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Protein

Programmed cell death 1 ligand 2

Gene

Pdcd1lg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.3 Publications

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-389948 PD-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death 1 ligand 2
Short name:
PD-1 ligand 2
Short name:
PD-L2
Short name:
PDCD1 ligand 2
Short name:
Programmed death ligand 2
Alternative name(s):
Butyrophilin B7-DC
Short name:
B7-DC
CD_antigen: CD273
Gene namesi
Name:Pdcd1lg2
Synonyms:B7dc, Btdc, Cd273, Pdl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1930125 Pdcd1lg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 221ExtracellularSequence analysisAdd BLAST202
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 247CytoplasmicSequence analysis5

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi33D → S: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi39S → Y: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi41E → S: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi56R → S: Significantly reduces the binding to PDCD1. 1 Publication1
Mutagenesisi58S → Y: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi65D → S: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi67S → Y: Significantly reduces the binding to PDCD1. 1 Publication1
Mutagenesisi71E → S: Significantly reduces the binding to PDCD1. 1 Publication1
Mutagenesisi72R → S: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi84K → S: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi88H → A: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi101R → S: Significantly reduces the binding to PDCD1. 1 Publication1
Mutagenesisi103L → A: No effect on PDCD1 binding. 1 Publication1
Mutagenesisi105I → A: Abolishes the binding to PDCD1. 1 Publication1
Mutagenesisi111D → S: Abolishes the binding to PDCD1. Costimulates proliferation and IFNG production of T-cells. 1 Publication1
Mutagenesisi113K → S: Abolishes the binding to PDCD1. Costimulates proliferation and IFNG production of T-cells. 1 Publication1
Mutagenesisi116T → Y: No effect on PDCD1 binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001455620 – 247Programmed cell death 1 ligand 2Add BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 102PROSITE-ProRule annotation
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 192PROSITE-ProRule annotation1 Publication
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WUL5
PRIDEiQ9WUL5

PTM databases

PhosphoSitePlusiQ9WUL5

Expressioni

Tissue specificityi

Expressed in immature and mature bone marrow-derived dendritic cells and splenic dendritic cells. Highly expressed in placenta, liver and weakly expressed in heart, spleen, lymph nodes and thymus. Also expressed in some tumor cell lines of lymphoid origin.2 Publications

Gene expression databases

BgeeiENSMUSG00000016498 Expressed in 29 organ(s), highest expression level in camera-type eye
CleanExiMM_PDCD1LG2
ExpressionAtlasiQ9WUL5 baseline and differential
GenevisibleiQ9WUL5 MM

Interactioni

Subunit structurei

Interacts with PDCD1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Pdcd1Q022422EBI-15716794,EBI-5258903

Protein-protein interaction databases

BioGridi208388, 1 interactor
DIPiDIP-46166N
IntActiQ9WUL5, 1 interactor
STRINGi10090.ENSMUSP00000108195

Structurei

Secondary structure

1247
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9WUL5
SMRiQ9WUL5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WUL5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 118Ig-like V-typeAdd BLAST98
Domaini122 – 203Ig-like C2-typeAdd BLAST82

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVCK Eukaryota
ENOG4111V14 LUCA
GeneTreeiENSGT00930000150918
HOGENOMiHOG000059625
HOVERGENiHBG082112
InParanoidiQ9WUL5
KOiK06708
OMAiPANTSHT
OrthoDBiEOG091G0F5W
PhylomeDBiQ9WUL5
TreeFamiTF331083

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLLLPILNL SLQLHPVAAL FTVTAPKEVY TVDVGSSVSL ECDFDRRECT
60 70 80 90 100
ELEGIRASLQ KVENDTSLQS ERATLLEEQL PLGKALFHIP SVQVRDSGQY
110 120 130 140 150
RCLVICGAAW DYKYLTVKVK ASYMRIDTRI LEVPGTGEVQ LTCQARGYPL
160 170 180 190 200
AEVSWQNVSV PANTSHIRTP EGLYQVTSVL RLKPQPSRNF SCMFWNAHMK
210 220 230 240
ELTSAIIDPL SRMEPKVPRT WPLHVFIPAC TIALIFLAIV IIQRKRI
Length:247
Mass (Da):27,820
Last modified:November 1, 1999 - v1
Checksum:i9BFDDE14F3EC138F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142780 mRNA Translation: AAD33892.1
AK089369 mRNA Translation: BAC40858.1
CCDSiCCDS29736.1
RefSeqiNP_067371.1, NM_021396.2
UniGeneiMm.116737

Genome annotation databases

EnsembliENSMUST00000112576; ENSMUSP00000108195; ENSMUSG00000016498
GeneIDi58205
KEGGimmu:58205
UCSCiuc008hdk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142780 mRNA Translation: AAD33892.1
AK089369 mRNA Translation: BAC40858.1
CCDSiCCDS29736.1
RefSeqiNP_067371.1, NM_021396.2
UniGeneiMm.116737

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BOVX-ray1.77A20-123[»]
3BP5X-ray1.80B20-220[»]
3BP6X-ray1.60B20-220[»]
3RNKX-ray1.74B20-123[»]
3RNQX-ray1.60B20-220[»]
ProteinModelPortaliQ9WUL5
SMRiQ9WUL5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208388, 1 interactor
DIPiDIP-46166N
IntActiQ9WUL5, 1 interactor
STRINGi10090.ENSMUSP00000108195

PTM databases

PhosphoSitePlusiQ9WUL5

Proteomic databases

PaxDbiQ9WUL5
PRIDEiQ9WUL5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112576; ENSMUSP00000108195; ENSMUSG00000016498
GeneIDi58205
KEGGimmu:58205
UCSCiuc008hdk.2 mouse

Organism-specific databases

CTDi80380
MGIiMGI:1930125 Pdcd1lg2

Phylogenomic databases

eggNOGiENOG410IVCK Eukaryota
ENOG4111V14 LUCA
GeneTreeiENSGT00930000150918
HOGENOMiHOG000059625
HOVERGENiHBG082112
InParanoidiQ9WUL5
KOiK06708
OMAiPANTSHT
OrthoDBiEOG091G0F5W
PhylomeDBiQ9WUL5
TreeFamiTF331083

Enzyme and pathway databases

ReactomeiR-MMU-389948 PD-1 signaling

Miscellaneous databases

EvolutionaryTraceiQ9WUL5
PROiPR:Q9WUL5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016498 Expressed in 29 organ(s), highest expression level in camera-type eye
CleanExiMM_PDCD1LG2
ExpressionAtlasiQ9WUL5 baseline and differential
GenevisibleiQ9WUL5 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPD1L2_MOUSE
AccessioniPrimary (citable) accession number: Q9WUL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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