The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q9WUQ3 (OLIG1_RAT)
Protein
Oligodendrocyte transcription factor 1
Gene
Olig1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).
By similarityGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- neuron differentiation Source: GO_Central
- neuron fate commitment Source: RGD
- oligodendrocyte development Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Oligodendrocyte transcription factor 1Short name: Oligo1 Alternative name(s): Olg-1 bHLH protein |
Gene namesi | Name:Olig1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621129, Olig1 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127413 | 1 – 261 | Oligodendrocyte transcription factor 1Add BLAST | 261 |
Proteomic databases
jPOSTi | Q9WUQ3 |
PaxDbi | Q9WUQ3 |
PRIDEi | Q9WUQ3 |
Expressioni
Tissue specificityi
Expressed specifically in the brain, including the corpus callosum, hippocampal and cerebral white matter. Also detected in cells scattered in gray matter, most probably in oligodendrocytes.1 Publication
Developmental stagei
Expressed in oligodendrocytes of the postnatal optical nerve up to day 30, then the number of expressing cells decreases.1 Publication
Inductioni
By SHH.1 Publication
Gene expression databases
Genevisiblei | Q9WUQ3, RN |
Interactioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000002827 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 95 – 154 | bHLHPROSITE-ProRule annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 105 | DisorderedSequence analysisAdd BLAST | 65 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 41 – 58 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 83 – 105 | Basic and acidic residuesSequence analysisAdd BLAST | 23 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
HOGENOMi | CLU_060337_0_0_1 |
InParanoidi | Q9WUQ3 |
OrthoDBi | 1205889at2759 |
PhylomeDBi | Q9WUQ3 |
TreeFami | TF322733 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032657, Olig1 |
PANTHERi | PTHR19290:SF7, PTHR19290:SF7, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9WUQ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYYAVSQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSTS
60 70 80 90 100
SSSTASLLPK PAREKPEAPL AEPRGPAPES GGARADAKEE QQQQQLRRKI
110 120 130 140 150
NSRERKRMQD LNLAMDALRE VILPYSAAHC QGAPGRKLSK IATLLLARNY
160 170 180 190 200
ILLLGSSLQE LRRALGDGAG PAAPRLLLAG LPLLAAAPGS VLLAPGAVGP
210 220 230 240 250
PETLRPTKYL SLALDEPPCG QFALPAGGAG SPGLCSCAVC KFPHLVPAGL
260
GLAAVQAQFS K
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0H2UHA2 | A0A0H2UHA2_RAT | Oligodendrocyte transcription facto... | Olig1 | 245 | Annotation score: |
Sequence cautioni
The sequence AAD34029 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151367 mRNA Translation: AAD34029.1 Different initiation. |
RefSeqi | NP_068538.2, NM_021770.4 |
Genome annotation databases
Ensembli | ENSRNOT00000002827; ENSRNOP00000002827; ENSRNOG00000028648 |
GeneIDi | 60394 |
KEGGi | rno:60394 |
UCSCi | RGD:621129, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151367 mRNA Translation: AAD34029.1 Different initiation. |
RefSeqi | NP_068538.2, NM_021770.4 |
3D structure databases
AlphaFoldDBi | Q9WUQ3 |
SMRi | Q9WUQ3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000002827 |
Proteomic databases
jPOSTi | Q9WUQ3 |
PaxDbi | Q9WUQ3 |
PRIDEi | Q9WUQ3 |
Protocols and materials databases
ABCDi | Q9WUQ3, 1 sequenced antibody |
Genome annotation databases
Ensembli | ENSRNOT00000002827; ENSRNOP00000002827; ENSRNOG00000028648 |
GeneIDi | 60394 |
KEGGi | rno:60394 |
UCSCi | RGD:621129, rat |
Organism-specific databases
CTDi | 116448 |
RGDi | 621129, Olig1 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
HOGENOMi | CLU_060337_0_0_1 |
InParanoidi | Q9WUQ3 |
OrthoDBi | 1205889at2759 |
PhylomeDBi | Q9WUQ3 |
TreeFami | TF322733 |
Miscellaneous databases
PROi | PR:Q9WUQ3 |
Gene expression databases
Genevisiblei | Q9WUQ3, RN |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032657, Olig1 |
PANTHERi | PTHR19290:SF7, PTHR19290:SF7, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OLIG1_RAT | |
Accessioni | Q9WUQ3Primary (citable) accession number: Q9WUQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2002 |
Last sequence update: | August 30, 2002 | |
Last modified: | May 25, 2022 | |
This is version 121 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |