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Protein

Nucleolar complex protein 2 homolog

Gene

Noc2l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex protein 2 homolog
Short name:
Protein NOC2 homolog
Alternative name(s):
NOC2-like protein
Novel INHAT repressor
Gene namesi
Name:Noc2l
Synonyms:Nir
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1931051 Noc2l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210491 – 747Nucleolar complex protein 2 homologAdd BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95PhosphoserineBy similarity1
Modified residuei673PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei744PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WV70
MaxQBiQ9WV70
PaxDbiQ9WV70
PeptideAtlasiQ9WV70
PRIDEiQ9WV70

PTM databases

iPTMnetiQ9WV70
PhosphoSitePlusiQ9WV70

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Developmental stagei

Expressed during embryogenesis between 8.5 and 18.5 dpc.1 Publication

Interactioni

Subunit structurei

Interacts with p53/TP53. Interacts (via the N- and C-terminus domains) with AURKB (via the middle kinase domain). Interacts with TP63 (via activation domain). Interacts with histone H3 (via N-terminus and non-acetylated form preferentially). Associates with core histones and nucleosomes (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137253

Structurei

3D structure databases

ProteinModelPortaliQ9WV70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi639 – 747Asp/Glu-rich (acidic)Add BLAST109

Sequence similaritiesi

Belongs to the NOC2 family.Curated

Phylogenomic databases

eggNOGiKOG2256 Eukaryota
COG5604 LUCA
HOVERGENiHBG029261
InParanoidiQ9WV70

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR005343 Noc2
PANTHERiPTHR12687 PTHR12687, 1 hit
PfamiView protein in Pfam
PF03715 Noc2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9WV70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASRAPRRR LEDLSVDEFL ASGFESGSES ELEGAAEERR ARGAAWNRER
60 70 80 90 100
RGARTSPGPA GRLRKGRASE HKDQLSRLKD RDPEFYKFLQ ENDRSLLDFS
110 120 130 140 150
DSDSSAEEEE PFHSLPDTLE EASETEEDGG EDSDALPRGL RSKKNEPVPV
160 170 180 190 200
TLAMVERWRQ GSRHHLTPRL FHEVVQAFRA AVATTQGEQE AAETCRFQVA
210 220 230 240 250
DSAVFNALVT FCIRDLCGCL QKLLFGKTPK DSNRLLLPSS SPLWGKLRVD
260 270 280 290 300
VKSYLSAVVQ LAACLAEATV SAAVLQHISS LVPYFLTFPK QCRMLLKRMV
310 320 330 340 350
VLWSTGEESL RVLAFLVLIR VCRHKKEAFL GPILKQMYIM YVRNCKFTSP
360 370 380 390 400
STLPLISFMQ RTLTEMLALD PSVSYQHAFL YIRQLAVHLR NAMTTGKKET
410 420 430 440 450
HQSVYNWQYV HCLYLWCRVL STLGSSEILQ PLLYPLSQII IGCIKLLPTA
460 470 480 490 500
RFYPLRMHCV RALTLLSQTI GTFIPVLPFI LEIFQQVDFN RRPGRMSSKP
510 520 530 540 550
INFSVILKLS STNLQEKAYR DGLLEQLCDL ILEYLHSQAH SIAFPELVLP
560 570 580 590 600
TVLQLKSFLR ECKVANYCRQ VRQLLEKVQE NARHIESLRQ SATFSVSDRT
610 620 630 640 650
AVDAWEKQVR EEGTPLTRYY GHWKKLRDRE IQLEISGKER LEDLNFPEIK
660 670 680 690 700
RRKVEDRKDE DRKELKDLFE LDSSEGEDST DFFERGVPRL PEAHQGLKED
710 720 730 740
QEEEDKEEGD SDSEDGDTDT GVDLSELWQL AQGAQDELED LQLSEED
Length:747
Mass (Da):85,424
Last modified:September 19, 2002 - v2
Checksum:i1BC61817FC586C47
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QK52J3QK52_MOUSE
Nucleolar complex protein 2 homolog
Noc2l
750Annotation score:
Q8BHX6Q8BHX6_MOUSE
Nucleolar complex protein 2 homolog
Noc2l AF155546
593Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti531I → T in AAD38407 (Ref. 2) Curated1
Sequence conflicti586E → Q in AAD38407 (Ref. 2) Curated1
Sequence conflicti734A → P in AAD38407 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020013 mRNA Translation: AAH20013.1
AF155546 mRNA Translation: AAD38407.1
UniGeneiMm.423051
Mm.480639
Mm.486684

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020013 mRNA Translation: AAH20013.1
AF155546 mRNA Translation: AAD38407.1
UniGeneiMm.423051
Mm.480639
Mm.486684

3D structure databases

ProteinModelPortaliQ9WV70
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137253

PTM databases

iPTMnetiQ9WV70
PhosphoSitePlusiQ9WV70

Proteomic databases

EPDiQ9WV70
MaxQBiQ9WV70
PaxDbiQ9WV70
PeptideAtlasiQ9WV70
PRIDEiQ9WV70

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1931051 Noc2l

Phylogenomic databases

eggNOGiKOG2256 Eukaryota
COG5604 LUCA
HOVERGENiHBG029261
InParanoidiQ9WV70

Miscellaneous databases

PROiPR:Q9WV70
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR005343 Noc2
PANTHERiPTHR12687 PTHR12687, 1 hit
PfamiView protein in Pfam
PF03715 Noc2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOC2L_MOUSE
AccessioniPrimary (citable) accession number: Q9WV70
Secondary accession number(s): Q8VE16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 19, 2002
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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