UniProtKB - Q9WUT7 (CCR9_MOUSE)
Protein
C-C chemokine receptor type 9
Gene
Ccr9
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- C-C chemokine receptor activity Source: MGI
- chemokine binding Source: GO_Central
GO - Biological processi
- calcium-mediated signaling Source: GO_Central
- CD8-positive, gamma-delta intraepithelial T cell differentiation Source: MGI
- cell chemotaxis Source: GO_Central
- chemotaxis Source: MGI
- immune response Source: GO_Central
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-C chemokine receptor type 9Short name: C-C CKR-9 Short name: CC-CKR-9 Short name: CCR-9 Alternative name(s): Chemokine C-C receptor 10 CD_antigen: CDw199 |
Gene namesi | Name:Ccr9 Synonyms:Cmkbr10 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1341902, Ccr9 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 48 | ExtracellularBy similarityAdd BLAST | 48 | |
Transmembranei | 49 – 74 | Helical; Name=1By similarityAdd BLAST | 26 | |
Topological domaini | 75 – 85 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 86 – 109 | Helical; Name=2By similarityAdd BLAST | 24 | |
Topological domaini | 110 – 120 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 121 – 150 | Helical; Name=3By similarityAdd BLAST | 30 | |
Topological domaini | 151 – 159 | CytoplasmicBy similarity | 9 | |
Transmembranei | 160 – 185 | Helical; Name=4By similarityAdd BLAST | 26 | |
Topological domaini | 186 – 208 | ExtracellularBy similarityAdd BLAST | 23 | |
Transmembranei | 209 – 243 | Helical; Name=5By similarityAdd BLAST | 35 | |
Topological domaini | 244 – 248 | CytoplasmicBy similarity | 5 | |
Transmembranei | 249 – 283 | Helical; Name=6By similarityAdd BLAST | 35 | |
Topological domaini | 284 – 290 | ExtracellularBy similarity | 7 | |
Transmembranei | 291 – 321 | Helical; Name=7By similarityAdd BLAST | 31 | |
Topological domaini | 322 – 369 | CytoplasmicBy similarityAdd BLAST | 48 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069292 | 1 – 369 | C-C chemokine receptor type 9Add BLAST | 369 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 38 ↔ 289 | By similarity | ||
Disulfide bondi | 119 ↔ 198 | PROSITE-ProRule annotationBy similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9WUT7 |
PaxDbi | Q9WUT7 |
PRIDEi | Q9WUT7 |
PTM databases
GlyGeni | Q9WUT7, 1 site |
iPTMneti | Q9WUT7 |
PhosphoSitePlusi | Q9WUT7 |
Expressioni
Tissue specificityi
Highly expressed in the thymus and low in lymph nodes and spleen.
Gene expression databases
Bgeei | ENSMUSG00000029530, Expressed in thymus and 158 other tissues |
ExpressionAtlasi | Q9WUT7, baseline and differential |
Genevisiblei | Q9WUT7, MM |
Interactioni
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- chemokine binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 198769, 1 interactor |
DIPi | DIP-5886N |
STRINGi | 10090.ENSMUSP00000127024 |
Miscellaneous databases
RNActi | Q9WUT7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000182749 |
InParanoidi | Q9WUT7 |
OrthoDBi | 800663at2759 |
PhylomeDBi | Q9WUT7 |
TreeFami | TF330966 |
Family and domain databases
InterProi | View protein in InterPro IPR004069, Chemokine_CCR9 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01531, CHEMOKINER9 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9WUT7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMPTELTSLI PGMFDDFSYD STASTDDYMN LNFSSFFCKK NNVRQFASHF
60 70 80 90 100
LPPLYWLVFI VGTLGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLAT
110 120 130 140 150
LPFWAIAAAG QWMFQTFMCK VVNSMYKMNF YSCVLLIMCI SVDRYIAIVQ
160 170 180 190 200
AMKAQVWRQK RLLYSKMVCI TIWVMAAVLC TPEILYSQVS GESGIATCTM
210 220 230 240 250
VYPKDKNAKL KSAVLILKVT LGFFLPFMVM AFCYTIIIHT LVQAKKSSKH
260 270 280 290 300
KALKVTITVL TVFIMSQFPY NSILVVQAVD AYAMFISNCT ISTNIDICFQ
310 320 330 340 350
VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE
360
GSLKLSSMLL ETTSGALSL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WIS0 | F8WIS0_MOUSE | C-C chemokine receptor type 9 | Ccr9 | 357 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ132336 mRNA Translation: CAB43480.1 AJ131357 mRNA Translation: CAB66136.2 AK019478 mRNA Translation: BAB31747.1 AK050615 mRNA Translation: BAC34344.1 AK153975 mRNA Translation: BAE32291.1 BC132166 mRNA Translation: AAI32167.1 BC132466 mRNA Translation: AAI32467.1 |
CCDSi | CCDS23662.1 |
RefSeqi | NP_001160097.1, NM_001166625.1 NP_034043.1, NM_009913.6 |
Genome annotation databases
Ensembli | ENSMUST00000163559; ENSMUSP00000131782; ENSMUSG00000029530 ENSMUST00000166236; ENSMUSP00000127024; ENSMUSG00000029530 ENSMUST00000168910; ENSMUSP00000126758; ENSMUSG00000029530 ENSMUST00000180093; ENSMUSP00000137144; ENSMUSG00000029530 |
GeneIDi | 12769 |
KEGGi | mmu:12769 |
UCSCi | uc009sgl.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ132336 mRNA Translation: CAB43480.1 AJ131357 mRNA Translation: CAB66136.2 AK019478 mRNA Translation: BAB31747.1 AK050615 mRNA Translation: BAC34344.1 AK153975 mRNA Translation: BAE32291.1 BC132166 mRNA Translation: AAI32167.1 BC132466 mRNA Translation: AAI32467.1 |
CCDSi | CCDS23662.1 |
RefSeqi | NP_001160097.1, NM_001166625.1 NP_034043.1, NM_009913.6 |
3D structure databases
SMRi | Q9WUT7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198769, 1 interactor |
DIPi | DIP-5886N |
STRINGi | 10090.ENSMUSP00000127024 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9WUT7, 1 site |
iPTMneti | Q9WUT7 |
PhosphoSitePlusi | Q9WUT7 |
Proteomic databases
jPOSTi | Q9WUT7 |
PaxDbi | Q9WUT7 |
PRIDEi | Q9WUT7 |
Protocols and materials databases
Antibodypediai | 3479, 617 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 10803 |
MGIi | MGI:1341902, Ccr9 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000182749 |
InParanoidi | Q9WUT7 |
OrthoDBi | 800663at2759 |
PhylomeDBi | Q9WUT7 |
TreeFami | TF330966 |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 12769, 0 hits in 17 CRISPR screens |
ChiTaRSi | Ccr9, mouse |
PROi | PR:Q9WUT7 |
RNActi | Q9WUT7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029530, Expressed in thymus and 158 other tissues |
ExpressionAtlasi | Q9WUT7, baseline and differential |
Genevisiblei | Q9WUT7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004069, Chemokine_CCR9 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01531, CHEMOKINER9 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCR9_MOUSE | |
Accessioni | Q9WUT7Primary (citable) accession number: Q9WUT7 Secondary accession number(s): A2RSM5, Q543I4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries