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Protein

Oligodendrocyte transcription factor 1

Gene

Olig1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 1
Short name:
Oligo1
Alternative name(s):
Olg-1 bHLH protein
Gene namesi
Name:Olig1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621129 Olig1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274131 – 261Oligodendrocyte transcription factor 1Add BLAST261

Proteomic databases

PaxDbiQ9WUQ3
PRIDEiQ9WUQ3

Expressioni

Tissue specificityi

Expressed specifically in the brain, including the corpus callosum, hippocampal and cerebral white matter. Also detected in cells scattered in gray matter, most probably in oligodendrocytes.1 Publication

Developmental stagei

Expressed in oligodendrocytes of the postnatal optical nerve up to day 30, then the number of expressing cells decreases.1 Publication

Inductioni

By SHH.1 Publication

Gene expression databases

GenevisibleiQ9WUQ3 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002827

Structurei

3D structure databases

ProteinModelPortaliQ9WUQ3
SMRiQ9WUQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 154bHLHPROSITE-ProRule annotationAdd BLAST60

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
HOGENOMiHOG000015810
HOVERGENiHBG053369
InParanoidiQ9WUQ3
KOiK09085
OrthoDBiEOG091G0IHI
PhylomeDBiQ9WUQ3
TreeFamiTF322733

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032657 Olig1
PANTHERiPTHR19290:SF7 PTHR19290:SF7, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WUQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYYAVSQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSTS
60 70 80 90 100
SSSTASLLPK PAREKPEAPL AEPRGPAPES GGARADAKEE QQQQQLRRKI
110 120 130 140 150
NSRERKRMQD LNLAMDALRE VILPYSAAHC QGAPGRKLSK IATLLLARNY
160 170 180 190 200
ILLLGSSLQE LRRALGDGAG PAAPRLLLAG LPLLAAAPGS VLLAPGAVGP
210 220 230 240 250
PETLRPTKYL SLALDEPPCG QFALPAGGAG SPGLCSCAVC KFPHLVPAGL
260
GLAAVQAQFS K
Length:261
Mass (Da):27,239
Last modified:August 30, 2002 - v2
Checksum:iC0CE520275550322
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UHA2A0A0H2UHA2_RAT
Oligodendrocyte transcription facto...
Olig1
245Annotation score:

Sequence cautioni

The sequence AAD34029 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151367 mRNA Translation: AAD34029.1 Different initiation.
RefSeqiNP_068538.2, NM_021770.4
UniGeneiRn.45339

Genome annotation databases

GeneIDi60394
KEGGirno:60394
UCSCiRGD:621129 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151367 mRNA Translation: AAD34029.1 Different initiation.
RefSeqiNP_068538.2, NM_021770.4
UniGeneiRn.45339

3D structure databases

ProteinModelPortaliQ9WUQ3
SMRiQ9WUQ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002827

Proteomic databases

PaxDbiQ9WUQ3
PRIDEiQ9WUQ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi60394
KEGGirno:60394
UCSCiRGD:621129 rat

Organism-specific databases

CTDi116448
RGDi621129 Olig1

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
HOGENOMiHOG000015810
HOVERGENiHBG053369
InParanoidiQ9WUQ3
KOiK09085
OrthoDBiEOG091G0IHI
PhylomeDBiQ9WUQ3
TreeFamiTF322733

Miscellaneous databases

PROiPR:Q9WUQ3

Gene expression databases

GenevisibleiQ9WUQ3 RN

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032657 Olig1
PANTHERiPTHR19290:SF7 PTHR19290:SF7, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOLIG1_RAT
AccessioniPrimary (citable) accession number: Q9WUQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: November 7, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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