Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transducin-like enhancer protein 2

Gene

Tle2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).By similarity

GO - Molecular functioni

  • repressing transcription factor binding Source: GO_Central
  • transcription corepressor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex
R-MMU-4641265 Repression of WNT target genes

Names & Taxonomyi

Protein namesi
Recommended name:
Transducin-like enhancer protein 2
Gene namesi
Name:Tle2
Synonyms:Grg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:104635 Tle2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512791 – 767Transducin-like enhancer protein 2Add BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253Phosphoserine; by CK2Sequence analysis1
Modified residuei274Phosphoserine; by CDK1Sequence analysis1
Modified residuei278Phosphothreonine; by CDK1Sequence analysis1
Modified residuei306PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by XIAP/BIRC4.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9WVB2
PaxDbiQ9WVB2
PeptideAtlasiQ9WVB2
PRIDEiQ9WVB2

PTM databases

iPTMnetiQ9WVB2
PhosphoSitePlusiQ9WVB2

Expressioni

Gene expression databases

BgeeiENSMUSG00000034771 Expressed in 219 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ9WVB2 baseline and differential
GenevisibleiQ9WVB2 MM

Interactioni

Subunit structurei

Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121125

Structurei

3D structure databases

ProteinModelPortaliQ9WVB2
SMRiQ9WVB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati479 – 517WD 1Add BLAST39
Repeati525 – 564WD 2Add BLAST40
Repeati569 – 608WD 3Add BLAST40
Repeati611 – 650WD 4Add BLAST40
Repeati693 – 732WD 5Add BLAST40
Repeati734 – 766WD 6Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 152Q domainBy similarityAdd BLAST152
Regioni153 – 215GP domainBy similarityAdd BLAST63
Regioni216 – 279CcN domainBy similarityAdd BLAST64
Regioni280 – 447SP domainBy similarityAdd BLAST168

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi238 – 242Nuclear localization signalSequence analysis5

Domaini

WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.1 Publication

Sequence similaritiesi

Belongs to the WD repeat Groucho/TLE family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
GeneTreeiENSGT00550000074465
HOGENOMiHOG000293211
HOVERGENiHBG004689
InParanoidiQ9WVB2
OMAiAPICVPA
OrthoDBiEOG091G181Y
PhylomeDBiQ9WVB2
TreeFamiTF314167

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10814 PTHR10814, 1 hit
PfamiView protein in Pfam
PF03920 TLE_N, 2 hits
PF00400 WD40, 3 hits
PRINTSiPR01850 GROUCHOFAMLY
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9WVB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYPQGRHPTP LQSGQPFKFS VLEICDRIKE EFQFLQAQYH SLKLECEKLA
60 70 80 90 100
SEKTEMQRHY VMAAPHQCPQ GGTSYPHWPR LSPLQYYEMS YGLNIEMHKQ
110 120 130 140 150
AEIVKRLSAI CAQMVPFLTQ EHQQQVLQAV DRAKQVTVGE LNSLLGQQNQ
160 170 180 190 200
LQPLSHAPPV PLTPRPAGLV GAGATGLLAL SGALAAQAQL VAAVKEDRVG
210 220 230 240 250
VDAEGSRVDR AASRSSSPSP PESLVEEDHP SSRGGSGKQQ RAEDKDLSGP
260 270 280 290 300
YDSEEDKSDY NLVVDEDQPS EPPSPVTTPC GKAPLCIPAR RDLTDSPASL
310 320 330 340 350
ASSLGSPLPR SKDIALNDLP TGTPASRSCG TSPPQDSSTP GPSSASHLCQ
360 370 380 390 400
LAAQPAAPTD SIALRSPLTL SSPFTSSFSL GSHSTLNGDL SMPGSYVGLH
410 420 430 440 450
LSPQVSSSVV YGRSPLQMAF ESHPHLRGSS VSLPGIPVAK PAYSFHVSAD
460 470 480 490 500
GQMQPVPFPS DALVGTGIPR HARQLHTLAH GEVVCAVTIS SSTQHVYTGG
510 520 530 540 550
KGCVKVWDVG QPGSKTPVAQ LDCLNRDNYI RSCKLLPDGQ SLIVGGEAST
560 570 580 590 600
LSIWDLAAPT PRIKAELTSS APACYALAVS PDAKVCFSCC SDGNIVVWDL
610 620 630 640 650
QNQAMVRQFQ GHTDGASCID ISDYGTRLWT GGLDNTVRCW DLREGRQLQQ
660 670 680 690 700
HDFSSQIFSL GHCPNQDWLA VGMESSHVEV LHVRKPEKYQ LRLHESCVLS
710 720 730 740 750
LKFASCGRWF VSTGKDNLLN AWRTPYGASI FQSKESSSVL SCDISRNNKY
760
IVTGSGDKKA TVYEVVY
Length:767
Mass (Da):82,623
Last modified:November 1, 1999 - v1
Checksum:i2BECE931EE993C44
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UN01Q3UN01_MOUSE
Transducin-like enhancer protein 2
Tle2
732Annotation score:
E9PV07E9PV07_MOUSE
Transducin-like enhancer protein 2
Tle2
736Annotation score:
F6YM15F6YM15_MOUSE
Transducin-like enhancer protein 2
Tle2
119Annotation score:
F6X5U5F6X5U5_MOUSE
Transducin-like enhancer protein 2
Tle2
134Annotation score:
D3Z1A4D3Z1A4_MOUSE
Transducin-like enhancer protein 2
Tle2
153Annotation score:
D3Z2J7D3Z2J7_MOUSE
Transducin-like enhancer protein 2
Tle2
121Annotation score:
D3Z0X0D3Z0X0_MOUSE
Transducin-like enhancer protein 2
Tle2
17Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145958 mRNA Translation: AAD37694.1
CCDSiCCDS24063.1
RefSeqiNP_062699.1, NM_019725.2
XP_006513647.1, XM_006513584.2
UniGeneiMm.38608

Genome annotation databases

EnsembliENSMUST00000146358; ENSMUSP00000121125; ENSMUSG00000034771
GeneIDi21886
KEGGimmu:21886
UCSCiuc007gis.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145958 mRNA Translation: AAD37694.1
CCDSiCCDS24063.1
RefSeqiNP_062699.1, NM_019725.2
XP_006513647.1, XM_006513584.2
UniGeneiMm.38608

3D structure databases

ProteinModelPortaliQ9WVB2
SMRiQ9WVB2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121125

PTM databases

iPTMnetiQ9WVB2
PhosphoSitePlusiQ9WVB2

Proteomic databases

MaxQBiQ9WVB2
PaxDbiQ9WVB2
PeptideAtlasiQ9WVB2
PRIDEiQ9WVB2

Protocols and materials databases

DNASUi21886
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000146358; ENSMUSP00000121125; ENSMUSG00000034771
GeneIDi21886
KEGGimmu:21886
UCSCiuc007gis.2 mouse

Organism-specific databases

CTDi7089
MGIiMGI:104635 Tle2

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
GeneTreeiENSGT00550000074465
HOGENOMiHOG000293211
HOVERGENiHBG004689
InParanoidiQ9WVB2
OMAiAPICVPA
OrthoDBiEOG091G181Y
PhylomeDBiQ9WVB2
TreeFamiTF314167

Enzyme and pathway databases

ReactomeiR-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex
R-MMU-4641265 Repression of WNT target genes

Miscellaneous databases

PROiPR:Q9WVB2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034771 Expressed in 219 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ9WVB2 baseline and differential
GenevisibleiQ9WVB2 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10814 PTHR10814, 1 hit
PfamiView protein in Pfam
PF03920 TLE_N, 2 hits
PF00400 WD40, 3 hits
PRINTSiPR01850 GROUCHOFAMLY
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTLE2_MOUSE
AccessioniPrimary (citable) accession number: Q9WVB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again