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Entry version 180 (13 Feb 2019)
Sequence version 1 (01 Nov 1999)
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Protein

SH3 and multiple ankyrin repeat domains protein 1

Gene

Shank1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-6794361 Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 and multiple ankyrin repeat domains protein 1
Short name:
Shank1
Alternative name(s):
GKAP/SAPAP-interacting protein
SPANK-1
Somatostatin receptor-interacting protein
Short name:
SSTR-interacting protein
Short name:
SSTRIP
Synamon
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shank1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
621011 Shank1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001746721 – 2167SH3 and multiple ankyrin repeat domains protein 1Add BLAST2167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei43Omega-N-methylarginineBy similarity1
Modified residuei186PhosphotyrosineBy similarity1
Modified residuei540PhosphoserineCombined sources1
Modified residuei544Omega-N-methylarginineBy similarity1
Modified residuei671PhosphoserineBy similarity1
Modified residuei791PhosphoserineBy similarity1
Modified residuei898PhosphoserineCombined sources1
Modified residuei958Omega-N-methylarginineBy similarity1
Modified residuei1059Omega-N-methylarginineBy similarity1
Modified residuei1098Omega-N-methylarginineBy similarity1
Modified residuei1109Omega-N-methylarginineBy similarity1
Modified residuei1257Asymmetric dimethylarginineBy similarity1
Modified residuei1291PhosphoserineCombined sources1
Modified residuei1429Omega-N-methylarginineBy similarity1
Modified residuei1442PhosphoserineCombined sources1
Modified residuei1901Omega-N-methylarginineBy similarity1
Modified residuei2022Omega-N-methylarginineBy similarity1
Modified residuei2042Omega-N-methylarginineBy similarity1
Modified residuei2080Omega-N-methylarginineBy similarity1
Isoform 3 (identifier: Q9WV48-3)
Modified residuei638PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9WV48

PRoteomics IDEntifications database

More...
PRIDEi
Q9WV48

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9WV48

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WV48

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000019207 Expressed in 7 organ(s), highest expression level in brain

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9WV48 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May homomultimerize via its SAM domain. Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 (By similarity). Interacts with IGSF9. Interacts with HOMER1 and HOMER3 (PubMed:19345194).By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
249365, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9WV48

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9WV48

Protein interaction database and analysis system

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IntActi
Q9WV48, 17 interactors

Molecular INTeraction database

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MINTi
Q9WV48

STRING: functional protein association networks

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STRINGi
10116.ENSRNOP00000026100

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3OX-ray1.80A/B654-762[»]
1Q3PX-ray2.25A/B654-762[»]
3L4FX-ray2.80D653-765[»]
3QJMX-ray2.31A/B654-768[»]
3QJNX-ray2.71A/B/C/D/E/F/G/H654-768[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9WV48

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9WV48

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9WV48

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati195 – 210ANK 1Add BLAST16
Repeati212 – 245ANK 2Add BLAST34
Repeati246 – 278ANK 3Add BLAST33
Repeati279 – 312ANK 4Add BLAST34
Repeati313 – 345ANK 5Add BLAST33
Repeati346 – 378ANK 6Add BLAST33
Repeati379 – 395ANK 7Add BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini554 – 613SH3PROSITE-ProRule annotationAdd BLAST60
Domaini663 – 757PDZPROSITE-ProRule annotationAdd BLAST95
Domaini2104 – 2167SAMPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi929 – 932Poly-Pro4
Compositional biasi1010 – 1015Poly-His6
Compositional biasi1022 – 1027Poly-His6
Compositional biasi1194 – 1199Poly-Gly6
Compositional biasi1850 – 1860Poly-ProAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SHANK family.Curated

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
KOG4375 Eukaryota
COG0666 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153561

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000293276

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG079186

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9WV48

KEGG Orthology (KO)

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KOi
K15009

Identification of Orthologs from Complete Genome Data

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OMAi
TVHTHHY

Database of Orthologous Groups

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OrthoDBi
468249at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9WV48

Family and domain databases

Conserved Domains Database

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CDDi
cd00204 ANK, 2 hits
cd11982 SH3_Shank1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035735 Shank1_SH3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF00536 SAM_1, 1 hit
PF07653 SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM00228 PDZ, 1 hit
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50106 PDZ, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9WV48-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTHSPATSED EERHSASECP EGGSESDSSP DGPGRGPQGT RGRGSGAPGN
60 70 80 90 100
LASTRGLQGR SMSVPDDAHF SMMVFRIGIP DLHQTKCLRF NPDATIWTAK
110 120 130 140 150
QQVLCALSES LQDVLNYGLF QPATSGRDAN FLEEERLLRE YPQSFEKGVP
160 170 180 190 200
YLEFRYKTRV YKQTNLDEKQ LAKLHTKTGL KKFLEYVQLG TSDKVARLLD
210 220 230 240 250
KGLDPNYHDS DSGETPLTLA AQTEGSVEVI RTLCLGGAHI DFRARDGMTA
260 270 280 290 300
LHKAACARHC LALTALLDLG GSPNYKDRRG LTPLFHTAMV GGDPRCCELL
310 320 330 340 350
LYNRAQLGIA DENGWQEIHQ ACQRGHSQHL EHLLFYGAEP GAQNASGNTA
360 370 380 390 400
LHICALYNKE TCARILLYRG ANKDVKNNNG QTPFQVAVIA GNFELGELIR
410 420 430 440 450
NHREQDVVPF QESPKYAARR RGPPGAGLTV PPALLRANSD TSMALPDWMV
460 470 480 490 500
FSAPGASSSG TPGPTSGPQG QSQPSAPSTK LSSGTLRSAS SPRGARARSP
510 520 530 540 550
SRGRHPEDAK RQPRGRPSSS GTPRDGPAGG TGGSGGPGGS LGSRGRRRKL
560 570 580 590 600
YSAVPGRSFM AVKSYQAQGE GEISLSKGEK IKVLSIGEGG FWEGQVKGRV
610 620 630 640 650
GWFPSDCLEE VANRSQEGRQ ESRSDKAKRL FRHYTVGSYD SFDAPSLIDG
660 670 680 690 700
IDSGSDYIIK EKTVLLQKKD SEGFGFVLRG AKAQTPIEEF TPTPAFPALQ
710 720 730 740 750
YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNTLM
760 770 780 790 800
VKVVMVTRHP DMDEAVHKKA SQQAKRLPPP AISLRSKSMT SELEEMVSPW
810 820 830 840 850
KKKIEYEQQP AAVPSMEKKR TVYQMALNKL DEILAAAQQT ISASESPGPG
860 870 880 890 900
GLASLGKHRP KGFFATESSF DPHHRSQPSY DRPSFLPPGP GLMLRQKSIG
910 920 930 940 950
AAEDDRPYLA PPAMKFSRSL SVPGSEDIPP PPTTSPPEPP YSTPPAPSSS
960 970 980 990 1000
GRLTPSPRGG PFNPSSGGPL PASSPSSFDG PSPPDTRGGG REKSLYHSAA
1010 1020 1030 1040 1050
LPPAHHHPPH HHHHHAPPPQ PHHHHAHPPH PPEMETGGSP DDPPPRLALG
1060 1070 1080 1090 1100
PQPSLRGWRG GGPSPTSGAP SPSHHSSSGG SSGPTQAPAL RYFQLPPRAA
1110 1120 1130 1140 1150
SAAMYVPARS GRGRKGPLVK QTKVEGEPQK GSIPSASSPT SPALPRSEPP
1160 1170 1180 1190 1200
PAGPSEKNSI PIPTIIIKAP STSSSGRSSQ GSSTEAEPPT QPDGAGGGGS
1210 1220 1230 1240 1250
SPSPAPATSP VPPSPSPVPT PASPSGPATL DFTSQFGAAL VGAARREGGW
1260 1270 1280 1290 1300
QNEARRRSTL FLSTDAGDED GGDSGLGPGG PPGPRLRHSK SIDEGMFSAE
1310 1320 1330 1340 1350
PYLRLESGGS SGGYGAYAAG SRAYGGSGSS SAFTSFLPPR PLVHPLTGKA
1360 1370 1380 1390 1400
LDPASPLGLA LAARERALKE SSEGGGTPQP PPRPPSPRYD APPPTLHHHS
1410 1420 1430 1440 1450
PHSPHSPHAR HEPVLRLWGD PARRELGYRA GLGSQEKALT ASPPAARRSL
1460 1470 1480 1490 1500
LHRLPPTAPG VGPLLLQLGP EPPTPHPGVS KAWRTAAPEE PERLPLHVRF
1510 1520 1530 1540 1550
LENCQARPPP AGTRGSSTED GPGVPPPSPR RVLPTSPTSP RGNEENGLPL
1560 1570 1580 1590 1600
LVLPPPAPSV DVDDGEFLFA EPLPPPLEFS NSFEKPESPL TPGPPHPLPD
1610 1620 1630 1640 1650
PPSPATPLPA APPPAVAAAP PTLDSTASSL TSYDSEVATL TQGAPAAPGD
1660 1670 1680 1690 1700
PPAPGPPAPA APAPPAPQPG PDPPPGTDSG IEEVDSRSSS DHPLETISSA
1710 1720 1730 1740 1750
STLSSLSAEG GGNTGGVAGG GAGVASGTEL LDTYVAYLDG QAFGGSGTPG
1760 1770 1780 1790 1800
PPYPPQLMTP SKLRGRALGT SGNLRPGPSG GLRDPVTPTS PTVSVTGAGT
1810 1820 1830 1840 1850
DGLLALSACP GPSTAGVAGG PVAVEPEVPP VPLPAASSLP RKLLPWEEGP
1860 1870 1880 1890 1900
GPPPPPLPGP LSQPQASALA TVKASIISEL SSKLQQFGGS STAGGALPWA
1910 1920 1930 1940 1950
RGGSGGSTDS HHGGASYIPE RTSSLQRQRL SEDSQTSLLS KPSSSIFQNW
1960 1970 1980 1990 2000
PKPPLPPLPT GSGVSSSTAA APGATSPSAS SASASTRHLQ GVEFEMRPPL
2010 2020 2030 2040 2050
LRRAPSPSLL PASDHKVSPA PRPSSLPILP SGPIYPGLFD IRSSPTGGAG
2060 2070 2080 2090 2100
GSTDPFAPVF VPPHPGISGG LGGALSGASR SLSPTRLLSL PPDKPFGAKP
2110 2120 2130 2140 2150
LGFWTKFDVA DWLEWLGLSE HRAQFLDHEI DGSHLPALTK EDYVDLGVTR
2160
VGHRMNIDRA LKFFLER
Length:2,167
Mass (Da):226,335
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F478B5A7B18BA86
GO
Isoform 2 (identifier: Q9WV48-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-614: Missing.
     615-654: SQEGRQESRS...PSLIDGIDSG → MALSAVGGGP...PRRRSVWYIY

Show »
Length:1,553
Mass (Da):159,899
Checksum:iB9B7E6A33E26DE48
GO
Isoform 3 (identifier: Q9WV48-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-654: Missing.

Show »
Length:2,158
Mass (Da):225,477
Checksum:iBF18578E26D6578C
GO
Isoform 4 (identifier: Q9WV48-4) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     797-804: Missing.

Show »
Length:2,159
Mass (Da):225,368
Checksum:i912C1737EC330CB1
GO
Isoform 5 (identifier: Q9WV48-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1930-1943: LSEDSQTSLLSKPS → QYRIVVKSSDFGDF
     1944-2167: Missing.

Show »
Length:1,943
Mass (Da):202,919
Checksum:iD290DD45558B73AF
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD29417 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF02498 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1141S → T in AAD04569 (PubMed:10488079).Curated1
Sequence conflicti1174S → N in AAD29417 (PubMed:10433268).Curated1
Sequence conflicti1246R → K in AAD04569 (PubMed:10488079).Curated1
Sequence conflicti1323A → T in AAD04569 (PubMed:10488079).Curated1
Sequence conflicti1331S → D in AAD04569 (PubMed:10488079).Curated1
Sequence conflicti1726S → N in AAD29417 (PubMed:10433268).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0060721 – 614Missing in isoform 2. CuratedAdd BLAST614
Alternative sequenceiVSP_006073615 – 654SQEGR…GIDSG → MALSAVGGGPGGGALPQPPP ALSSSWPALGPRRRSVWYIY in isoform 2. CuratedAdd BLAST40
Alternative sequenceiVSP_006074646 – 654Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_006075797 – 804Missing in isoform 4. 1 Publication8
Alternative sequenceiVSP_0060761930 – 1943LSEDS…LSKPS → QYRIVVKSSDFGDF in isoform 5. CuratedAdd BLAST14
Alternative sequenceiVSP_0060771944 – 2167Missing in isoform 5. CuratedAdd BLAST224

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF102855 mRNA Translation: AAD04569.2
AF131951 mRNA Translation: AAD29417.1 Different initiation.
AF159046 mRNA Translation: AAD42975.1
AF141904 mRNA Translation: AAF02498.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_113939.2, NM_031751.3 [Q9WV48-1]
XP_017445247.1, XM_017589758.1 [Q9WV48-1]
XP_017445248.1, XM_017589759.1 [Q9WV48-4]
XP_017445249.1, XM_017589760.1 [Q9WV48-3]
XP_017445250.1, XM_017589761.1 [Q9WV48-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Rn.225968

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000026100; ENSRNOP00000026100; ENSRNOG00000019207 [Q9WV48-1]
ENSRNOT00000044257; ENSRNOP00000039860; ENSRNOG00000019207 [Q9WV48-3]
ENSRNOT00000092327; ENSRNOP00000075838; ENSRNOG00000019207 [Q9WV48-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
78957

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:78957

UCSC genome browser

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UCSCi
RGD:621011 rat [Q9WV48-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102855 mRNA Translation: AAD04569.2
AF131951 mRNA Translation: AAD29417.1 Different initiation.
AF159046 mRNA Translation: AAD42975.1
AF141904 mRNA Translation: AAF02498.1 Different initiation.
RefSeqiNP_113939.2, NM_031751.3 [Q9WV48-1]
XP_017445247.1, XM_017589758.1 [Q9WV48-1]
XP_017445248.1, XM_017589759.1 [Q9WV48-4]
XP_017445249.1, XM_017589760.1 [Q9WV48-3]
XP_017445250.1, XM_017589761.1 [Q9WV48-5]
UniGeneiRn.225968

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3OX-ray1.80A/B654-762[»]
1Q3PX-ray2.25A/B654-762[»]
3L4FX-ray2.80D653-765[»]
3QJMX-ray2.31A/B654-768[»]
3QJNX-ray2.71A/B/C/D/E/F/G/H654-768[»]
ProteinModelPortaliQ9WV48
SMRiQ9WV48
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249365, 6 interactors
CORUMiQ9WV48
ELMiQ9WV48
IntActiQ9WV48, 17 interactors
MINTiQ9WV48
STRINGi10116.ENSRNOP00000026100

PTM databases

iPTMnetiQ9WV48
PhosphoSitePlusiQ9WV48

Proteomic databases

PaxDbiQ9WV48
PRIDEiQ9WV48

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026100; ENSRNOP00000026100; ENSRNOG00000019207 [Q9WV48-1]
ENSRNOT00000044257; ENSRNOP00000039860; ENSRNOG00000019207 [Q9WV48-3]
ENSRNOT00000092327; ENSRNOP00000075838; ENSRNOG00000019207 [Q9WV48-4]
GeneIDi78957
KEGGirno:78957
UCSCiRGD:621011 rat [Q9WV48-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50944
RGDi621011 Shank1

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4375 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000153561
HOGENOMiHOG000293276
HOVERGENiHBG079186
InParanoidiQ9WV48
KOiK15009
OMAiTVHTHHY
OrthoDBi468249at2759
PhylomeDBiQ9WV48

Enzyme and pathway databases

ReactomeiR-RNO-6794361 Neurexins and neuroligins

Miscellaneous databases

EvolutionaryTraceiQ9WV48

Protein Ontology

More...
PROi
PR:Q9WV48

Gene expression databases

BgeeiENSRNOG00000019207 Expressed in 7 organ(s), highest expression level in brain
GenevisibleiQ9WV48 RN

Family and domain databases

CDDicd00204 ANK, 2 hits
cd11982 SH3_Shank1, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035735 Shank1_SH3
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF00536 SAM_1, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00228 PDZ, 1 hit
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS50106 PDZ, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHAN1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WV48
Secondary accession number(s): Q9QZZ8, Q9WU13, Q9WUE8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: February 13, 2019
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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