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Protein

Hepatocyte nuclear factor 4-gamma

Gene

Hnf4g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor. Has a lower transcription activation potential than HNF4-alpha (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi9 – 84Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri12 – 32NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri48 – 72NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 4-gamma
Short name:
HNF-4-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group A member 2
Gene namesi
Name:Hnf4g
Synonyms:Nr2a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1353604 Hnf4g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535631 – 408Hepatocyte nuclear factor 4-gammaAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94PhosphoserineBy similarity1
Modified residuei370PhosphothreonineBy similarity1
Modified residuei373PhosphothreonineBy similarity1
Modified residuei377PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9WUU6
PaxDbiQ9WUU6
PRIDEiQ9WUU6

PTM databases

iPTMnetiQ9WUU6
PhosphoSitePlusiQ9WUU6

Expressioni

Gene expression databases

CleanExiMM_HNF4G

Interactioni

Protein-protein interaction databases

BioGridi206019, 6 interactors
STRINGi10090.ENSMUSP00000017832

Structurei

3D structure databases

ProteinModelPortaliQ9WUU6
SMRiQ9WUU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 328NR LBDPROSITE-ProRule annotationAdd BLAST230

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 32NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri48 – 72NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4215 Eukaryota
ENOG410XQT8 LUCA
HOGENOMiHOG000260822
HOVERGENiHBG005606
InParanoidiQ9WUU6
KOiK08037

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003068 COUP_TF
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01282 COUPTNFACTOR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9WUU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTTDSGVNC LCAICGDRAT GKHYGASSCD GCKGFFRRSI RKSHVYSCRF
60 70 80 90 100
SRQCVVDKDK RNQCRYCRLR KCFRAGMKKE AVQNERDRIS TRRSTYEGSN
110 120 130 140 150
IPSINTLAQA EVRSCQISVP SPSSSTDINI KKIASISDVC ESMKQQLLVL
160 170 180 190 200
VEWAKYIPAF CELPLDDQVA LLRAHAGEHL LLGATKRSMM YKDILLLGNH
210 220 230 240 250
YVIHRNSCEV EVSRVANRVL DELVRPFQEI QIDDNEYACL KAIVFFDPDA
260 270 280 290 300
KGLSDPVKIK NMRFQVQISL EDYINDRQYD SRGRFGELLL LLPTLQSITW
310 320 330 340 350
QMIEQIQFVK LFGMVKIDNL LQEMLLGGAA NDGSHLHHPM HPHLSQDPLT
360 370 380 390 400
GQTILLGPMS TLVHTDQIAT PETPLPSPPQ GSGQEPYKIT ANQASVISHQ

SLSKQKQL
Length:408
Mass (Da):45,897
Last modified:December 1, 2000 - v2
Checksum:i5E4AF2E53BCDC7F1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QPS1E9QPS1_MOUSE
Hepatocyte nuclear factor 4-gamma
Hnf4g
462Annotation score:
Q059V1Q059V1_MOUSE
Hepatocyte nuclear factor 4, gamma
Hnf4g mCG_7333
418Annotation score:

Sequence cautioni

The sequence CAB43724 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242626 mRNA Translation: CAB43724.1 Different initiation.
RefSeqiNP_038948.1, NM_013920.2
UniGeneiMm.330897

Genome annotation databases

GeneIDi30942
KEGGimmu:30942

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242626 mRNA Translation: CAB43724.1 Different initiation.
RefSeqiNP_038948.1, NM_013920.2
UniGeneiMm.330897

3D structure databases

ProteinModelPortaliQ9WUU6
SMRiQ9WUU6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206019, 6 interactors
STRINGi10090.ENSMUSP00000017832

PTM databases

iPTMnetiQ9WUU6
PhosphoSitePlusiQ9WUU6

Proteomic databases

MaxQBiQ9WUU6
PaxDbiQ9WUU6
PRIDEiQ9WUU6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30942
KEGGimmu:30942

Organism-specific databases

CTDi3174
MGIiMGI:1353604 Hnf4g

Phylogenomic databases

eggNOGiKOG4215 Eukaryota
ENOG410XQT8 LUCA
HOGENOMiHOG000260822
HOVERGENiHBG005606
InParanoidiQ9WUU6
KOiK08037

Miscellaneous databases

PROiPR:Q9WUU6
SOURCEiSearch...

Gene expression databases

CleanExiMM_HNF4G

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003068 COUP_TF
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01282 COUPTNFACTOR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHNF4G_MOUSE
AccessioniPrimary (citable) accession number: Q9WUU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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