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Protein

Ankyrin repeat and SOCS box protein 3

Gene

Asb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 3
Short name:
ASB-3
Gene namesi
Name:Asb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1929749 Asb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669271 – 525Ankyrin repeat and SOCS box protein 3Add BLAST525

Proteomic databases

MaxQBiQ9WV72
PaxDbiQ9WV72
PRIDEiQ9WV72

PTM databases

iPTMnetiQ9WV72
PhosphoSitePlusiQ9WV72

Expressioni

Tissue specificityi

Widely expressed; highest expression in testis and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000020305 Expressed in 267 organ(s), highest expression level in blood
CleanExiMM_ASB3
ExpressionAtlasiQ9WV72 baseline and differential
GenevisibleiQ9WV72 MM

Interactioni

Subunit structurei

Interacts with ELOB and TNFRSF1B.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211146, 2 interactors
STRINGi10090.ENSMUSP00000020551

Structurei

3D structure databases

ProteinModelPortaliQ9WV72
SMRiQ9WV72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 38ANK 1Add BLAST30
Repeati42 – 71ANK 2Add BLAST30
Repeati78 – 107ANK 3Add BLAST30
Repeati111 – 140ANK 4Add BLAST30
Repeati145 – 174ANK 5Add BLAST30
Repeati178 – 207ANK 6Add BLAST30
Repeati211 – 240ANK 7Add BLAST30
Repeati246 – 275ANK 8Add BLAST30
Repeati279 – 308ANK 9Add BLAST30
Repeati315 – 346ANK 10Add BLAST32
Domaini442 – 505SOCS boxPROSITE-ProRule annotationAdd BLAST64

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148951
HOGENOMiHOG000022587
HOVERGENiHBG024356
InParanoidiQ9WV72
KOiK10325
OrthoDBiEOG091G03ZR
TreeFamiTF315127

Family and domain databases

CDDicd00204 ANK, 3 hits
cd03722 SOCS_ASB3, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037329 ASB3_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF13606 Ank_3, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 10 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50225 SOCS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9WV72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFTEAYSDT CSTVGLAARE GNVKILRKLL KKGRSVDVAD NRGWMPIHEA
60 70 80 90 100
AYHNAVECLQ MLIHTDSSEN YIKAKTFEGF CALHLAVSQG HWKITQILLE
110 120 130 140 150
AGADPNETTL EETTPLFLAV ESGRIDVLKL LLQHGANVNG SHSMSGWNSL
160 170 180 190 200
HQASFQGNAE TIRLLLKQGA DRECQDDFGI TPLFVAAQYG KLESMSILIS
210 220 230 240 250
SGANVNCQAL DKATPLFIAA QEGHTKCVEL LLSSGADPDL YCNEDNWQLP
260 270 280 290 300
IHAAAQMGHT ETLDLLIPRT NRACDTGPDK VSPVYSAVFG GREECLEMLL
310 320 330 340 350
QNGYSPDAQM CLVFGFSSPL CMAFQKDCDF SGIVNILLKY GAQLNELHLA
360 370 380 390 400
YCLKYEKFSM FCSFLKKGSL MVPWNHTSEF ISYAVKAQTK YKAWLPHLLL
410 420 430 440 450
AGFDPLILLC SSSWVDSASD DILIFTLEFS NWKRLPSAVE KMLSVRANSS
460 470 480 490 500
WALQQHLASV PSLTHLCRLE IRASLKAEHL HSDIFIHQLP LPRSLQNYLL
510 520
YEEVLRMNEI LEPAANQDGE TSKAT
Length:525
Mass (Da):58,283
Last modified:July 27, 2011 - v2
Checksum:iDEFCAC73EE2AF5E7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SV07A0A0N4SV07_MOUSE
Ankyrin repeat and SOCS box protein...
Asb3
564Annotation score:
A8Y5I6A8Y5I6_MOUSE
Ankyrin repeat and SOCS box protein...
Asb3
463Annotation score:
D6RDR7D6RDR7_MOUSE
Ankyrin repeat and SOCS box protein...
Asb3
124Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163R → K in AAD38810 (PubMed:11111040).Curated1
Sequence conflicti277G → E in AAD38810 (PubMed:11111040).Curated1
Sequence conflicti418A → V in AAD38810 (PubMed:11111040).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155354 mRNA Translation: AAD38810.1
AK143580 mRNA Translation: BAE25448.1
AL646095, AL662891, AL732621 Genomic DNA Translation: CAI24293.1
AL662891, AL646095, AL732621 Genomic DNA Translation: CAI24539.1
AL732621, AL646095, AL662891 Genomic DNA Translation: CAI25026.1
CCDSiCCDS24511.1
RefSeqiNP_076395.2, NM_023906.3
XP_006514834.1, XM_006514771.3
UniGeneiMm.440539

Genome annotation databases

EnsembliENSMUST00000020551; ENSMUSP00000020551; ENSMUSG00000020305
GeneIDi65257
KEGGimmu:65257
UCSCiuc007iif.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155354 mRNA Translation: AAD38810.1
AK143580 mRNA Translation: BAE25448.1
AL646095, AL662891, AL732621 Genomic DNA Translation: CAI24293.1
AL662891, AL646095, AL732621 Genomic DNA Translation: CAI24539.1
AL732621, AL646095, AL662891 Genomic DNA Translation: CAI25026.1
CCDSiCCDS24511.1
RefSeqiNP_076395.2, NM_023906.3
XP_006514834.1, XM_006514771.3
UniGeneiMm.440539

3D structure databases

ProteinModelPortaliQ9WV72
SMRiQ9WV72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211146, 2 interactors
STRINGi10090.ENSMUSP00000020551

PTM databases

iPTMnetiQ9WV72
PhosphoSitePlusiQ9WV72

Proteomic databases

MaxQBiQ9WV72
PaxDbiQ9WV72
PRIDEiQ9WV72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020551; ENSMUSP00000020551; ENSMUSG00000020305
GeneIDi65257
KEGGimmu:65257
UCSCiuc007iif.1 mouse

Organism-specific databases

CTDi51130
MGIiMGI:1929749 Asb3

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148951
HOGENOMiHOG000022587
HOVERGENiHBG024356
InParanoidiQ9WV72
KOiK10325
OrthoDBiEOG091G03ZR
TreeFamiTF315127

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiAsb3 mouse
PROiPR:Q9WV72
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020305 Expressed in 267 organ(s), highest expression level in blood
CleanExiMM_ASB3
ExpressionAtlasiQ9WV72 baseline and differential
GenevisibleiQ9WV72 MM

Family and domain databases

CDDicd00204 ANK, 3 hits
cd03722 SOCS_ASB3, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037329 ASB3_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF13606 Ank_3, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 10 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASB3_MOUSE
AccessioniPrimary (citable) accession number: Q9WV72
Secondary accession number(s): Q5SSV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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