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Protein

C->U-editing enzyme APOBEC-2

Gene

Apobec2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.By similarity

Catalytic activityi

Cytosine(6666) in apolipoprotein B mRNA + H2O = uracil(6666) in apolipoprotein B mRNA + NH3.

Cofactori

Zn2+By similarityNote: Binds 1 Zn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc; catalyticBy similarity1
Metal bindingi98Zinc; catalyticBy similarity1
Active sitei100Proton donorBy similarity1
Metal bindingi128Zinc; catalyticBy similarity1
Metal bindingi131Zinc; catalyticBy similarity1

GO - Molecular functioni

  • cytidine deaminase activity Source: MGI
  • identical protein binding Source: MGI
  • RNA binding Source: GO_Central
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cytidine to uridine editing Source: MGI
  • DNA demethylation Source: UniProtKB
  • mRNA modification Source: MGI
  • mRNA processing Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processmRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-72200 mRNA Editing: C to U Conversion
R-MMU-75094 Formation of the Editosome

Names & Taxonomyi

Protein namesi
Recommended name:
C->U-editing enzyme APOBEC-2 (EC:3.5.4.36)
Alternative name(s):
mRNA(cytosine(6666)) deaminase 2
Gene namesi
Name:Apobec2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1343178 Apobec2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001717501 – 224C->U-editing enzyme APOBEC-2Add BLAST224

Proteomic databases

MaxQBiQ9WV35
PaxDbiQ9WV35
PeptideAtlasiQ9WV35
PRIDEiQ9WV35

PTM databases

iPTMnetiQ9WV35
PhosphoSitePlusiQ9WV35

Expressioni

Tissue specificityi

Expressed exclusively in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000040694 Expressed in 146 organ(s), highest expression level in triceps surae
CleanExiMM_APOBEC2
GenevisibleiQ9WV35 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WV35, 1 interactor
MINTiQ9WV35
STRINGi10090.ENSMUSP00000047402

Structurei

Secondary structure

1224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9WV35
SMRiQ9WV35
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WV35

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 169CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IX13 Eukaryota
ENOG4111K4B LUCA
GeneTreeiENSGT00530000062933
HOGENOMiHOG000033754
HOVERGENiHBG107155
InParanoidiQ9WV35
KOiK18772
OMAiDEHAGAH
OrthoDBiEOG091G0JNJ
PhylomeDBiQ9WV35
TreeFamiTF331356

Family and domain databases

InterProiView protein in InterPro
IPR013158 APOBEC_N
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
PfamiView protein in Pfam
PF08210 APOBEC_N, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WV35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQKEEAAEA AAPASQNGDD LENLEDPEKL KELIDLPPFE IVTGVRLPVN
60 70 80 90 100
FFKFQFRNVE YSSGRNKTFL CYVVEVQSKG GQAQATQGYL EDEHAGAHAE
110 120 130 140 150
EAFFNTILPA FDPALKYNVT WYVSSSPCAA CADRILKTLS KTKNLRLLIL
160 170 180 190 200
VSRLFMWEEP EVQAALKKLK EAGCKLRIMK PQDFEYIWQN FVEQEEGESK
210 220
AFEPWEDIQE NFLYYEEKLA DILK
Length:224
Mass (Da):25,660
Last modified:November 1, 1999 - v1
Checksum:i75F98BC2CF2EBE0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161699 mRNA Translation: AAD45361.1
BC027530 mRNA Translation: AAH27530.1
CCDSiCCDS28868.1
RefSeqiNP_033824.1, NM_009694.3
UniGeneiMm.281793

Genome annotation databases

EnsembliENSMUST00000046549; ENSMUSP00000047402; ENSMUSG00000040694
ENSMUST00000229603; ENSMUSP00000155264; ENSMUSG00000116086
GeneIDi11811
KEGGimmu:11811
UCSCiuc008cxx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161699 mRNA Translation: AAD45361.1
BC027530 mRNA Translation: AAH27530.1
CCDSiCCDS28868.1
RefSeqiNP_033824.1, NM_009694.3
UniGeneiMm.281793

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RPZNMR-A46-224[»]
ProteinModelPortaliQ9WV35
SMRiQ9WV35
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WV35, 1 interactor
MINTiQ9WV35
STRINGi10090.ENSMUSP00000047402

PTM databases

iPTMnetiQ9WV35
PhosphoSitePlusiQ9WV35

Proteomic databases

MaxQBiQ9WV35
PaxDbiQ9WV35
PeptideAtlasiQ9WV35
PRIDEiQ9WV35

Protocols and materials databases

DNASUi11811
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046549; ENSMUSP00000047402; ENSMUSG00000040694
ENSMUST00000229603; ENSMUSP00000155264; ENSMUSG00000116086
GeneIDi11811
KEGGimmu:11811
UCSCiuc008cxx.1 mouse

Organism-specific databases

CTDi10930
MGIiMGI:1343178 Apobec2

Phylogenomic databases

eggNOGiENOG410IX13 Eukaryota
ENOG4111K4B LUCA
GeneTreeiENSGT00530000062933
HOGENOMiHOG000033754
HOVERGENiHBG107155
InParanoidiQ9WV35
KOiK18772
OMAiDEHAGAH
OrthoDBiEOG091G0JNJ
PhylomeDBiQ9WV35
TreeFamiTF331356

Enzyme and pathway databases

ReactomeiR-MMU-72200 mRNA Editing: C to U Conversion
R-MMU-75094 Formation of the Editosome

Miscellaneous databases

EvolutionaryTraceiQ9WV35
PROiPR:Q9WV35
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040694 Expressed in 146 organ(s), highest expression level in triceps surae
CleanExiMM_APOBEC2
GenevisibleiQ9WV35 MM

Family and domain databases

InterProiView protein in InterPro
IPR013158 APOBEC_N
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
PfamiView protein in Pfam
PF08210 APOBEC_N, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABEC2_MOUSE
AccessioniPrimary (citable) accession number: Q9WV35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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