Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat and SOCS box protein 1

Gene

Asb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in testis development. Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • male genitalia development Source: MGI
  • protein ubiquitination Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 1
Short name:
ASB-1
Gene namesi
Name:Asb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1929735 Asb1

Subcellular locationi

Pathology & Biotechi

Disruption phenotypei

Decreased spermatogenesis with less complete filling of seminiferous tubules but fertility does not appear to be affected.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669241 – 336Ankyrin repeat and SOCS box protein 1Add BLAST336

Proteomic databases

MaxQBiQ9WV74
PaxDbiQ9WV74
PRIDEiQ9WV74

PTM databases

PhosphoSitePlusiQ9WV74

Expressioni

Tissue specificityi

Highest expression in testis, spleen, bone marrow and salivary gland.2 Publications

Gene expression databases

BgeeiENSMUSG00000026311 Expressed in 224 organ(s), highest expression level in blood
CleanExiMM_ASB1
ExpressionAtlasiQ9WV74 baseline and differential
GenevisibleiQ9WV74 MM

Interactioni

Subunit structurei

Interacts with CUL5 and RNF7.By similarity

Protein-protein interaction databases

BioGridi211142, 2 interactors
STRINGi10090.ENSMUSP00000027538

Structurei

3D structure databases

ProteinModelPortaliQ9WV74
SMRiQ9WV74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 69ANK 1Add BLAST33
Repeati78 – 107ANK 2Add BLAST30
Repeati111 – 140ANK 3Add BLAST30
Repeati144 – 173ANK 4Add BLAST30
Repeati192 – 221ANK 5Add BLAST30
Repeati236 – 266ANK 6Add BLAST31
Domaini287 – 336SOCS boxPROSITE-ProRule annotationAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150865
HOVERGENiHBG107089
InParanoidiQ9WV74
KOiK10323
OrthoDBiEOG091G090M
PhylomeDBiQ9WV74
TreeFamiTF331945

Family and domain databases

CDDicd00204 ANK, 1 hit
cd03720 SOCS_ASB1, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037331 ASB1_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50225 SOCS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9WV74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEGGTGPDG RAGPGPAGPN LKEWLREQFC DHPLEHCDDT RLHDAAYVGD
60 70 80 90 100
LQTLRNLLQE ESYRSRINEK SVWCCGWLPC TPLRIAATAG HGNCVDFLIR
110 120 130 140 150
KGAEVDLVDV KGQTALYVAV VNGHLESTEI LLEAGADPNG SRHHRSTPVY
160 170 180 190 200
HASRVGRDDI LKALIRYGAD VDVNHHLTPD TRPPFSRRLT SLVVCPLYIS
210 220 230 240 250
AAYHNLQCFR LLLQAGANPD FNCNGPVNTQ EFYRGSPGCV MDAVLRHGCE
260 270 280 290 300
AAFVSLLVEF GANLNLVKWE SLGPEARGRR KMDPEALQVF KEARSIPRTL
310 320 330
LSLCRVAVRR ALGKYRLHLV PSLPLPDPIK KFLLYE
Length:336
Mass (Da):37,232
Last modified:November 1, 1999 - v1
Checksum:i966119E1B21A5E4F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9J5G3X9J5_MOUSE
Ankyrin repeat and SOCS box protein...
Asb1 mCG_12877
328Annotation score:
A0A0A0MQ78A0A0A0MQ78_MOUSE
Ankyrin repeat and SOCS box protein...
Asb1 mCG_12877
96Annotation score:
A0A087WQE9A0A087WQE9_MOUSE
Ankyrin repeat and SOCS box protein...
Asb1 mCG_12877
301Annotation score:
S4W6L8S4W6L8_MOUSE
Ankyrin repeat and SOCS box protein...
Asb1
218Annotation score:
S4W2P0S4W2P0_MOUSE
Ankyrin repeat and SOCS box protein...
Asb1
89Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155352 mRNA Translation: AAD38808.1
CCDSiCCDS35665.1
RefSeqiNP_001034215.1, NM_001039126.2
UniGeneiMm.234152

Genome annotation databases

EnsembliENSMUST00000086843; ENSMUSP00000084054; ENSMUSG00000026311
GeneIDi65247
KEGGimmu:65247
UCSCiuc007caz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155352 mRNA Translation: AAD38808.1
CCDSiCCDS35665.1
RefSeqiNP_001034215.1, NM_001039126.2
UniGeneiMm.234152

3D structure databases

ProteinModelPortaliQ9WV74
SMRiQ9WV74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211142, 2 interactors
STRINGi10090.ENSMUSP00000027538

PTM databases

PhosphoSitePlusiQ9WV74

Proteomic databases

MaxQBiQ9WV74
PaxDbiQ9WV74
PRIDEiQ9WV74

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086843; ENSMUSP00000084054; ENSMUSG00000026311
GeneIDi65247
KEGGimmu:65247
UCSCiuc007caz.1 mouse

Organism-specific databases

CTDi51665
MGIiMGI:1929735 Asb1

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150865
HOVERGENiHBG107089
InParanoidiQ9WV74
KOiK10323
OrthoDBiEOG091G090M
PhylomeDBiQ9WV74
TreeFamiTF331945

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q9WV74
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026311 Expressed in 224 organ(s), highest expression level in blood
CleanExiMM_ASB1
ExpressionAtlasiQ9WV74 baseline and differential
GenevisibleiQ9WV74 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
cd03720 SOCS_ASB1, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037331 ASB1_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASB1_MOUSE
AccessioniPrimary (citable) accession number: Q9WV74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again