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Protein

Actin-related protein 2/3 complex subunit 1B

Gene

Arpc1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).By similarity

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • protein-containing complex binding Source: MGI
  • structural constituent of cytoskeleton Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1B
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:Arpc1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1343142 Arpc1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508561 – 372Actin-related protein 2/3 complex subunit 1BAdd BLAST372

Proteomic databases

EPDiQ9WV32
MaxQBiQ9WV32
PaxDbiQ9WV32
PRIDEiQ9WV32

PTM databases

iPTMnetiQ9WV32
PhosphoSitePlusiQ9WV32
SwissPalmiQ9WV32

Expressioni

Gene expression databases

BgeeiENSMUSG00000029622 Expressed in 150 organ(s), highest expression level in humerus cartilage element
CleanExiMM_ARPC1B
ExpressionAtlasiQ9WV32 baseline and differential
GenevisibleiQ9WV32 MM

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198208, 3 interactors
IntActiQ9WV32, 3 interactors
MINTiQ9WV32
STRINGi10090.ENSMUSP00000082822

Structurei

3D structure databases

ProteinModelPortaliQ9WV32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 45WD 1Add BLAST40
Repeati50 – 89WD 2Add BLAST40
Repeati94 – 135WD 3Add BLAST42
Repeati140 – 179WD 4Add BLAST40
Repeati242 – 280WD 5Add BLAST39
Repeati324 – 367WD 6Add BLAST44

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1523 Eukaryota
ENOG410XNWX LUCA
GeneTreeiENSGT00390000008339
HOGENOMiHOG000181752
HOVERGENiHBG050560
InParanoidiQ9WV32
KOiK05757
OMAiVLFTYDS
TreeFamiTF315041

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030141 ARC1B
IPR017383 ARPC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10709 PTHR10709, 1 hit
PTHR10709:SF10 PTHR10709:SF10, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PIRSFiPIRSF038093 ARP2/3_su1, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9WV32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWNKVHELKE
60 70 80 90 100
HNGQVTGIDW APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR
110 120 130 140 150
CVRWAPNENK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNNVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS
210 220 230 240 250
SCGWVHGVCF SASGSRVAWV SHDSTVCLVD ADKKMAVATL ASETLPLLAV
260 270 280 290 300
TFITENSLVA AGHDCFPVLF TYDNAAVTLS FGGRLDVPKQ SSQRGMTARE
310 320 330 340 350
RFQNLDKKAS SEGGAATGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM
360 370
DGGMSIWDVK SLESALKDLK IK
Length:372
Mass (Da):41,064
Last modified:July 27, 2011 - v4
Checksum:i0315BFB6E8697D89
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q91Z25Q91Z25_MOUSE
Actin-related protein 2/3 complex s...
Arpc1b
376Annotation score:
D3Z6S0D3Z6S0_MOUSE
Actin-related protein 2/3 complex s...
Arpc1b
56Annotation score:
F6VVE6F6VVE6_MOUSE
Actin-related protein 2/3 complex s...
Arpc1b
232Annotation score:
F6THG2F6THG2_MOUSE
Actin-related protein 2/3 complex s...
Arpc1b
105Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112A → R in AAD43352 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162768 mRNA Translation: AAD43352.1
AK002274 mRNA Translation: BAB21980.1
AK005378 mRNA Translation: BAB23985.1
AK147731 mRNA Translation: BAE28101.1
AK148145 mRNA Translation: BAE28373.1
AK159371 mRNA Translation: BAE35028.1
AK167978 mRNA Translation: BAE39970.1
AK168774 mRNA Translation: BAE40610.1
AK172124 mRNA Translation: BAE42835.1
CH466529 Genomic DNA Translation: EDL19001.1
CH466529 Genomic DNA Translation: EDL19002.1
BC003441 mRNA Translation: AAH03441.1
CCDSiCCDS19856.1
RefSeqiNP_075631.2, NM_023142.2
UniGeneiMm.30010

Genome annotation databases

EnsembliENSMUST00000085679; ENSMUSP00000082822; ENSMUSG00000029622
GeneIDi11867
KEGGimmu:11867
UCSCiuc009amb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162768 mRNA Translation: AAD43352.1
AK002274 mRNA Translation: BAB21980.1
AK005378 mRNA Translation: BAB23985.1
AK147731 mRNA Translation: BAE28101.1
AK148145 mRNA Translation: BAE28373.1
AK159371 mRNA Translation: BAE35028.1
AK167978 mRNA Translation: BAE39970.1
AK168774 mRNA Translation: BAE40610.1
AK172124 mRNA Translation: BAE42835.1
CH466529 Genomic DNA Translation: EDL19001.1
CH466529 Genomic DNA Translation: EDL19002.1
BC003441 mRNA Translation: AAH03441.1
CCDSiCCDS19856.1
RefSeqiNP_075631.2, NM_023142.2
UniGeneiMm.30010

3D structure databases

ProteinModelPortaliQ9WV32
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198208, 3 interactors
IntActiQ9WV32, 3 interactors
MINTiQ9WV32
STRINGi10090.ENSMUSP00000082822

PTM databases

iPTMnetiQ9WV32
PhosphoSitePlusiQ9WV32
SwissPalmiQ9WV32

Proteomic databases

EPDiQ9WV32
MaxQBiQ9WV32
PaxDbiQ9WV32
PRIDEiQ9WV32

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085679; ENSMUSP00000082822; ENSMUSG00000029622
GeneIDi11867
KEGGimmu:11867
UCSCiuc009amb.2 mouse

Organism-specific databases

CTDi10095
MGIiMGI:1343142 Arpc1b

Phylogenomic databases

eggNOGiKOG1523 Eukaryota
ENOG410XNWX LUCA
GeneTreeiENSGT00390000008339
HOGENOMiHOG000181752
HOVERGENiHBG050560
InParanoidiQ9WV32
KOiK05757
OMAiVLFTYDS
TreeFamiTF315041

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Miscellaneous databases

ChiTaRSiArpc1b mouse
PROiPR:Q9WV32
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029622 Expressed in 150 organ(s), highest expression level in humerus cartilage element
CleanExiMM_ARPC1B
ExpressionAtlasiQ9WV32 baseline and differential
GenevisibleiQ9WV32 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030141 ARC1B
IPR017383 ARPC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10709 PTHR10709, 1 hit
PTHR10709:SF10 PTHR10709:SF10, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PIRSFiPIRSF038093 ARP2/3_su1, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARC1B_MOUSE
AccessioniPrimary (citable) accession number: Q9WV32
Secondary accession number(s): Q9CRC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 144 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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