UniProtKB - Q9WV32 (ARC1B_MOUSE)

BLAST

>sp|Q9WV32|ARC1B_MOUSE Actin-related protein 2/3 complex subunit 1B OS=Mus musculus OX=10090 GN=Arpc1b PE=1 SV=4
MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWNKVHELKEHNGQVTGIDW
APESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVI
SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERP
APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLVDADKKMAVATL
ASETLPLLAVTFITENSLVAAGHDCFPVLFTYDNAAVTLSFGGRLDVPKQSSQRGMTARE
RFQNLDKKASSEGGAATGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVK
SLESALKDLKIK

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History
Entry version 144 (07 Nov 2018)
Sequence version 4 (27 Jul 2011)
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Protein

Actin-related protein 2/3 complex subunit 1B

Gene

Arpc1b

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).By similarity

GO - Molecular functionⁱ

actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-containing complex binding Source: MGI
structural constituent of cytoskeleton Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

Arp2/3 complex-mediated actin nucleation Source: MGI
response to estradiol Source: Ensembl
response to estrogen Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding

Molecular function

Actin-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation R-MMU-3928662 EPHB-mediated forward signaling R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Reactomeⁱ

R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Actin-related protein 2/3 complex subunit 1B Alternative name(s): Arp2/3 complex 41 kDa subunit p41-ARC
Gene namesⁱ	Name:Arpc1b
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1343142 Arpc1b

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050856	1 – 372	Actin-related protein 2/3 complex subunit 1BAdd BLAST		372

Proteomic databases

EPDⁱ	Q9WV32
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9WV32
PaxDbⁱ	Q9WV32
PRIDEⁱ	Q9WV32

PTM databases

iPTMnetⁱ	Q9WV32
PhosphoSitePlusⁱ	Q9WV32
SwissPalmⁱ	Q9WV32

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029622 Expressed in 150 organ(s), highest expression level in humerus cartilage element
CleanExⁱ	MM_ARPC1B
ExpressionAtlasⁱ	Q9WV32 baseline and differential
Genevisibleⁱ	Q9WV32 MM

Interactionⁱ

Subunit structureⁱ

Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functionⁱ

actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198208, 3 interactors
IntActⁱ	Q9WV32, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q9WV32
STRINGⁱ	10090.ENSMUSP00000082822

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9WV32
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	6 – 45	WD 1Add BLAST	40
Repeatⁱ	50 – 89	WD 2Add BLAST	40
Repeatⁱ	94 – 135	WD 3Add BLAST	42
Repeatⁱ	140 – 179	WD 4Add BLAST	40
Repeatⁱ	242 – 280	WD 5Add BLAST	39
Repeatⁱ	324 – 367	WD 6Add BLAST	44

Sequence similaritiesⁱ

Belongs to the WD repeat ARPC1 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG1523 Eukaryota ENOG410XNWX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008339
HOGENOMⁱ	HOG000181752
HOVERGENⁱ	HBG050560
InParanoidⁱ	Q9WV32
KEGG Orthology (KO) More...KOⁱ	K05757
OMAⁱ	VLFTYDS
TreeFamⁱ	TF315041

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR030141 ARC1B IPR017383 ARPC1 IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR10709 PTHR10709, 1 hit PTHR10709:SF10 PTHR10709:SF10, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 2 hits
PIRSFⁱ	PIRSF038093 ARP2/3_su1, 1 hit
SMARTⁱ	View protein in SMART SM00320 WD40, 5 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50082 WD_REPEATS_2, 1 hit PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q9WV32-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWNKVHELKE 
        60         70         80         90        100
HNGQVTGIDW APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR 
       110        120        130        140        150
CVRWAPNENK FAVGSGSRVI SICYFEQEND WWVCKHIKKP IRSTVLSLDW 
       160        170        180        190        200
HPNNVLLAAG SCDFKCRIFS AYIKEVEERP APTPWGSKMP FGELMFESSS 
       210        220        230        240        250
SCGWVHGVCF SASGSRVAWV SHDSTVCLVD ADKKMAVATL ASETLPLLAV 
       260        270        280        290        300
TFITENSLVA AGHDCFPVLF TYDNAAVTLS FGGRLDVPKQ SSQRGMTARE 
       310        320        330        340        350
RFQNLDKKAS SEGGAATGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM 
       360        370 
DGGMSIWDVK SLESALKDLK IK

Length:372

Mass (Da):41,064

Last modified:July 27, 2011 - v4

Checksum:ⁱ0315BFB6E8697D89

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q91Z25	Q91Z25_MOUSE	Actin-related protein 2/3 complex s... Actin-related protein 2/3 complex subunit	Arpc1b	376	Annotation score:
D3Z6S0	D3Z6S0_MOUSE	Actin-related protein 2/3 complex s... Actin-related protein 2/3 complex subunit 1B	Arpc1b	56	Annotation score:
F6VVE6	F6VVE6_MOUSE	Actin-related protein 2/3 complex s... Actin-related protein 2/3 complex subunit 1B	Arpc1b	232	Annotation score:
F6THG2	F6THG2_MOUSE	Actin-related protein 2/3 complex s... Actin-related protein 2/3 complex subunit 1B	Arpc1b	105	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	112	A → R in AAD43352 (Ref. 1) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF162768 mRNA Translation: AAD43352.1 AK002274 mRNA Translation: BAB21980.1 AK005378 mRNA Translation: BAB23985.1 AK147731 mRNA Translation: BAE28101.1 AK148145 mRNA Translation: BAE28373.1 AK159371 mRNA Translation: BAE35028.1 AK167978 mRNA Translation: BAE39970.1 AK168774 mRNA Translation: BAE40610.1 AK172124 mRNA Translation: BAE42835.1 CH466529 Genomic DNA Translation: EDL19001.1 CH466529 Genomic DNA Translation: EDL19002.1 BC003441 mRNA Translation: AAH03441.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19856.1
NCBI Reference Sequences More...RefSeqⁱ	NP_075631.2, NM_023142.2
UniGeneⁱ	Mm.30010

Genome annotation databases

Ensemblⁱ	ENSMUST00000085679; ENSMUSP00000082822; ENSMUSG00000029622
GeneIDⁱ	11867
KEGGⁱ	mmu:11867
UCSC genome browser More...UCSCⁱ	uc009amb.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9WV32	Actin-related protein 2/3 complex subunit 1B		HUMAN		372	UniRef90_O15143
Actin-related protein 2/3 complex subunit 1B		RAT		372
Actin-related protein 2/3 complex subunit 1B	)	BOVIN		372
Actin-related protein 2/3 complex subunit		PANPA		372
Actin related protein 2/3 complex subunit 1B		PONAB		435
+141

Protein	Similar proteins		Species	Score	Length	Source
Q9WV32	Actin-related protein 2/3 complex subunit 1B		HUMAN		372	UniRef50_O15143
Actin-related protein 2/3 complex subunit 1B	)	BOVIN		372
Actin-related protein 2/3 complex subunit 1B		RAT		372
Actin-related protein 2/3 complex subunit 1A		MOUSE		370
Actin-related protein 2/3 complex subunit		PANPA		372
+494

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF162768 mRNA Translation: AAD43352.1 AK002274 mRNA Translation: BAB21980.1 AK005378 mRNA Translation: BAB23985.1 AK147731 mRNA Translation: BAE28101.1 AK148145 mRNA Translation: BAE28373.1 AK159371 mRNA Translation: BAE35028.1 AK167978 mRNA Translation: BAE39970.1 AK168774 mRNA Translation: BAE40610.1 AK172124 mRNA Translation: BAE42835.1 CH466529 Genomic DNA Translation: EDL19001.1 CH466529 Genomic DNA Translation: EDL19002.1 BC003441 mRNA Translation: AAH03441.1
CCDSⁱ	CCDS19856.1
RefSeqⁱ	NP_075631.2, NM_023142.2
UniGeneⁱ	Mm.30010

3D structure databases

ProteinModelPortalⁱ	Q9WV32
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198208, 3 interactors
IntActⁱ	Q9WV32, 3 interactors
MINTⁱ	Q9WV32
STRINGⁱ	10090.ENSMUSP00000082822

PTM databases

iPTMnetⁱ	Q9WV32
PhosphoSitePlusⁱ	Q9WV32
SwissPalmⁱ	Q9WV32

Proteomic databases

EPDⁱ	Q9WV32
MaxQBⁱ	Q9WV32
PaxDbⁱ	Q9WV32
PRIDEⁱ	Q9WV32

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000085679; ENSMUSP00000082822; ENSMUSG00000029622
GeneIDⁱ	11867
KEGGⁱ	mmu:11867
UCSCⁱ	uc009amb.2 mouse

Organism-specific databases

CTDⁱ	10095
MGIⁱ	MGI:1343142 Arpc1b

Phylogenomic databases

eggNOGⁱ	KOG1523 Eukaryota ENOG410XNWX LUCA
GeneTreeⁱ	ENSGT00390000008339
HOGENOMⁱ	HOG000181752
HOVERGENⁱ	HBG050560
InParanoidⁱ	Q9WV32
KOⁱ	K05757
OMAⁱ	VLFTYDS
TreeFamⁱ	TF315041

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation R-MMU-3928662 EPHB-mediated forward signaling R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Reactomeⁱ

R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs

Miscellaneous databases

ChiTaRSⁱ	Arpc1b mouse
Protein Ontology More...PROⁱ	PR:Q9WV32
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029622 Expressed in 150 organ(s), highest expression level in humerus cartilage element
CleanExⁱ	MM_ARPC1B
ExpressionAtlasⁱ	Q9WV32 baseline and differential
Genevisibleⁱ	Q9WV32 MM

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR030141 ARC1B IPR017383 ARPC1 IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR10709 PTHR10709, 1 hit PTHR10709:SF10 PTHR10709:SF10, 1 hit
Pfamⁱ	View protein in Pfam PF00400 WD40, 2 hits
PIRSFⁱ	PIRSF038093 ARP2/3_su1, 1 hit
SMARTⁱ	View protein in SMART SM00320 WD40, 5 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50082 WD_REPEATS_2, 1 hit PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARC1B_MOUSE
Accessionⁱ	Q9WV32Primary (citable) accession number: Q9WV32 Secondary accession number(s): Q9CRC4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9WV32 (ARC1B_MOUSE)

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Actin-related protein 2/3 complex subunit 1B

Arpc1b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ