Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 100 (13 Feb 2019)
Sequence version 2 (02 Oct 2007)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Protein MRVI1

Gene

Mrvi1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.4 Publications

Miscellaneous

Mrvi1 gene is a common integration site of murine leukemia virus, leading to induce myeloid leukemia in BXH2 mice. Murine leukemia virus integration occurs at the 5' end of the gene between 2 differentially used promoters and thus probably alters the expression of an important gene for myeloid cell growth.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cGMP-mediated signaling Source: MGI
  • negative regulation of smooth muscle contraction Source: MGI
  • relaxation of vascular smooth muscle Source: MGI

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-418457 cGMP effects

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MRVI1
Alternative name(s):
Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate
JAW1-related protein MRVI1
Murine retrovirus integration site 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mrvi1
Synonyms:Irag
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1338023 Mrvi1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei839 – 859HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice lacking coiled-coil region N-terminal part exhibit disruption of Mrvi1-Itpr1 interaction. They have dilated gastrointestinal tract and disturbed gastrointestinal motility. Smooth muscle are no more relaxed by cGMP after phenilephrine-induced contraction and half of the homozygous mice dies before the age of 6 months. Nitric oxide (NO) and cGMP-mediated inhibition of collagen-induced platelet aggregation is strongly suppressed in platelets of these transgenic mice. growth.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003052931 – 899Protein MRVI1Add BLAST899

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei106PhosphoserineBy similarity1
Modified residuei382PhosphoserineCombined sources1
Modified residuei670PhosphoserineBy similarity1
Modified residuei683PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PRKG1/cGKI.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9WUX5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9WUX5

PRoteomics IDEntifications database

More...
PRIDEi
Q9WUX5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9WUX5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WUX5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in smooth muscle such as aorta, colon and uterus. Detected in the brain, in the thalamus, in the hippocampus and myenteric plexus. Highly expressed in megakaryocytes. Down-regulated during macrophage differentiation.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000005611 Expressed in 227 organ(s), highest expression level in uterus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9WUX5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9WUX5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with PRKG1/cGKI-beta and ITPR1/IP3R type I.By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000114578

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni140 – 172Interaction with PRKG1By similarityAdd BLAST33
Regioni521 – 567Interaction with ITPR11 PublicationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili534 – 632Sequence analysisAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi755 – 823Glu-richAdd BLAST69

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG5G Eukaryota
ENOG410XVI5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063722

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113653

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG078204

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9WUX5

Database of Orthologous Groups

More...
OrthoDBi
560334at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9WUX5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008677 MRVI1

The PANTHER Classification System

More...
PANTHERi
PTHR15352 PTHR15352, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05781 MRVI1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9WUX5-1) [UniParc]FASTAAdd to basket
Also known as: Mrvi1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRSLTCPFG ISPACGAQAS WSIFGVGTAE VPGTHSHSNQ AAAMPHIPED
60 70 80 90 100
EEPPGEPQAA QTQDSPSAGP FPSPPTIVLT GDASSPEGET DKNLVNRAPS
110 120 130 140 150
PHRRLSHRHL KVSTASLTSV DPSGHVIDLV NDQLPDISIS EEDKKKNLAL
160 170 180 190 200
LEEAKLVSER FLTRRGRKSR SSLGDSPSAV SPNLSSGASP ASSRSCSLTI
210 220 230 240 250
STSPGLDICS GPQSPLPGAP PQQKGHEDGV SSPCPGEPNV SKGLADLKQN
260 270 280 290 300
DQRKVSQGRL APRSPTVEKT KELTVEQKEN FDPLQHVEAT PMAQASGASI
310 320 330 340 350
SGKMALNSPQ PGPAEMELGR QLLKTAREGN PLPRTTAQGS GGTVSPHSLG
360 370 380 390 400
QGSAGEPMGP KAGSKAELRS PVSRPPLIRG VSWDSSPEEP GPLLQKVLAK
410 420 430 440 450
LPLAEEEKRF PGKAKPAKPP GLKDFQIQVQ PVRMQKLTKL REEHILMRNQ
460 470 480 490 500
NLVGFKLPEL SEAAEQDKGV SPELAPAAEE EESKSGLDVM PNISDILLRK
510 520 530 540 550
LRVHKSLTGS APPLTEKEVE NVFVQLSLAF RNDSYTLESR INQAERERNL
560 570 580 590 600
TEENTEKELE NFKASITSSA NIWYHCEHRE TYQKLLEDIA VLHRLAARLS
610 620 630 640 650
SRAEVVGAVR QEKRMSKATE VMMQYVENLK RTYEKDHAEL MEFKKLANQN
660 670 680 690 700
SSRSCGPSED GVPRTARSMS LTMGKNMPRR RVSVAVVPKF NALNLPGQAP
710 720 730 740 750
SSSPMPSLPA LSESSNGKSS ISVSPALPAL LENGKTNAEA NCEVGAPVPL
760 770 780 790 800
PSCLEETSQE TKAKAEEEAY SKGYQEGVKK TEELQDLKEE EEEEQKTESP
810 820 830 840 850
EEPEEVEETQ EDEKDQGSSK LEELVHFLQV MYPKLCQHWQ VIWMMAAVML
860 870 880 890
VLSVVLGLYS SYNSCTEEAD GPPGRSTCSA AQRDSWWSSG LQQELPAEQ
Length:899
Mass (Da):97,434
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CDD441A14225D60
GO
Isoform 2 (identifier: Q9WUX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Show »
Length:856
Mass (Da):93,192
Checksum:iD3D9AFC6E8B4C1FA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UR44Q3UR44_MOUSE
Protein MRVI1
Mrvi1
715Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E8V5G5E8V5_MOUSE
MRV integration site 1, isoform CRA...
Mrvi1 mCG_7238
921Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YUG8D3YUG8_MOUSE
Protein MRVI1
Mrvi1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD22569 differs from that shown. Reason: Frameshift at position 1.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11I → V in AAD22569 (PubMed:10321731).Curated1
Sequence conflicti203S → P in BAE33986 (PubMed:16141072).Curated1
Sequence conflicti206L → G in AAD22568 (PubMed:10321731).Curated1
Sequence conflicti206L → G in AAD22569 (PubMed:10321731).Curated1
Sequence conflicti209C → W in AAD22568 (PubMed:10321731).Curated1
Sequence conflicti209C → W in AAD22569 (PubMed:10321731).Curated1
Sequence conflicti220P → L in BAE33986 (PubMed:16141072).Curated1
Sequence conflicti224K → R in AAD22568 (PubMed:10321731).Curated1
Sequence conflicti224K → R in AAD22569 (PubMed:10321731).Curated1
Sequence conflicti235P → L in BAE33986 (PubMed:16141072).Curated1
Sequence conflicti349L → P in BAE33986 (PubMed:16141072).Curated1
Sequence conflicti647A → S in AAD22568 (PubMed:10321731).Curated1
Sequence conflicti647A → S in AAD22569 (PubMed:10321731).Curated1
Sequence conflicti731L → G in AAD22568 (PubMed:10321731).Curated1
Sequence conflicti731L → G in AAD22569 (PubMed:10321731).Curated1
Sequence conflicti738A → E in AAD22568 (PubMed:10321731).Curated1
Sequence conflicti738A → E in AAD22569 (PubMed:10321731).Curated1
Sequence conflicti773G → E in BAE33986 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0283431 – 43Missing in isoform 2. 2 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U63407 mRNA Translation: AAD22568.1
U63408 mRNA Translation: AAD22569.1 Frameshift.
AK157169 mRNA Translation: BAE33986.1
AC159206 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS21749.1 [Q9WUX5-2]

NCBI Reference Sequences

More...
RefSeqi
XP_006507478.1, XM_006507415.2 [Q9WUX5-2]
XP_006507479.1, XM_006507416.3 [Q9WUX5-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.250023
Mm.491237

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000005751; ENSMUSP00000005751; ENSMUSG00000005611 [Q9WUX5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17540

UCSC genome browser

More...
UCSCi
uc009jfs.2 mouse [Q9WUX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63407 mRNA Translation: AAD22568.1
U63408 mRNA Translation: AAD22569.1 Frameshift.
AK157169 mRNA Translation: BAE33986.1
AC159206 Genomic DNA No translation available.
CCDSiCCDS21749.1 [Q9WUX5-2]
RefSeqiXP_006507478.1, XM_006507415.2 [Q9WUX5-2]
XP_006507479.1, XM_006507416.3 [Q9WUX5-2]
UniGeneiMm.250023
Mm.491237

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114578

PTM databases

iPTMnetiQ9WUX5
PhosphoSitePlusiQ9WUX5

Proteomic databases

jPOSTiQ9WUX5
PaxDbiQ9WUX5
PRIDEiQ9WUX5

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
17540
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005751; ENSMUSP00000005751; ENSMUSG00000005611 [Q9WUX5-2]
GeneIDi17540
UCSCiuc009jfs.2 mouse [Q9WUX5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10335
MGIiMGI:1338023 Mrvi1

Phylogenomic databases

eggNOGiENOG410IG5G Eukaryota
ENOG410XVI5 LUCA
GeneTreeiENSGT00530000063722
HOGENOMiHOG000113653
HOVERGENiHBG078204
InParanoidiQ9WUX5
OrthoDBi560334at2759
PhylomeDBiQ9WUX5

Enzyme and pathway databases

ReactomeiR-MMU-418457 cGMP effects

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mrvi1 mouse

Protein Ontology

More...
PROi
PR:Q9WUX5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005611 Expressed in 227 organ(s), highest expression level in uterus
ExpressionAtlasiQ9WUX5 baseline and differential
GenevisibleiQ9WUX5 MM

Family and domain databases

InterProiView protein in InterPro
IPR008677 MRVI1
PANTHERiPTHR15352 PTHR15352, 1 hit
PfamiView protein in Pfam
PF05781 MRVI1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRVI1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WUX5
Secondary accession number(s): Q3U069, Q9R2C5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: February 13, 2019
This is version 100 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again