Olig1

Functionⁱ

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).By similarity

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

neuron fate commitment Source: InterPro
oligodendrocyte differentiation Source: InterPro
regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Oligodendrocyte transcription factor 1 Short name: Oligo1 Alternative name(s): Olg-1 bHLH protein
Gene namesⁱ	Name:Olig1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	621129 Olig1

RGDⁱ

621129 Olig1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127413	1 – 261	Oligodendrocyte transcription factor 1Add BLAST		261

Proteomic databases

PaxDbⁱ	Q9WUQ3
PRIDEⁱ	Q9WUQ3

Expressionⁱ

Tissue specificityⁱ

Expressed specifically in the brain, including the corpus callosum, hippocampal and cerebral white matter. Also detected in cells scattered in gray matter, most probably in oligodendrocytes.1 Publication

Developmental stageⁱ

Expressed in oligodendrocytes of the postnatal optical nerve up to day 30, then the number of expressing cells decreases.1 Publication

Inductionⁱ

By SHH.1 Publication

Gene expression databases

Genevisibleⁱ	Q9WUQ3 RN

Genevisibleⁱ

Q9WUQ3 RN

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000002827

STRINGⁱ

10116.ENSRNOP00000002827

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9WUQ3
SMRⁱ	Q9WUQ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	95 – 154	bHLHPROSITE-ProRule annotationAdd BLAST		60

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG4111U26 LUCA
HOGENOMⁱ	HOG000015810
HOVERGENⁱ	HBG053369
InParanoidⁱ	Q9WUQ3
KEGG Orthology (KO) More...KOⁱ	K09085
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IHI
PhylomeDBⁱ	Q9WUQ3
TreeFamⁱ	TF322733

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032657 Olig1
PANTHERⁱ	PTHR19290:SF7 PTHR19290:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9WUQ3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYYAVSQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSTS 
        60         70         80         90        100
SSSTASLLPK PAREKPEAPL AEPRGPAPES GGARADAKEE QQQQQLRRKI 
       110        120        130        140        150
NSRERKRMQD LNLAMDALRE VILPYSAAHC QGAPGRKLSK IATLLLARNY 
       160        170        180        190        200
ILLLGSSLQE LRRALGDGAG PAAPRLLLAG LPLLAAAPGS VLLAPGAVGP 
       210        220        230        240        250
PETLRPTKYL SLALDEPPCG QFALPAGGAG SPGLCSCAVC KFPHLVPAGL 
       260 
GLAAVQAQFS K

Length:261

Mass (Da):27,239

Last modified:August 30, 2002 - v2

Checksum:ⁱC0CE520275550322

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0H2UHA2	A0A0H2UHA2_RAT		Oligodendrocyte transcription facto... Oligodendrocyte transcription factor 1	Olig1	245	Annotation score:

Sequence cautionⁱ

The sequence AAD34029 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151367 mRNA Translation: AAD34029.1 Different initiation.
NCBI Reference Sequences More...RefSeqⁱ	NP_068538.2, NM_021770.4
UniGeneⁱ	Rn.45339

Genome annotation databases

GeneIDⁱ	60394
KEGGⁱ	rno:60394
UCSC genome browser More...UCSCⁱ	RGD:621129 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9WUQ3	Oligodendrocyte transcription factor 1		RAT		245	UniRef100_Q9WUQ3

Protein	Similar proteins		Species	Score	Length	Source
Q9WUQ3	Oligodendrocyte transcription factor 1		HUMAN		271	UniRef90_Q8TAK6
Oligodendrocyte transcription factor 1		MOUSE		260
OLIG1 isoform 2 (Fragment)		PONAB		31
OLIG1 isoform 2 (Fragment)		PANTR		31
oligodendrocyte transcription factor 1		NEOSC		274
+58

Protein	Similar proteins		Species	Score	Length	Source
Q9WUQ3	Oligodendrocyte transcription factor 1		HUMAN		271	UniRef50_Q8TAK6
Oligodendrocyte transcription factor 1		MOUSE		260
OLIG1 isoform 2 (Fragment)		PONAB		31
OLIG1 isoform 2 (Fragment)		PANTR		31
oligodendrocyte transcription factor 1		NEOSC		274
+70

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151367 mRNA Translation: AAD34029.1 Different initiation.
RefSeqⁱ	NP_068538.2, NM_021770.4
UniGeneⁱ	Rn.45339

3D structure databases

ProteinModelPortalⁱ	Q9WUQ3
SMRⁱ	Q9WUQ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000002827

STRINGⁱ

10116.ENSRNOP00000002827

Proteomic databases

PaxDbⁱ	Q9WUQ3
PRIDEⁱ	Q9WUQ3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	60394
KEGGⁱ	rno:60394
UCSCⁱ	RGD:621129 rat

Organism-specific databases

CTDⁱ	116448
RGDⁱ	621129 Olig1

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG4111U26 LUCA
HOGENOMⁱ	HOG000015810
HOVERGENⁱ	HBG053369
InParanoidⁱ	Q9WUQ3
KOⁱ	K09085
OrthoDBⁱ	EOG091G0IHI
PhylomeDBⁱ	Q9WUQ3
TreeFamⁱ	TF322733

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9WUQ3

PROⁱ

PR:Q9WUQ3

Gene expression databases

Genevisibleⁱ	Q9WUQ3 RN

Genevisibleⁱ

Q9WUQ3 RN

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032657 Olig1
PANTHERⁱ	PTHR19290:SF7 PTHR19290:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OLIG1_RAT
Accessionⁱ	Q9WUQ3Primary (citable) accession number: Q9WUQ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
	Last sequence update:	August 30, 2002
	Last modified:	November 7, 2018
	This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9WUQ3 (OLIG1_RAT)

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Oligodendrocyte transcription factor 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ