Ccr9

Functionⁱ

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functionⁱ

C-C chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
C-C chemokine receptor activity
Source: MGI
Inferred from direct assayⁱ
- 10623805
chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-mediated signaling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
CD8-positive, gamma-delta intraepithelial T cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 25348153
cell chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemotaxis
Source: MGI
Inferred from direct assayⁱ
- 10623805
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cytosolic calcium ion concentration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-C chemokine receptor type 9 Short name: C-C CKR-9 Short name: CC-CKR-9 Short name: CCR-9 Alternative name(s): Chemokine C-C receptor 10 CD_antigen: CDw199
Gene namesⁱ	Name:Ccr9 Synonyms:Cmkbr10
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:1341902 Ccr9

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 48	ExtracellularBy similarityAdd BLAST	48
Transmembraneⁱ	49 – 74	Helical; Name=1By similarityAdd BLAST	26
Topological domainⁱ	75 – 85	CytoplasmicBy similarityAdd BLAST	11
Transmembraneⁱ	86 – 109	Helical; Name=2By similarityAdd BLAST	24
Topological domainⁱ	110 – 120	ExtracellularBy similarityAdd BLAST	11
Transmembraneⁱ	121 – 150	Helical; Name=3By similarityAdd BLAST	30
Topological domainⁱ	151 – 159	CytoplasmicBy similarity	9
Transmembraneⁱ	160 – 185	Helical; Name=4By similarityAdd BLAST	26
Topological domainⁱ	186 – 208	ExtracellularBy similarityAdd BLAST	23
Transmembraneⁱ	209 – 243	Helical; Name=5By similarityAdd BLAST	35
Topological domainⁱ	244 – 248	CytoplasmicBy similarity	5
Transmembraneⁱ	249 – 283	Helical; Name=6By similarityAdd BLAST	35
Topological domainⁱ	284 – 290	ExtracellularBy similarity	7
Transmembraneⁱ	291 – 321	Helical; Name=7By similarityAdd BLAST	31
Topological domainⁱ	322 – 369	CytoplasmicBy similarityAdd BLAST	48

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069292	1 – 369	C-C chemokine receptor type 9Add BLAST		369

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	32	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	38 ↔ 289	By similarity
Disulfide bondⁱ	119 ↔ 198	PROSITE-ProRule annotationBy similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9WUT7
PRIDEⁱ	Q9WUT7

PTM databases

iPTMnetⁱ	Q9WUT7
PhosphoSitePlusⁱ	Q9WUT7

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the thymus and low in lymph nodes and spleen.

Gene expression databases

Bgeeⁱ	ENSMUSG00000029530 Expressed in 138 organ(s), highest expression level in thymus
CleanExⁱ	MM_CCR9
ExpressionAtlasⁱ	Q9WUT7 baseline and differential
Genevisibleⁱ	Q9WUT7 MM

Interactionⁱ

GO - Molecular functionⁱ

C-C chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198769, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-5886N
STRINGⁱ	10090.ENSMUSP00000126758

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9WUT7
SMRⁱ	Q9WUT7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150843
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG106917
InParanoidⁱ	Q9WUT7
KEGG Orthology (KO) More...KOⁱ	K04184
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G093O
PhylomeDBⁱ	Q9WUT7
TreeFamⁱ	TF330966

Family and domain databases

InterProⁱ	View protein in InterPro IPR004069 Chemokine_CCR9 IPR000355 Chemokine_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00657 CCCHEMOKINER PR01531 CHEMOKINER9 PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9WUT7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMPTELTSLI PGMFDDFSYD STASTDDYMN LNFSSFFCKK NNVRQFASHF 
        60         70         80         90        100
LPPLYWLVFI VGTLGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLAT 
       110        120        130        140        150
LPFWAIAAAG QWMFQTFMCK VVNSMYKMNF YSCVLLIMCI SVDRYIAIVQ 
       160        170        180        190        200
AMKAQVWRQK RLLYSKMVCI TIWVMAAVLC TPEILYSQVS GESGIATCTM 
       210        220        230        240        250
VYPKDKNAKL KSAVLILKVT LGFFLPFMVM AFCYTIIIHT LVQAKKSSKH 
       260        270        280        290        300
KALKVTITVL TVFIMSQFPY NSILVVQAVD AYAMFISNCT ISTNIDICFQ 
       310        320        330        340        350
VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE 
       360 
GSLKLSSMLL ETTSGALSL

Length:369

Mass (Da):41,913

Last modified:November 1, 1999 - v1

Checksum:ⁱ6971F76F0A24B4AE

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F8WIS0	F8WIS0_MOUSE		C-C chemokine receptor type 9 C-C chemokine receptor type 9	Ccr9	357	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ132336 mRNA Translation: CAB43480.1 AJ131357 mRNA Translation: CAB66136.2 AK019478 mRNA Translation: BAB31747.1 AK050615 mRNA Translation: BAC34344.1 AK153975 mRNA Translation: BAE32291.1 BC132166 mRNA Translation: AAI32167.1 BC132466 mRNA Translation: AAI32467.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23662.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001160097.1, NM_001166625.1 NP_034043.1, NM_009913.6
UniGeneⁱ	Mm.440604 Mm.442383

Genome annotation databases

Ensemblⁱ	ENSMUST00000163559; ENSMUSP00000131782; ENSMUSG00000029530 ENSMUST00000166236; ENSMUSP00000127024; ENSMUSG00000029530 ENSMUST00000168910; ENSMUSP00000126758; ENSMUSG00000029530 ENSMUST00000180093; ENSMUSP00000137144; ENSMUSG00000029530
GeneIDⁱ	12769
KEGGⁱ	mmu:12769
UCSC genome browser More...UCSCⁱ	uc009sgl.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9WUT7	C-C chemokine receptor type 9		MOUSE		357	UniRef100_Q9WUT7

Protein	Similar proteins		Species	Score	Length	Source
Q9WUT7	C-C chemokine receptor type 9		MOUSE		357	UniRef90_Q9WUT7
Uncharacterized protein		NEOLE		331
UPI000A31352C		MUSPA		369
UPI000A314D1A		MUSCR		369

Protein	Similar proteins		Species	Score	Length	Source
Q9WUT7	C-C chemokine receptor type 9	)	HUMAN		369	UniRef50_P51686
C-C motif chemokine receptor 9		PANTR		369
C-C motif chemokine receptor 9		NOMLE		369
Uncharacterized protein		COLAP		370
C-C motif chemokine receptor 9		SAIBB		369
+119

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ132336 mRNA Translation: CAB43480.1 AJ131357 mRNA Translation: CAB66136.2 AK019478 mRNA Translation: BAB31747.1 AK050615 mRNA Translation: BAC34344.1 AK153975 mRNA Translation: BAE32291.1 BC132166 mRNA Translation: AAI32167.1 BC132466 mRNA Translation: AAI32467.1
CCDSⁱ	CCDS23662.1
RefSeqⁱ	NP_001160097.1, NM_001166625.1 NP_034043.1, NM_009913.6
UniGeneⁱ	Mm.440604 Mm.442383

3D structure databases

ProteinModelPortalⁱ	Q9WUT7
SMRⁱ	Q9WUT7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198769, 1 interactor
DIPⁱ	DIP-5886N
STRINGⁱ	10090.ENSMUSP00000126758

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q9WUT7
PhosphoSitePlusⁱ	Q9WUT7

Proteomic databases

PaxDbⁱ	Q9WUT7
PRIDEⁱ	Q9WUT7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000163559; ENSMUSP00000131782; ENSMUSG00000029530 ENSMUST00000166236; ENSMUSP00000127024; ENSMUSG00000029530 ENSMUST00000168910; ENSMUSP00000126758; ENSMUSG00000029530 ENSMUST00000180093; ENSMUSP00000137144; ENSMUSG00000029530
GeneIDⁱ	12769
KEGGⁱ	mmu:12769
UCSCⁱ	uc009sgl.2 mouse

Organism-specific databases

CTDⁱ	10803
MGIⁱ	MGI:1341902 Ccr9

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00930000150843
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG106917
InParanoidⁱ	Q9WUT7
KOⁱ	K04184
OrthoDBⁱ	EOG091G093O
PhylomeDBⁱ	Q9WUT7
TreeFamⁱ	TF330966

Enzyme and pathway databases

Reactomeⁱ	R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSⁱ	Ccr9 mouse
Protein Ontology More...PROⁱ	PR:Q9WUT7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029530 Expressed in 138 organ(s), highest expression level in thymus
CleanExⁱ	MM_CCR9
ExpressionAtlasⁱ	Q9WUT7 baseline and differential
Genevisibleⁱ	Q9WUT7 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR004069 Chemokine_CCR9 IPR000355 Chemokine_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00657 CCCHEMOKINER PR01531 CHEMOKINER9 PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCR9_MOUSE
Accessionⁱ	Q9WUT7Primary (citable) accession number: Q9WUT7 Secondary accession number(s): A2RSM5, Q543I4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniParc

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UniRef

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Supporting data

UniProtKB - Q9WUT7 (CCR9_MOUSE)

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C-C chemokine receptor type 9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ