Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor LBX2

Gene

Lbx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative transcription factor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi84 – 143HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor LBX2
Alternative name(s):
Ladybird homeobox protein homolog 2
Gene namesi
Name:Lbx2
Synonyms:Lbx2h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1342288 Lbx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are healthy and fertile and do not display any phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113291 – 195Transcription factor LBX2Add BLAST195

Proteomic databases

PaxDbiQ9WUN8
PRIDEiQ9WUN8

Expressioni

Tissue specificityi

Expressed in the developing urogenital system, eye and brain.1 Publication

Developmental stagei

First detected at E10.5 in the gonadal component of the urogenital ridge. Expression dramatically increases by E11.5 in the urogenital ridges and in the cranial surface ectoderm. At this time, it is also expressed in the trigeminal ganglion and nodose ganglion. At later stages, it is expressed in the brain and organs derived from the urogenital ridge, including the gonadal tubercle, kidneys, and adrenal glands. From E14.5 to birth, expression is evident in the developing retinal neuroepithelium and the vibrissa.2 Publications

Inductioni

By PAX3 which regulates its expression.1 Publication

Gene expression databases

BgeeiENSMUSG00000034968
CleanExiMM_LBX2
GenevisibleiQ9WUN8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047134

Structurei

3D structure databases

ProteinModelPortaliQ9WUN8
SMRiQ9WUN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000007247
HOVERGENiHBG006244
InParanoidiQ9WUN8
KOiK09353
OMAiDILAPRM
OrthoDBiEOG091G09CY
TreeFamiTF325047

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WUN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSVHQRRTP FSIADILGPS MVPEAPSAPQ LPEAGPDPAS PLCALEELAS
60 70 80 90 100
KTFLGHSPRA TPQPSEGRAA PEAPPGPGAG VRRRRKSRTA FTAQQVLELE
110 120 130 140 150
RRFVFQKYLA PSERDGLAAR LGLANAQVVT WFQNRRAKLK RDVEEMRADV
160 170 180 190
ASLCGLSPGV LCYPALPDST SSPDPGPSGP DSEPNLSDEE IQVDD
Length:195
Mass (Da):20,917
Last modified:November 1, 1999 - v1
Checksum:iE106CE108933DE45
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173P → S in AAI09348 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146150 mRNA Translation: AAD31905.1
AK002897 mRNA Translation: BAB22441.1
BC109347 mRNA Translation: AAI09348.1
CCDSiCCDS20271.1
RefSeqiNP_034822.1, NM_010692.3
UniGeneiMm.20359

Genome annotation databases

EnsembliENSMUST00000041265; ENSMUSP00000047134; ENSMUSG00000034968
GeneIDi16815
KEGGimmu:16815
UCSCiuc009cmi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLBX2_MOUSE
AccessioniPrimary (citable) accession number: Q9WUN8
Secondary accession number(s): Q32M12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1999
Last modified: February 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health