Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Opsin-3

Gene

Opn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in encephalic photoreception.

GO - Molecular functioni

  • G protein-coupled photoreceptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological process
LigandChromophore

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin-3
Alternative name(s):
Encephalopsin
Panopsin
Gene namesi
Name:Opn3
Synonyms:Ecpn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1338022 Opn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 75CytoplasmicSequence analysisAdd BLAST12
Transmembranei76 – 100Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini101 – 115ExtracellularSequence analysisAdd BLAST15
Transmembranei116 – 135Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini136 – 151CytoplasmicSequence analysisAdd BLAST16
Transmembranei152 – 175Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini176 – 199ExtracellularSequence analysisAdd BLAST24
Transmembranei200 – 227Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini228 – 253CytoplasmicSequence analysisAdd BLAST26
Transmembranei254 – 277Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini278 – 285ExtracellularSequence analysis8
Transmembranei286 – 310Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini311 – 400CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978141 – 400Opsin-3Add BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 186PROSITE-ProRule annotation
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei297N6-(retinylidene)lysine1
Lipidationi323S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9WUK7
PRIDEiQ9WUK7

PTM databases

PhosphoSitePlusiQ9WUK7

Expressioni

Gene expression databases

BgeeiENSMUSG00000026525 Expressed in 206 organ(s), highest expression level in brown adipose tissue
CleanExiMM_OPN3
GenevisibleiQ9WUK7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027809

Structurei

3D structure databases

ProteinModelPortaliQ9WUK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000029042
HOVERGENiHBG100337
InParanoidiQ9WUK7
KOiK04256
OMAiIMAYCYG
OrthoDBiEOG091G0ALC
PhylomeDBiQ9WUK7
TreeFamiTF324998

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WUK7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSGNRSGDQ GYWEDGAGAE GAAPAGTRSP APLFSPTAYE RLALLLGCLA
60 70 80 90 100
LLGVGGNLLV LLLYSKFPRL RTPTHLFLVN LSLGDLLVSL FGVTFTFASC
110 120 130 140 150
LRNGWVWDAV GCAWDGFSGS LFGFVSITTL TVLAYERYIR VVHARVINFS
160 170 180 190 200
WAWRAITYIW LYSLAWAGAP LLGWNRYILD IHGLGCTVDW RSKDANDSSF
210 220 230 240 250
VLFLFLGCLV VPVGIIAHCY GHILYSVRML RCVEDLQTIQ VIKMLRYEKK
260 270 280 290 300
VAKMCFLMAF VFLTCWMPYI VTRFLVVNGY GHLVTPTVSI VSYLFAKSST
310 320 330 340 350
VYNPVIYIFM NRKFRRSLLQ LLCFRLLRCQ RPAKNLPAAE SEMHIRPIVM
360 370 380 390 400
SQKDGDRPKK KVTFNSSSII FIITSDESLS VEDSDRSSAS KVDVIQVRPL
Length:400
Mass (Da):44,947
Last modified:November 1, 1999 - v1
Checksum:iAAFA81386C48BDB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140241 mRNA Translation: AAD32670.1
AF482427 Genomic DNA Translation: AAO15719.1
AK043135 mRNA Translation: BAC31471.1
AK132822 mRNA Translation: BAE21380.1
CCDSiCCDS15549.1
RefSeqiNP_034228.1, NM_010098.3
UniGeneiMm.32744

Genome annotation databases

EnsembliENSMUST00000027809; ENSMUSP00000027809; ENSMUSG00000026525
GeneIDi13603
KEGGimmu:13603
UCSCiuc007dtq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140241 mRNA Translation: AAD32670.1
AF482427 Genomic DNA Translation: AAO15719.1
AK043135 mRNA Translation: BAC31471.1
AK132822 mRNA Translation: BAE21380.1
CCDSiCCDS15549.1
RefSeqiNP_034228.1, NM_010098.3
UniGeneiMm.32744

3D structure databases

ProteinModelPortaliQ9WUK7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027809

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9WUK7

Proteomic databases

PaxDbiQ9WUK7
PRIDEiQ9WUK7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027809; ENSMUSP00000027809; ENSMUSG00000026525
GeneIDi13603
KEGGimmu:13603
UCSCiuc007dtq.2 mouse

Organism-specific databases

CTDi23596
MGIiMGI:1338022 Opn3

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000029042
HOVERGENiHBG100337
InParanoidiQ9WUK7
KOiK04256
OMAiIMAYCYG
OrthoDBiEOG091G0ALC
PhylomeDBiQ9WUK7
TreeFamiTF324998

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Miscellaneous databases

PROiPR:Q9WUK7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026525 Expressed in 206 organ(s), highest expression level in brown adipose tissue
CleanExiMM_OPN3
GenevisibleiQ9WUK7 MM

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPN3_MOUSE
AccessioniPrimary (citable) accession number: Q9WUK7
Secondary accession number(s): Q3V0X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again