Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gap junction alpha-10 protein

Gene

Gja10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning.4 Publications

GO - Molecular functioni

  • gap junction channel activity Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-112303 Electric Transmission Across Gap Junctions
R-MMU-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-10 protein
Alternative name(s):
Connexin-57
Short name:
Cx57
Gene namesi
Name:Gja10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1339969 Gja10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 76ExtracellularSequence analysisAdd BLAST39
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 165CytoplasmicSequence analysisAdd BLAST68
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 209ExtracellularSequence analysisAdd BLAST23
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 505CytoplasmicSequence analysisAdd BLAST275

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are fertile and show no obvious anatomical or behavioral abnormalities. In horizontal cells of the retina tracer coupling is abolished but the spatial tuning of ganglion cells is unchanged.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578411 – 505Gap junction alpha-10 proteinAdd BLAST505

Proteomic databases

PaxDbiQ9WUS4
PRIDEiQ9WUS4

Expressioni

Tissue specificityi

Low levels were detected in skin, heart, kidney, testis, ovary, intestine. Expression not detected in brain, sciatic nerve or liver. According to PubMed:15147297 expression is detected only in horizontal cells in the inner nuclear layer of the retina and not in other neurons of the central nervous system or tissues. Detected in the outer plexiform layer of the retina (at protein level).3 Publications

Developmental stagei

Expressed in the retina from E16.5 to P1, in the thymus from E18.5 to P1, and in kidney from E16.5 to E18.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000051056 Expressed in 3 organ(s), highest expression level in retina
CleanExiMM_GJA10
GenevisibleiQ9WUS4 MM

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061742

Structurei

3D structure databases

ProteinModelPortaliQ9WUS4
SMRiQ9WUS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGQJ Eukaryota
ENOG4110KSA LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231126
HOVERGENiHBG009576
InParanoidiQ9WUS4
KOiK07631
OMAiGCLLRTY
OrthoDBiEOG091G06LA
PhylomeDBiQ9WUS4
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9WUS4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDWNLLGGI LEEVHSHSTI VGKIWLTILF IFRMLVLGVA AEDVWDDEQS
60 70 80 90 100
AFACNTQQPG CNNICYDDAF PISLIRFWVL QIIFVSSPSL VYMGHALYRL
110 120 130 140 150
RDFEKQRQKK KLYLRAQMEN PELDLEEQQR VDKELRRLEE QKRIHKVPLK
160 170 180 190 200
GCLLRTYVLH ILTRSVLEVG FMIGQYILYG FQMHPIYKCT QAPCPNSVDC
210 220 230 240 250
FVSRPTEKTI FMLFMHSIAA ISLLLNILEI FHLGIRKIMR ALDGKSSSGN
260 270 280 290 300
TENETGPPFH STNYSGTQQC MICSSLPERI SLLQANNKQQ VIRVNIPRSK
310 320 330 340 350
SMWQIPHPRQ LEVDVSCGKR DWAEKIESCA QLHVHSPCPH DRSARIQHPG
360 370 380 390 400
QQPCHSVFGP KNAMSQSWFG TMTASQHRPS SALETWERSQ GPEASGRSLT
410 420 430 440 450
DRQSHFQGSD GSARESGVWT DRLGPGSRKA SFLSRLMSEK GQRHSDSGSS
460 470 480 490 500
RSLNSSCLDF SHGENSPSPL PSATGHRASM VSKSSHVDSP PHSSFIIHET

YVYVY
Length:505
Mass (Da):57,127
Last modified:January 15, 2008 - v2
Checksum:iF7FAFBA21EDE2A7B
GO
Isoform 2 (identifier: Q9WUS4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     481-505: VSKSSHVDSPPHSSFIIHETYVYVY → NMLLELSSIMKK

Note: No experimental confirmation available.
Show »
Length:492
Mass (Da):55,655
Checksum:i7E29240C66717170
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143R → K in CAB40358 (PubMed:10329667).Curated1
Sequence conflicti272I → V in CAB40358 (PubMed:10329667).Curated1
Sequence conflicti330A → T in CAB40358 (PubMed:10329667).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035809481 – 505VSKSS…YVYVY → NMLLELSSIMKK in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010741 Genomic DNA Translation: CAB40358.1
AL831746 Genomic DNA Translation: CAM26624.1
CCDSiCCDS18015.1 [Q9WUS4-1]
RefSeqiNP_034419.2, NM_010289.2 [Q9WUS4-1]
UniGeneiMm.377084

Genome annotation databases

EnsembliENSMUST00000056517; ENSMUSP00000061742; ENSMUSG00000051056 [Q9WUS4-1]
ENSMUST00000219644; ENSMUSP00000151323; ENSMUSG00000051056 [Q9WUS4-2]
GeneIDi14610
KEGGimmu:14610
UCSCiuc008sev.1 mouse [Q9WUS4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010741 Genomic DNA Translation: CAB40358.1
AL831746 Genomic DNA Translation: CAM26624.1
CCDSiCCDS18015.1 [Q9WUS4-1]
RefSeqiNP_034419.2, NM_010289.2 [Q9WUS4-1]
UniGeneiMm.377084

3D structure databases

ProteinModelPortaliQ9WUS4
SMRiQ9WUS4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061742

Proteomic databases

PaxDbiQ9WUS4
PRIDEiQ9WUS4

Protocols and materials databases

DNASUi14610
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056517; ENSMUSP00000061742; ENSMUSG00000051056 [Q9WUS4-1]
ENSMUST00000219644; ENSMUSP00000151323; ENSMUSG00000051056 [Q9WUS4-2]
GeneIDi14610
KEGGimmu:14610
UCSCiuc008sev.1 mouse [Q9WUS4-1]

Organism-specific databases

CTDi84694
MGIiMGI:1339969 Gja10

Phylogenomic databases

eggNOGiENOG410IGQJ Eukaryota
ENOG4110KSA LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231126
HOVERGENiHBG009576
InParanoidiQ9WUS4
KOiK07631
OMAiGCLLRTY
OrthoDBiEOG091G06LA
PhylomeDBiQ9WUS4
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-MMU-112303 Electric Transmission Across Gap Junctions
R-MMU-190861 Gap junction assembly

Miscellaneous databases

PROiPR:Q9WUS4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051056 Expressed in 3 organ(s), highest expression level in retina
CleanExiMM_GJA10
GenevisibleiQ9WUS4 MM

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXA10_MOUSE
AccessioniPrimary (citable) accession number: Q9WUS4
Secondary accession number(s): A2ANV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 15, 2008
Last modified: September 12, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again