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Protein

Coronin-1C

Gene

Coro1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (PubMed:27178841). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (PubMed:27178841). Required for normal distribution of mitochondria within cells (PubMed:27178841).3 Publications

GO - Molecular functioni

  • actin filament binding Source: MGI
  • Rac GTPase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1C
Alternative name(s):
Coronin-31 Publication
Gene namesi
Name:Coro1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1345964 Coro1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype (PubMed:27178841). Fibroblasts from mutant mice display a disordered actin cytoskeleton with a reduced width of the actin stress fibers. Likewise, these cells have several microtubule-organizing centers (MTOCs) and a disordered microbutule network (PubMed:27178841).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi28R → D: Decreased actin-binding. Loss of actin binding; when associated with 418-E-E-419 and 427-E-E-428. 1 Publication1
Mutagenesisi418 – 419KK → EE: Decreased actin-binding. Loss of actin binding; when associated with D-28 and 427-E-E-428. 1 Publication2
Mutagenesisi427 – 428KK → EE: Decreased actin-binding. Loss of actin binding; when associated with D-28 and 418-E-E-419. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509271 – 474Coronin-1CAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei446N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9WUM4
MaxQBiQ9WUM4
PaxDbiQ9WUM4
PeptideAtlasiQ9WUM4
PRIDEiQ9WUM4

PTM databases

iPTMnetiQ9WUM4
PhosphoSitePlusiQ9WUM4
SwissPalmiQ9WUM4

Expressioni

Tissue specificityi

Detected in skeletal muscle (at protein level) (PubMed:19651142). Detected in fibroblasts (at protein level) (PubMed:27178841). Ubiquitous (PubMed:9778037).3 Publications

Gene expression databases

BgeeiENSMUSG00000004530 Expressed in 283 organ(s), highest expression level in ileum
CleanExiMM_CORO1C
ExpressionAtlasiQ9WUM4 baseline and differential
GenevisibleiQ9WUM4 MM

Interactioni

Subunit structurei

Homotrimer (By similarity). Binds F-actin (PubMed:22364218). Interacts with RCC2 (PubMed:25074804). Interacts preferentially with nucleotide-free and GDP-bound RAC1 (PubMed:25074804). Interacts with VIM (via head domain) (PubMed:27178841).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204714, 150 interactors
IntActiQ9WUM4, 152 interactors
MINTiQ9WUM4
STRINGi10090.ENSMUSP00000004646

Structurei

3D structure databases

ProteinModelPortaliQ9WUM4
SMRiQ9WUM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati78 – 118WD 1Add BLAST41
Repeati128 – 168WD 2Add BLAST41
Repeati172 – 202WD 3Add BLAST31
Repeati215 – 249WD 4Add BLAST35
Repeati263 – 303WD 5Add BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili435 – 474By similarityAdd BLAST40

Domaini

The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.By similarity

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiQ9WUM4
KOiK13886
OMAiENDKFEF
OrthoDBiEOG091G03H5
PhylomeDBiQ9WUM4
TreeFamiTF314280

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR027333 CORO1C
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF10 PTHR10856:SF10, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9WUM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRVVRQSKF RHVFGQAVKN DQCYDDIRVS RVTWDSSFCA VNPRFVAIII
60 70 80 90 100
EASGGGAFLV LPLHKTGRID KSYPTVCGHT GPVLDIDWCP HNDQVIASGS
110 120 130 140 150
EDCTVMVWQI PENGLTLSLT EPVVILEGHS KRVGIVAWHP TARNVLLSAG
160 170 180 190 200
CDNAIIIWNV GTGEALINLD DMHSDMIYNV SWSRNGSLIC TASKDKKVRV
210 220 230 240 250
IDPRKQEIVA EKEKAHEGAR PMRAIFLADG NVFTTGFSRM SERQLALWNP
260 270 280 290 300
KNMQEPIALH EMDTSNGVLL PFYDPDTSII YLCGKGDSSI RYFEITDESP
310 320 330 340 350
YVHYLNTFSS KEPQRGMGYM PKRGLDVNKC EIARFFKLHE RKCEPIIMTV
360 370 380 390 400
PRKSDLFQDD LYPDTAGPEA ALEAEEWFEG KNADPILISL KHGYIPGKNR
410 420 430 440 450
DLKVVKKNIL DSKPAANKKS ELSCAPKKPT DTASVQNEAK LDEILKEIKS
460 470
IKETICSQDE RISKLEQQLA KMAA
Length:474
Mass (Da):53,121
Last modified:October 11, 2004 - v2
Checksum:i4B1C41E1BB59AFCF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PX03E9PX03_MOUSE
Coronin
Coro1c
159Annotation score:
E9PZJ0E9PZJ0_MOUSE
Coronin-1C
Coro1c
66Annotation score:
E9PVJ1E9PVJ1_MOUSE
Coronin-1C
Coro1c
85Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66T → S in AAD32705 (PubMed:9778037).Curated1
Sequence conflicti422L → F in AAD32705 (PubMed:9778037).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143957 mRNA Translation: AAD32705.1
AK079327 mRNA Translation: BAC37609.1
AK082986 mRNA Translation: BAC38722.1
AK088101 mRNA Translation: BAC40144.1
AK151017 mRNA Translation: BAE30036.1
AK151749 mRNA Translation: BAE30659.1
AK167089 mRNA Translation: BAE39246.1
AK159506 mRNA Translation: BAE35139.1
CH466529 Genomic DNA Translation: EDL19932.1
BC019444 mRNA Translation: AAH19444.1
BC085498 mRNA Translation: AAH85498.1
BC099671 mRNA Translation: AAH99671.1
CCDSiCCDS19555.1
RefSeqiNP_035909.2, NM_011779.3
UniGeneiMm.260158

Genome annotation databases

EnsembliENSMUST00000004646; ENSMUSP00000004646; ENSMUSG00000004530
GeneIDi23790
KEGGimmu:23790
UCSCiuc008yyu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143957 mRNA Translation: AAD32705.1
AK079327 mRNA Translation: BAC37609.1
AK082986 mRNA Translation: BAC38722.1
AK088101 mRNA Translation: BAC40144.1
AK151017 mRNA Translation: BAE30036.1
AK151749 mRNA Translation: BAE30659.1
AK167089 mRNA Translation: BAE39246.1
AK159506 mRNA Translation: BAE35139.1
CH466529 Genomic DNA Translation: EDL19932.1
BC019444 mRNA Translation: AAH19444.1
BC085498 mRNA Translation: AAH85498.1
BC099671 mRNA Translation: AAH99671.1
CCDSiCCDS19555.1
RefSeqiNP_035909.2, NM_011779.3
UniGeneiMm.260158

3D structure databases

ProteinModelPortaliQ9WUM4
SMRiQ9WUM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204714, 150 interactors
IntActiQ9WUM4, 152 interactors
MINTiQ9WUM4
STRINGi10090.ENSMUSP00000004646

PTM databases

iPTMnetiQ9WUM4
PhosphoSitePlusiQ9WUM4
SwissPalmiQ9WUM4

Proteomic databases

EPDiQ9WUM4
MaxQBiQ9WUM4
PaxDbiQ9WUM4
PeptideAtlasiQ9WUM4
PRIDEiQ9WUM4

Protocols and materials databases

DNASUi23790
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004646; ENSMUSP00000004646; ENSMUSG00000004530
GeneIDi23790
KEGGimmu:23790
UCSCiuc008yyu.1 mouse

Organism-specific databases

CTDi23603
MGIiMGI:1345964 Coro1c

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiQ9WUM4
KOiK13886
OMAiENDKFEF
OrthoDBiEOG091G03H5
PhylomeDBiQ9WUM4
TreeFamiTF314280

Miscellaneous databases

ChiTaRSiCoro1c mouse
PROiPR:Q9WUM4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004530 Expressed in 283 organ(s), highest expression level in ileum
CleanExiMM_CORO1C
ExpressionAtlasiQ9WUM4 baseline and differential
GenevisibleiQ9WUM4 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR027333 CORO1C
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF10 PTHR10856:SF10, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOR1C_MOUSE
AccessioniPrimary (citable) accession number: Q9WUM4
Secondary accession number(s): Q499X7, Q8VCQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 11, 2004
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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