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Protein

Cathepsin Z

Gene

Ctsz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.By similarity

Catalytic activityi

Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94PROSITE-ProRule annotation1
Active sitei243PROSITE-ProRule annotation1
Active sitei264PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-MMU-2022377 Metabolism of Angiotensinogen to Angiotensins
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiC01.013

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin Z (EC:3.4.18.1)
Gene namesi
Name:Ctsz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1891190 Ctsz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000002628723 – 63Activation peptideSequence analysisAdd BLAST41
ChainiPRO_000002628864 – 306Cathepsin ZAdd BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi91 ↔ 134By similarity
Disulfide bondi128 ↔ 166By similarity
Disulfide bondi156 ↔ 172By similarity
Disulfide bondi175 ↔ 181By similarity
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 299By similarity
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiQ9WUU7
MaxQBiQ9WUU7
PaxDbiQ9WUU7
PRIDEiQ9WUU7

PTM databases

PhosphoSitePlusiQ9WUU7
SwissPalmiQ9WUU7

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000016256 Expressed in 288 organ(s), highest expression level in ileum
CleanExiMM_CTSZ
ExpressionAtlasiQ9WUU7 baseline and differential
GenevisibleiQ9WUU7 MM

Interactioni

Protein-protein interaction databases

IntActiQ9WUU7, 3 interactors
MINTiQ9WUU7
STRINGi10090.ENSMUSP00000016400

Structurei

3D structure databases

ProteinModelPortaliQ9WUU7
SMRiQ9WUU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140859
HOVERGENiHBG004456
InParanoidiQ9WUU7
KOiK08568
OMAiQCGTCTE
OrthoDBiEOG091G0BNT
PhylomeDBiQ9WUU7
TreeFamiTF313225

Family and domain databases

CDDicd02698 Peptidase_C1A_CathepsinX, 1 hit
InterProiView protein in InterPro
IPR033157 Cathepsin_X
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
PANTHERiPTHR12411 PTHR12411, 1 hit
PTHR12411:SF14 PTHR12411:SF14, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSGSVQQL PLVLLMLLLA SAARARLYFR SGQTCYHPIR GDQLALLGRR
60 70 80 90 100
TYPRPHEYLS PADLPKNWDW RNVNGVNYAS VTRNQHIPQY CGSCWAHGST
110 120 130 140 150
SAMADRINIK RKGAWPSILL SVQNVIDCGN AGSCEGGNDL PVWEYAHKHG
160 170 180 190 200
IPDETCNNYQ AKDQDCDKFN QCGTCTEFKE CHTIQNYTLW RVGDYGSLSG
210 220 230 240 250
REKMMAEIYA NGPISCGIMA TEMMSNYTGG IYAEHQDQAV INHIISVAGW
260 270 280 290 300
GVSNDGIEYW IVRNSWGEPW GEKGWMRIVT STYKGGTGDS YNLAIESACT

FGDPIV
Length:306
Mass (Da):33,996
Last modified:November 1, 1999 - v1
Checksum:i1B94045C3D0A7CFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242663 mRNA Translation: CAB44494.1
AF136277 mRNA Translation: AAF13143.1
AF136278 Genomic DNA Translation: AAF13144.1
BC008619 mRNA Translation: AAH08619.1
CCDSiCCDS17152.1
RefSeqiNP_071720.1, NM_022325.5
UniGeneiMm.156919

Genome annotation databases

EnsembliENSMUST00000016400; ENSMUSP00000016400; ENSMUSG00000016256
GeneIDi64138
KEGGimmu:64138
UCSCiuc008ofd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCATZ_MOUSE
AccessioniPrimary (citable) accession number: Q9WUU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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