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Protein

Origin recognition complex subunit 5

Gene

Orc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 44ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA replication origin binding Source: GO_Central

GO - Biological processi

  • DNA replication Source: MGI
  • DNA replication initiation Source: GO_Central

Keywordsi

Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-176187 Activation of ATR in response to replication stress
R-MMU-68616 Assembly of the ORC complex at the origin of replication
R-MMU-68689 CDC6 association with the ORC:origin complex
R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex
R-MMU-68867 Assembly of the pre-replicative complex
R-MMU-68949 Orc1 removal from chromatin
R-MMU-68962 Activation of the pre-replicative complex

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 5
Gene namesi
Name:Orc5
Synonyms:Orc5l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1347044 Orc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001270931 – 435Origin recognition complex subunit 5Add BLAST435

Proteomic databases

EPDiQ9WUV0
MaxQBiQ9WUV0
PaxDbiQ9WUV0
PeptideAtlasiQ9WUV0
PRIDEiQ9WUV0

PTM databases

iPTMnetiQ9WUV0
PhosphoSitePlusiQ9WUV0

Expressioni

Gene expression databases

BgeeiENSMUSG00000029012 Expressed in 299 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ9WUV0 baseline and differential
GenevisibleiQ9WUV0 MM

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity).By similarity

Protein-protein interaction databases

BioGridi204981, 1 interactor
ComplexPortaliCPX-1915 Nuclear origin of replication recognition complex
CORUMiQ9WUV0
IntActiQ9WUV0, 2 interactors
MINTiQ9WUV0
STRINGi10090.ENSMUSP00000030872

Structurei

3D structure databases

ProteinModelPortaliQ9WUV0
SMRiQ9WUV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC5 family.Curated

Phylogenomic databases

eggNOGiKOG2543 Eukaryota
ENOG410XSY0 LUCA
GeneTreeiENSGT00390000009380
HOGENOMiHOG000252906
HOVERGENiHBG007875
InParanoidiQ9WUV0
KOiK02607
OMAiGEQNIMD
OrthoDBiEOG091G0D0I
PhylomeDBiQ9WUV0
TreeFamiTF101095

Family and domain databases

InterProiView protein in InterPro
IPR020796 ORC5
IPR027417 P-loop_NTPase
PANTHERiPTHR12705 PTHR12705, 1 hit
PfamiView protein in Pfam
PF14630 ORC5_C, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WUV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHLESMVLC REAQVSTLQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL
60 70 80 90 100
LKTLELPHAF VNCVECFTSR LLLEQILNKL SHLNSSDAGC STEMTCETFN
110 120 130 140 150
DFVQLFKQVT SAEHLKDQTV YIVLDKAEYL RDMEANLLPG LLRLQELTDR
160 170 180 190 200
NVTVIFLSEI IWEKFRPNTG CFEPFVLYFP DYSIGNLQKI LSHDHPPEYS
210 220 230 240 250
ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV VKGEAGERDT
260 270 280 290 300
RKLWRNIEPH LKKAMQTVYL REISSSQWEK LQKDNTDPGQ LKGLSAYTHM
310 320 330 340 350
ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH
360 370 380 390 400
LLGPKPFPLD RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTIVGHED
410 420 430
QLNGPKYKCT VSLDFIRAIA RMVNFDIIKY LYDFL
Length:435
Mass (Da):50,217
Last modified:November 1, 1999 - v1
Checksum:i1F334E35379F5C69
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0X3D3Z0X3_MOUSE
Origin recognition complex subunit ...
Orc5
312Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007360 mRNA Translation: CAB43767.1
AK084683 mRNA Translation: BAC39250.1
AK144983 mRNA Translation: BAE26167.1
AK165912 mRNA Translation: BAE38456.1
AK166537 mRNA Translation: BAE38839.1
BC006927 mRNA Translation: AAH06927.1
CCDSiCCDS19110.1
RefSeqiNP_036089.1, NM_011959.2
UniGeneiMm.412217
Mm.469664

Genome annotation databases

EnsembliENSMUST00000030872; ENSMUSP00000030872; ENSMUSG00000029012
GeneIDi26429
KEGGimmu:26429
UCSCiuc008wpq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007360 mRNA Translation: CAB43767.1
AK084683 mRNA Translation: BAC39250.1
AK144983 mRNA Translation: BAE26167.1
AK165912 mRNA Translation: BAE38456.1
AK166537 mRNA Translation: BAE38839.1
BC006927 mRNA Translation: AAH06927.1
CCDSiCCDS19110.1
RefSeqiNP_036089.1, NM_011959.2
UniGeneiMm.412217
Mm.469664

3D structure databases

ProteinModelPortaliQ9WUV0
SMRiQ9WUV0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204981, 1 interactor
ComplexPortaliCPX-1915 Nuclear origin of replication recognition complex
CORUMiQ9WUV0
IntActiQ9WUV0, 2 interactors
MINTiQ9WUV0
STRINGi10090.ENSMUSP00000030872

PTM databases

iPTMnetiQ9WUV0
PhosphoSitePlusiQ9WUV0

Proteomic databases

EPDiQ9WUV0
MaxQBiQ9WUV0
PaxDbiQ9WUV0
PeptideAtlasiQ9WUV0
PRIDEiQ9WUV0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030872; ENSMUSP00000030872; ENSMUSG00000029012
GeneIDi26429
KEGGimmu:26429
UCSCiuc008wpq.1 mouse

Organism-specific databases

CTDi5001
MGIiMGI:1347044 Orc5

Phylogenomic databases

eggNOGiKOG2543 Eukaryota
ENOG410XSY0 LUCA
GeneTreeiENSGT00390000009380
HOGENOMiHOG000252906
HOVERGENiHBG007875
InParanoidiQ9WUV0
KOiK02607
OMAiGEQNIMD
OrthoDBiEOG091G0D0I
PhylomeDBiQ9WUV0
TreeFamiTF101095

Enzyme and pathway databases

ReactomeiR-MMU-176187 Activation of ATR in response to replication stress
R-MMU-68616 Assembly of the ORC complex at the origin of replication
R-MMU-68689 CDC6 association with the ORC:origin complex
R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex
R-MMU-68867 Assembly of the pre-replicative complex
R-MMU-68949 Orc1 removal from chromatin
R-MMU-68962 Activation of the pre-replicative complex

Miscellaneous databases

PROiPR:Q9WUV0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029012 Expressed in 299 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ9WUV0 baseline and differential
GenevisibleiQ9WUV0 MM

Family and domain databases

InterProiView protein in InterPro
IPR020796 ORC5
IPR027417 P-loop_NTPase
PANTHERiPTHR12705 PTHR12705, 1 hit
PfamiView protein in Pfam
PF14630 ORC5_C, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiORC5_MOUSE
AccessioniPrimary (citable) accession number: Q9WUV0
Secondary accession number(s): Q3TMI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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