Opn3

Functionⁱ

May play a role in encephalic photoreception.

GO - Molecular functionⁱ

G protein-coupled photoreceptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to light stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phototransduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-chromophore linkage Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological process
Ligand	Chromophore

Enzyme and pathway databases

Reactomeⁱ	R-MMU-418594 G alpha (i) signalling events R-MMU-419771 Opsins

Reactomeⁱ

R-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Opsin-3 Alternative name(s): Encephalopsin Panopsin
Gene namesⁱ	Name:Opn3 Synonyms:Ecpn
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1338022 Opn3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 38	ExtracellularSequence analysisAdd BLAST	38
Transmembraneⁱ	39 – 63	Helical; Name=1Sequence analysisAdd BLAST	25
Topological domainⁱ	64 – 75	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	76 – 100	Helical; Name=2Sequence analysisAdd BLAST	25
Topological domainⁱ	101 – 115	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	116 – 135	Helical; Name=3Sequence analysisAdd BLAST	20
Topological domainⁱ	136 – 151	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	152 – 175	Helical; Name=4Sequence analysisAdd BLAST	24
Topological domainⁱ	176 – 199	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	200 – 227	Helical; Name=5Sequence analysisAdd BLAST	28
Topological domainⁱ	228 – 253	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	254 – 277	Helical; Name=6Sequence analysisAdd BLAST	24
Topological domainⁱ	278 – 285	ExtracellularSequence analysis	8
Transmembraneⁱ	286 – 310	Helical; Name=7Sequence analysisAdd BLAST	25
Topological domainⁱ	311 – 400	CytoplasmicSequence analysisAdd BLAST	90

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000197814	1 – 400	Opsin-3Add BLAST		400

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	112 ↔ 186	PROSITE-ProRule annotation
Glycosylationⁱ	196	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	297	N6-(retinylidene)lysine	1
Lipidationⁱ	323	S-palmitoyl cysteineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	Q9WUK7
PRIDEⁱ	Q9WUK7

PTM databases

PhosphoSitePlusⁱ	Q9WUK7

PhosphoSitePlusⁱ

Q9WUK7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000026525 Expressed in 206 organ(s), highest expression level in brown adipose tissue
CleanExⁱ	MM_OPN3
Genevisibleⁱ	Q9WUK7 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000027809

STRINGⁱ

10090.ENSMUSP00000027809

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9WUK7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118977
HOGENOMⁱ	HOG000029042
HOVERGENⁱ	HBG100337
InParanoidⁱ	Q9WUK7
KEGG Orthology (KO) More...KOⁱ	K04256
OMAⁱ	IMAYCYG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ALC
PhylomeDBⁱ	Q9WUK7
TreeFamⁱ	TF324998

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR027430 Retinal_BS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9WUK7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYSGNRSGDQ GYWEDGAGAE GAAPAGTRSP APLFSPTAYE RLALLLGCLA 
        60         70         80         90        100
LLGVGGNLLV LLLYSKFPRL RTPTHLFLVN LSLGDLLVSL FGVTFTFASC 
       110        120        130        140        150
LRNGWVWDAV GCAWDGFSGS LFGFVSITTL TVLAYERYIR VVHARVINFS 
       160        170        180        190        200
WAWRAITYIW LYSLAWAGAP LLGWNRYILD IHGLGCTVDW RSKDANDSSF 
       210        220        230        240        250
VLFLFLGCLV VPVGIIAHCY GHILYSVRML RCVEDLQTIQ VIKMLRYEKK 
       260        270        280        290        300
VAKMCFLMAF VFLTCWMPYI VTRFLVVNGY GHLVTPTVSI VSYLFAKSST 
       310        320        330        340        350
VYNPVIYIFM NRKFRRSLLQ LLCFRLLRCQ RPAKNLPAAE SEMHIRPIVM 
       360        370        380        390        400
SQKDGDRPKK KVTFNSSSII FIITSDESLS VEDSDRSSAS KVDVIQVRPL

Length:400

Mass (Da):44,947

Last modified:November 1, 1999 - v1

Checksum:ⁱAAFA81386C48BDB5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF140241 mRNA Translation: AAD32670.1 AF482427 Genomic DNA Translation: AAO15719.1 AK043135 mRNA Translation: BAC31471.1 AK132822 mRNA Translation: BAE21380.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15549.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034228.1, NM_010098.3
UniGeneⁱ	Mm.32744

Genome annotation databases

Ensemblⁱ	ENSMUST00000027809; ENSMUSP00000027809; ENSMUSG00000026525
GeneIDⁱ	13603
KEGGⁱ	mmu:13603
UCSC genome browser More...UCSCⁱ	uc007dtq.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9WUK7	Opn3 protein		MOUSE		172	UniRef100_Q9WUK7

Protein	Similar proteins		Species	Score	Length	Source
Q9WUK7	Opn3 protein		MOUSE		172	UniRef90_Q9WUK7
Opsin 3		RAT		400
UPI0004ED1275		NANGA		401
UPI00038C1276		MICOH		400
UPI000A30D016		MUSPA		400
+5

Protein	Similar proteins		Species	Score	Length	Source
Q9WUK7	Opn3 protein		MOUSE		172	UniRef50_Q9WUK7
Opsin 3		RAT		400
Opsin 3		MUSPF		277
opsin-3		MESAU		400
Uncharacterized protein		ICTTR		402
+39

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF140241 mRNA Translation: AAD32670.1 AF482427 Genomic DNA Translation: AAO15719.1 AK043135 mRNA Translation: BAC31471.1 AK132822 mRNA Translation: BAE21380.1
CCDSⁱ	CCDS15549.1
RefSeqⁱ	NP_034228.1, NM_010098.3
UniGeneⁱ	Mm.32744

3D structure databases

ProteinModelPortalⁱ	Q9WUK7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000027809

STRINGⁱ

10090.ENSMUSP00000027809

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	Q9WUK7

PhosphoSitePlusⁱ

Q9WUK7

Proteomic databases

PaxDbⁱ	Q9WUK7
PRIDEⁱ	Q9WUK7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027809; ENSMUSP00000027809; ENSMUSG00000026525
GeneIDⁱ	13603
KEGGⁱ	mmu:13603
UCSCⁱ	uc007dtq.2 mouse

Organism-specific databases

CTDⁱ	23596
MGIⁱ	MGI:1338022 Opn3

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000118977
HOGENOMⁱ	HOG000029042
HOVERGENⁱ	HBG100337
InParanoidⁱ	Q9WUK7
KOⁱ	K04256
OMAⁱ	IMAYCYG
OrthoDBⁱ	EOG091G0ALC
PhylomeDBⁱ	Q9WUK7
TreeFamⁱ	TF324998

Enzyme and pathway databases

Reactomeⁱ	R-MMU-418594 G alpha (i) signalling events R-MMU-419771 Opsins

Reactomeⁱ

R-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9WUK7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026525 Expressed in 206 organ(s), highest expression level in brown adipose tissue
CleanExⁱ	MM_OPN3
Genevisibleⁱ	Q9WUK7 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR027430 Retinal_BS
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OPN3_MOUSE
Accessionⁱ	Q9WUK7Primary (citable) accession number: Q9WUK7 Secondary accession number(s): Q3V0X3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniParc

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UniProtKB - Q9WUK7 (OPN3_MOUSE)

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Opsin-3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ