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Protein

C-C chemokine receptor type 9

Gene

Ccr9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

  • C-C chemokine binding Source: GO_Central
  • C-C chemokine receptor activity Source: MGI
  • chemokine binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 9
Short name:
C-C CKR-9
Short name:
CC-CKR-9
Short name:
CCR-9
Alternative name(s):
Chemokine C-C receptor 10
CD_antigen: CDw199
Gene namesi
Name:Ccr9
Synonyms:Cmkbr10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1341902 Ccr9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularBy similarityAdd BLAST48
Transmembranei49 – 74Helical; Name=1By similarityAdd BLAST26
Topological domaini75 – 85CytoplasmicBy similarityAdd BLAST11
Transmembranei86 – 109Helical; Name=2By similarityAdd BLAST24
Topological domaini110 – 120ExtracellularBy similarityAdd BLAST11
Transmembranei121 – 150Helical; Name=3By similarityAdd BLAST30
Topological domaini151 – 159CytoplasmicBy similarity9
Transmembranei160 – 185Helical; Name=4By similarityAdd BLAST26
Topological domaini186 – 208ExtracellularBy similarityAdd BLAST23
Transmembranei209 – 243Helical; Name=5By similarityAdd BLAST35
Topological domaini244 – 248CytoplasmicBy similarity5
Transmembranei249 – 283Helical; Name=6By similarityAdd BLAST35
Topological domaini284 – 290ExtracellularBy similarity7
Transmembranei291 – 321Helical; Name=7By similarityAdd BLAST31
Topological domaini322 – 369CytoplasmicBy similarityAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692921 – 369C-C chemokine receptor type 9Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi38 ↔ 289By similarity
Disulfide bondi119 ↔ 198PROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WUT7
PRIDEiQ9WUT7

PTM databases

iPTMnetiQ9WUT7
PhosphoSitePlusiQ9WUT7

Expressioni

Tissue specificityi

Highly expressed in the thymus and low in lymph nodes and spleen.

Gene expression databases

BgeeiENSMUSG00000029530 Expressed in 138 organ(s), highest expression level in thymus
CleanExiMM_CCR9
ExpressionAtlasiQ9WUT7 baseline and differential
GenevisibleiQ9WUT7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198769, 1 interactor
DIPiDIP-5886N
STRINGi10090.ENSMUSP00000126758

Structurei

3D structure databases

ProteinModelPortaliQ9WUT7
SMRiQ9WUT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150843
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiQ9WUT7
KOiK04184
OrthoDBiEOG091G093O
PhylomeDBiQ9WUT7
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR004069 Chemokine_CCR9
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01531 CHEMOKINER9
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WUT7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPTELTSLI PGMFDDFSYD STASTDDYMN LNFSSFFCKK NNVRQFASHF
60 70 80 90 100
LPPLYWLVFI VGTLGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLAT
110 120 130 140 150
LPFWAIAAAG QWMFQTFMCK VVNSMYKMNF YSCVLLIMCI SVDRYIAIVQ
160 170 180 190 200
AMKAQVWRQK RLLYSKMVCI TIWVMAAVLC TPEILYSQVS GESGIATCTM
210 220 230 240 250
VYPKDKNAKL KSAVLILKVT LGFFLPFMVM AFCYTIIIHT LVQAKKSSKH
260 270 280 290 300
KALKVTITVL TVFIMSQFPY NSILVVQAVD AYAMFISNCT ISTNIDICFQ
310 320 330 340 350
VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE
360
GSLKLSSMLL ETTSGALSL
Length:369
Mass (Da):41,913
Last modified:November 1, 1999 - v1
Checksum:i6971F76F0A24B4AE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WIS0F8WIS0_MOUSE
C-C chemokine receptor type 9
Ccr9
357Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132336 mRNA Translation: CAB43480.1
AJ131357 mRNA Translation: CAB66136.2
AK019478 mRNA Translation: BAB31747.1
AK050615 mRNA Translation: BAC34344.1
AK153975 mRNA Translation: BAE32291.1
BC132166 mRNA Translation: AAI32167.1
BC132466 mRNA Translation: AAI32467.1
CCDSiCCDS23662.1
RefSeqiNP_001160097.1, NM_001166625.1
NP_034043.1, NM_009913.6
UniGeneiMm.440604
Mm.442383

Genome annotation databases

EnsembliENSMUST00000163559; ENSMUSP00000131782; ENSMUSG00000029530
ENSMUST00000166236; ENSMUSP00000127024; ENSMUSG00000029530
ENSMUST00000168910; ENSMUSP00000126758; ENSMUSG00000029530
ENSMUST00000180093; ENSMUSP00000137144; ENSMUSG00000029530
GeneIDi12769
KEGGimmu:12769
UCSCiuc009sgl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132336 mRNA Translation: CAB43480.1
AJ131357 mRNA Translation: CAB66136.2
AK019478 mRNA Translation: BAB31747.1
AK050615 mRNA Translation: BAC34344.1
AK153975 mRNA Translation: BAE32291.1
BC132166 mRNA Translation: AAI32167.1
BC132466 mRNA Translation: AAI32467.1
CCDSiCCDS23662.1
RefSeqiNP_001160097.1, NM_001166625.1
NP_034043.1, NM_009913.6
UniGeneiMm.440604
Mm.442383

3D structure databases

ProteinModelPortaliQ9WUT7
SMRiQ9WUT7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198769, 1 interactor
DIPiDIP-5886N
STRINGi10090.ENSMUSP00000126758

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9WUT7
PhosphoSitePlusiQ9WUT7

Proteomic databases

PaxDbiQ9WUT7
PRIDEiQ9WUT7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163559; ENSMUSP00000131782; ENSMUSG00000029530
ENSMUST00000166236; ENSMUSP00000127024; ENSMUSG00000029530
ENSMUST00000168910; ENSMUSP00000126758; ENSMUSG00000029530
ENSMUST00000180093; ENSMUSP00000137144; ENSMUSG00000029530
GeneIDi12769
KEGGimmu:12769
UCSCiuc009sgl.2 mouse

Organism-specific databases

CTDi10803
MGIiMGI:1341902 Ccr9

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150843
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiQ9WUT7
KOiK04184
OrthoDBiEOG091G093O
PhylomeDBiQ9WUT7
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSiCcr9 mouse
PROiPR:Q9WUT7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029530 Expressed in 138 organ(s), highest expression level in thymus
CleanExiMM_CCR9
ExpressionAtlasiQ9WUT7 baseline and differential
GenevisibleiQ9WUT7 MM

Family and domain databases

InterProiView protein in InterPro
IPR004069 Chemokine_CCR9
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01531 CHEMOKINER9
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCR9_MOUSE
AccessioniPrimary (citable) accession number: Q9WUT7
Secondary accession number(s): A2RSM5, Q543I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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