEHGGTC HLSENLRDGF SCSCPLGFEG QRCEINPDDC
1010 1020 1030 1040 1050
EDNDCENSAT CVDGINNYAC LCPPNYTGEL CDEVIDYCVP EMNLCQHEAK
1060 1070 1080 1090 1100
CISLDKGFRC ECVPGYSGKL CETNNDDCVA HKCRHGAQCV DEVNGYTCIC
1110 1120 1130 1140 1150
PQGFSGLFCE HPPPMVLLQT SPCDQYECQN GAQCIVVQQE PTCRCPPGFA
1160 1170 1180 1190 1200
GPRCEKLITV NFVGKDSYVE LASAKVRPQA NISLQVATDK DNGILLYKGD
1210 1220 1230 1240 1250
NDPLALELYQ GHVRLVYDSL SSPPTTVYSV ETVNDGQFHS VELVMLNQTL
1260 1270 1280 1290 1300
NLVVDKGAPK SLGKLQKQPA VGSNSPLYLG GIPTSTGLSA LRQGADRPLG
1310 1320 1330 1340 1350
GFHGCIHEVR INNELQDFKA LPPQSLGVSP GCKSCTVCRH GLCRSVEKDS
1360 1370 1380 1390 1400
VVCECHPGWT GPLCDQEARD PCLGHSCRHG TCMATGDSYV CKCAEGYGGA
1410 1420 1430 1440 1450
LCDQKNDSAS ACSAFKCHHG QCHISDRGEP YCLCQPGFSG HHCEQENPCM
1460 1470 1480 1490 1500
GEIVREAIRR QKDYASCATA SKVPIMECRG GCGSQCCQPI RSKRRKYVFQ
1510 1520
CTDGSSFVEE VERHLECGCR ACS
Length:1,523
Mass (Da):167,727
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95C4E98E58B9C8EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti582G → S in AAD44760 (PubMed:10433822).Curated1
Sequence conflicti606S → G in AAD44760 (PubMed:10433822).Curated1
Sequence conflicti729C → F in AAD44760 (PubMed:10433822).Curated1
Sequence conflicti999D → G in AAD44760 (PubMed:10433822).Curated1
Sequence conflicti1242E → K in AAD44760 (PubMed:10433822).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF144629 mRNA Translation: AAD44760.1
AL669839 Genomic DNA No translation available.
AL669856 Genomic DNA No translation available.
AL731688 Genomic DNA No translation available.
AL732401 Genomic DNA No translation available.
AL732630 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS24542.1

NCBI Reference Sequences

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RefSeqi
NP_035542.2, NM_011412.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000069837; ENSMUSP00000066857; ENSMUSG00000056427

Database of genes from NCBI RefSeq genomes

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GeneIDi
20564

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20564

UCSC genome browser

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UCSCi
uc007ild.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144629 mRNA Translation: AAD44760.1
AL669839 Genomic DNA No translation available.
AL669856 Genomic DNA No translation available.
AL731688 Genomic DNA No translation available.
AL732401 Genomic DNA No translation available.
AL732630 Genomic DNA No translation available.
CCDSiCCDS24542.1
RefSeqiNP_035542.2, NM_011412.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi203329, 3 interactors
STRINGi10090.ENSMUSP00000066857

PTM databases

GlyConnecti2717
PhosphoSitePlusiQ9WVB4

Proteomic databases

MaxQBiQ9WVB4
PaxDbiQ9WVB4
PRIDEiQ9WVB4

Genome annotation databases

EnsembliENSMUST00000069837; ENSMUSP00000066857; ENSMUSG00000056427
GeneIDi20564
KEGGimmu:20564
UCSCiuc007ild.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6586
MGIiMGI:1315202 Slit3

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000159322
HOGENOMiHOG000116120
InParanoidiQ9WVB4
KOiK06850
OMAiSVHGRMF
OrthoDBi28488at2759
TreeFamiTF332887

Enzyme and pathway databases

ReactomeiR-MMU-376176 Signaling by ROBO receptors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Slit3 mouse

Protein Ontology

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PROi
PR:Q9WVB4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000056427 Expressed in 239 organ(s), highest expression level in dorsal pancreas
GenevisibleiQ9WVB4 MM

Family and domain databases

Gene3Di3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 2 hits
PF02210 Laminin_G_2, 1 hit
PF13855 LRR_8, 5 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 3 hits
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 9 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 18 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLIT3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WVB4
Secondary accession number(s): B1ATW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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