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Protein

Troponin I, slow skeletal muscle

Gene

Tnni1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi106 – 117By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • muscle contraction Source: GO_Central
  • regulation of muscle contraction Source: MGI
  • transition between fast and slow fiber Source: MGI
  • ventricular cardiac muscle tissue morphogenesis Source: MGI

Keywordsi

Molecular functionActin-binding, Muscle protein
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, slow skeletal muscle
Alternative name(s):
Troponin I, slow-twitch isoform
Gene namesi
Name:Tnni1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:105073 Tnni1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861402 – 187Troponin I, slow skeletal muscleAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei58PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9WUZ5
PaxDbiQ9WUZ5
PRIDEiQ9WUZ5

PTM databases

iPTMnetiQ9WUZ5
PhosphoSitePlusiQ9WUZ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000026418 Expressed in 148 organ(s), highest expression level in soleus muscle
CleanExiMM_TNNI1
ExpressionAtlasiQ9WUZ5 baseline and differential
GenevisibleiQ9WUZ5 MM

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121343

Structurei

3D structure databases

ProteinModelPortaliQ9WUZ5
SMRiQ9WUZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 48Involved in binding TNCAdd BLAST47
Regioni97 – 118Involved in binding TNC and actinAdd BLAST22

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiKOG3977 Eukaryota
ENOG410Y9IX LUCA
GeneTreeiENSGT00390000002746
HOGENOMiHOG000293300
HOVERGENiHBG052737
InParanoidiQ9WUZ5
KOiK10371
OMAiCRDLHAK
OrthoDBiEOG091G0NOD
PhylomeDBiQ9WUZ5
TreeFamiTF313374

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR001978 Troponin
IPR038077 Troponin_sf
PfamiView protein in Pfam
PF00992 Troponin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9WUZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEVERKSKI TASRKLMLKS LMLAKAKECW EQEHEEREAE KVRYLSERIP
60 70 80 90 100
TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK
110 120 130 140 150
VLDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT
160 170 180
EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTSQ
Length:187
Mass (Da):21,698
Last modified:January 23, 2007 - v3
Checksum:i69B4BA39D0F471D4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUN3D3YUN3_MOUSE
Troponin I, slow skeletal muscle
Tnni1
171Annotation score:
F6QC77F6QC77_MOUSE
Troponin I, slow skeletal muscle
Tnni1
181Annotation score:
D3YTL4D3YTL4_MOUSE
Troponin I, slow skeletal muscle
Tnni1
60Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242874 mRNA Translation: CAB48403.1
AK012258 mRNA Translation: BAB28123.1
BC023170 mRNA Translation: AAH23170.1
CCDSiCCDS48374.1
RefSeqiNP_001106173.1, NM_001112702.1
NP_067442.1, NM_021467.5
XP_006529445.1, XM_006529382.3
XP_011246276.1, XM_011247974.2
UniGeneiMm.44379

Genome annotation databases

EnsembliENSMUST00000148201; ENSMUSP00000123509; ENSMUSG00000026418
ENSMUST00000152075; ENSMUSP00000121343; ENSMUSG00000026418
ENSMUST00000152208; ENSMUSP00000121966; ENSMUSG00000026418
ENSMUST00000154463; ENSMUSP00000122925; ENSMUSG00000026418
GeneIDi21952
KEGGimmu:21952
UCSCiuc033flo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242874 mRNA Translation: CAB48403.1
AK012258 mRNA Translation: BAB28123.1
BC023170 mRNA Translation: AAH23170.1
CCDSiCCDS48374.1
RefSeqiNP_001106173.1, NM_001112702.1
NP_067442.1, NM_021467.5
XP_006529445.1, XM_006529382.3
XP_011246276.1, XM_011247974.2
UniGeneiMm.44379

3D structure databases

ProteinModelPortaliQ9WUZ5
SMRiQ9WUZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121343

PTM databases

iPTMnetiQ9WUZ5
PhosphoSitePlusiQ9WUZ5

Proteomic databases

MaxQBiQ9WUZ5
PaxDbiQ9WUZ5
PRIDEiQ9WUZ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000148201; ENSMUSP00000123509; ENSMUSG00000026418
ENSMUST00000152075; ENSMUSP00000121343; ENSMUSG00000026418
ENSMUST00000152208; ENSMUSP00000121966; ENSMUSG00000026418
ENSMUST00000154463; ENSMUSP00000122925; ENSMUSG00000026418
GeneIDi21952
KEGGimmu:21952
UCSCiuc033flo.1 mouse

Organism-specific databases

CTDi7135
MGIiMGI:105073 Tnni1

Phylogenomic databases

eggNOGiKOG3977 Eukaryota
ENOG410Y9IX LUCA
GeneTreeiENSGT00390000002746
HOGENOMiHOG000293300
HOVERGENiHBG052737
InParanoidiQ9WUZ5
KOiK10371
OMAiCRDLHAK
OrthoDBiEOG091G0NOD
PhylomeDBiQ9WUZ5
TreeFamiTF313374

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Miscellaneous databases

ChiTaRSiTnni1 mouse
PROiPR:Q9WUZ5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026418 Expressed in 148 organ(s), highest expression level in soleus muscle
CleanExiMM_TNNI1
ExpressionAtlasiQ9WUZ5 baseline and differential
GenevisibleiQ9WUZ5 MM

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR001978 Troponin
IPR038077 Troponin_sf
PfamiView protein in Pfam
PF00992 Troponin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNNI1_MOUSE
AccessioniPrimary (citable) accession number: Q9WUZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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